Open Access

Upregulation of COL8A1 indicates poor prognosis across human cancer types and promotes the proliferation of gastric cancer cells

  • Authors:
    • Jun Zhou
    • Yaning Song
    • Wei Gan
    • Liye Liu
    • Guibing Chen
    • Zhenyu Chen
    • Guode Luo
    • Lin Zhang
    • Guohu Zhang
    • Peihong Wang
    • Yongkuan Cao
  • View Affiliations

  • Published online on: July 21, 2020     https://doi.org/10.3892/ol.2020.11895
  • Article Number: 34
  • Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Gastric cancer (GC) was one of the most common types of the digestive system. COL8A1 was reported to be associated with cancer progression. The present study showed COL8A1 was overexpressed and correlated to shorter overall survival (OS) time across human cancer types. Specially, our results showed COL8A1 was up‑regulated in advanced stage GC compared to low stage GC samples. Higher expression of COL8A1 was significantly correlated to shorter OS time in patients with GC. Bioinformatics analysis revealed COL8A1 was involved in regulating cell proliferation and metastasis. Experimental validations of COL8A1 showed that silencing of COL8A1 could significantly suppressed cell proliferation, migration and invasion in GC. These results provided a potential target for the clinical prognosis and treatment of gastric cancer.
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October-2020
Volume 20 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhou J, Song Y, Gan W, Liu L, Chen G, Chen Z, Luo G, Zhang L, Zhang G, Wang P, Wang P, et al: Upregulation of COL8A1 indicates poor prognosis across human cancer types and promotes the proliferation of gastric cancer cells. Oncol Lett 20: 34, 2020
APA
Zhou, J., Song, Y., Gan, W., Liu, L., Chen, G., Chen, Z. ... Cao, Y. (2020). Upregulation of COL8A1 indicates poor prognosis across human cancer types and promotes the proliferation of gastric cancer cells. Oncology Letters, 20, 34. https://doi.org/10.3892/ol.2020.11895
MLA
Zhou, J., Song, Y., Gan, W., Liu, L., Chen, G., Chen, Z., Luo, G., Zhang, L., Zhang, G., Wang, P., Cao, Y."Upregulation of COL8A1 indicates poor prognosis across human cancer types and promotes the proliferation of gastric cancer cells". Oncology Letters 20.4 (2020): 34.
Chicago
Zhou, J., Song, Y., Gan, W., Liu, L., Chen, G., Chen, Z., Luo, G., Zhang, L., Zhang, G., Wang, P., Cao, Y."Upregulation of COL8A1 indicates poor prognosis across human cancer types and promotes the proliferation of gastric cancer cells". Oncology Letters 20, no. 4 (2020): 34. https://doi.org/10.3892/ol.2020.11895