Open Access

Extranodal NK/T‑cell lymphoma, nasal type without evidence of EBV infection

  • Authors:
    • Wei Wang
    • Lin Nong
    • Li Liang
    • Yalin Zheng
    • Dong Li
    • Xin Li
    • Ting Li
  • View Affiliations

  • Published online on: July 9, 2020     https://doi.org/10.3892/ol.2020.11842
  • Pages: 2665-2676
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Extranodal natural killer/T cell lymphoma‑nasal type (EN‑NK/T‑NT) is extremely rare in Western countries; however, it is the most common subtype of peripheral T cell lymphoma in China. Despite this, there are a limited number of clinicopathological research studies on Epstein‑Barr virus (EBV)‑negative EN‑NK/T‑NTs. EBV‑negative EN‑NK/T‑NT is a rare disease type, which has not been fully investigated. If other diagnostic criteria are met, such as the lesions being located predominantly in the upper aerodigestive tract, the presence of angiocentricity or angioinvasion, necrosis and expression of NK/T‑cell phenotype, EN‑NK/T‑NT may be diagnosed, even if EBV is negative. In the present study, 99 cases of EN‑NK/T‑NTs were analyzed retrospectively, among which seven cases were EBV‑negative EN‑NK/T‑NTs and selected for further investigation. In addition, the present study reviewed previously published research into EN‑NK/T‑NT, highlighting that EBV‑negative EN‑NK/T‑NT is rare and that its geographical distribution is mainly in countries in Asia, Central America and South America. Patients with EBV‑negative EN‑NK/T‑NT were all of Chinese ethnicity, with a median age of 32 years and primarily female. Furthermore, these patients shared similar clinicopathological characteristics (such as the tumor occurring mainly in the upper aerodigestive tract, the presence of vascular destruction, necrosis and cytotoxic phenotypes) to patients with EBV‑positive EN‑NK/T‑NT. Immunohistochemistry and molecular analysis results indicated that tumor cells were primarily of NK or cytotoxic T origin; however, EBV‑encoded small RNAs were not detected in any of these cases. Among the immunochemistry markers, T‑bet was statistical significantly different between EBV‑positive and ‑negative cases. Fluorescence in situ hybridization was also performed in two EBV‑negative cases, including one case with a co‑deletion of 6q21 and PR/SET domain 1 genes. There was only available follow‑up data in 3/5 patients who survived for 37‑113 months (median, 40 months). As EN‑NK/T‑NT can be diagnosed, even when EBV is negative, awareness of this subtype may prevent misdiagnosis or delayed diagnosis.

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September-2020
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Copy and paste a formatted citation
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Spandidos Publications style
Wang W, Nong L, Liang L, Zheng Y, Li D, Li X and Li T: Extranodal NK/T‑cell lymphoma, nasal type without evidence of EBV infection. Oncol Lett 20: 2665-2676, 2020
APA
Wang, W., Nong, L., Liang, L., Zheng, Y., Li, D., Li, X., & Li, T. (2020). Extranodal NK/T‑cell lymphoma, nasal type without evidence of EBV infection. Oncology Letters, 20, 2665-2676. https://doi.org/10.3892/ol.2020.11842
MLA
Wang, W., Nong, L., Liang, L., Zheng, Y., Li, D., Li, X., Li, T."Extranodal NK/T‑cell lymphoma, nasal type without evidence of EBV infection". Oncology Letters 20.3 (2020): 2665-2676.
Chicago
Wang, W., Nong, L., Liang, L., Zheng, Y., Li, D., Li, X., Li, T."Extranodal NK/T‑cell lymphoma, nasal type without evidence of EBV infection". Oncology Letters 20, no. 3 (2020): 2665-2676. https://doi.org/10.3892/ol.2020.11842