Open Access

CD8+ T cells located in tertiary lymphoid structures are associated with improved prognosis in patients with gastric cancer

  • Authors:
    • Qing Li
    • Dachuan Zhang
    • Wenting He
    • Tongbing Chen
    • Zhantao Yan
    • Xie Gao
    • Lujun Chen
    • Xiao Zheng
    • Bin Xu
    • Binfeng Lu
    • Jingting Jiang
  • View Affiliations

  • Published online on: July 8, 2020     https://doi.org/10.3892/ol.2020.11828
  • Pages: 2655-2664
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The presence of tumor infiltrating lymphocytes (TILs) and tertiary lymphoid structures (TLSs) in tumor tissues are of great prognostic significance in several types of human cancer. The present study investigated the density of TILs and TLSs in gastric cancer (GC) tissues and their association with pathological parameters. Moreover, the clinical significance of follicular CD8+ cytotoxic T cells present within the germinal centers of the tumor‑associated TLSs was investigated. Immunohistochemistry and H&E staining were used to examine the infiltration and distribution patterns of TILs, TLSs and germinal center (gc) CD8+ TILs in tumor tissues obtained from 63 patients with GC. The number of TILs, TLSs, combination of TILs and TLSs (TILs‑TLSs) and gcCD8+ TILs were used to define tumoral immune parameters, and the prognostic value of these parameters was assessed. The analysis revealed that patients with GC with increased levels of TILs, TLSs, or gcCD8+ TILs exhibited improved overall survival. In addition, gcCD8+ TILs levels were significantly associated with patient age, histological grade and pTN stage. Increased levels of TILs‑TLSs were positively associated with nerve invasion, tumor thrombus, nodal metastasis and histological grade. Multivariate Cox regression analysis revealed that TILs‑TLSs and gcCD8+ TILs were independent prognostic factors. The data obtained in the present study demonstrated that high levels of tumoral immune parameters are important independent prognostic predictors for human GC. The results also suggested a possible role of gcCD8+ TILs in tumor immune surveillance.

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September-2020
Volume 20 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Li Q, Zhang D, He W, Chen T, Yan Z, Gao X, Chen L, Zheng X, Xu B, Lu B, Lu B, et al: CD8+ T cells located in tertiary lymphoid structures are associated with improved prognosis in patients with gastric cancer. Oncol Lett 20: 2655-2664, 2020
APA
Li, Q., Zhang, D., He, W., Chen, T., Yan, Z., Gao, X. ... Jiang, J. (2020). CD8+ T cells located in tertiary lymphoid structures are associated with improved prognosis in patients with gastric cancer. Oncology Letters, 20, 2655-2664. https://doi.org/10.3892/ol.2020.11828
MLA
Li, Q., Zhang, D., He, W., Chen, T., Yan, Z., Gao, X., Chen, L., Zheng, X., Xu, B., Lu, B., Jiang, J."CD8+ T cells located in tertiary lymphoid structures are associated with improved prognosis in patients with gastric cancer". Oncology Letters 20.3 (2020): 2655-2664.
Chicago
Li, Q., Zhang, D., He, W., Chen, T., Yan, Z., Gao, X., Chen, L., Zheng, X., Xu, B., Lu, B., Jiang, J."CD8+ T cells located in tertiary lymphoid structures are associated with improved prognosis in patients with gastric cancer". Oncology Letters 20, no. 3 (2020): 2655-2664. https://doi.org/10.3892/ol.2020.11828