Open Access

Exosomal miR‑34b inhibits proliferation and the epithelial‑mesenchymal transition by targeting Notch2 in ovarian cancer

  • Authors:
    • Shenglian Lu
    • Wuxia Liu
    • Hong Shi
    • Han Zhou
  • View Affiliations

  • Published online on: July 9, 2020     https://doi.org/10.3892/ol.2020.11837
  • Pages: 2721-2728
  • Copyright: © Lu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Exosomal microRNA (miR) can affect signaling pathways in various physiological and pathological conditions, including ovarian cancer (OC). miR‑34b, the first microRNA targeted in a human clinical trial for cancer treatment, exhibited decreased expression in several cancer types. However, the biological function of exosomal miR‑34b in OC has not been elucidated. In the present study, using reverse transcription‑quantitative PCR, it was reported that exosomal miR‑34b is downregulated in OC cells. Exosomal miR‑34b reduced cell proliferation and epithelial‑mesenchymal transition (EMT) in the OC cell line SKOV3. In addition, it was confirmed that Notch2, which is upregulated in SKOV3 cells, is a target of miR‑34b. Moreover, exosomal miR‑34b and Notch2 levels were found to be negatively correlated. The present data highlights the importance of exosomal miR‑34b‑mediated inhibition of cell proliferation and EMT, suggesting that exosomal miR‑34b has value as a diagnostic biomarker and a potential molecular target for the treatment of OC.

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September-2020
Volume 20 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Lu S, Liu W, Shi H and Zhou H: Exosomal miR‑34b inhibits proliferation and the epithelial‑mesenchymal transition by targeting Notch2 in ovarian cancer. Oncol Lett 20: 2721-2728, 2020
APA
Lu, S., Liu, W., Shi, H., & Zhou, H. (2020). Exosomal miR‑34b inhibits proliferation and the epithelial‑mesenchymal transition by targeting Notch2 in ovarian cancer. Oncology Letters, 20, 2721-2728. https://doi.org/10.3892/ol.2020.11837
MLA
Lu, S., Liu, W., Shi, H., Zhou, H."Exosomal miR‑34b inhibits proliferation and the epithelial‑mesenchymal transition by targeting Notch2 in ovarian cancer". Oncology Letters 20.3 (2020): 2721-2728.
Chicago
Lu, S., Liu, W., Shi, H., Zhou, H."Exosomal miR‑34b inhibits proliferation and the epithelial‑mesenchymal transition by targeting Notch2 in ovarian cancer". Oncology Letters 20, no. 3 (2020): 2721-2728. https://doi.org/10.3892/ol.2020.11837