Open Access

Cluster of differentiation 19 chimeric antigen receptor T‑cell therapy in pediatric acute lymphoblastic leukemia (Review)

  • Authors:
    • Zexin Fu
    • Jinlei Zhou
    • Rui Chen
    • Yihua Jin
    • Ting Ni
    • Lingbo Qian
    • Chi Xiao
  • View Affiliations

  • Published online on: July 22, 2020     https://doi.org/10.3892/ol.2020.11897
  • Article Number: 36
  • Copyright: © Fu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Chimeric antigen receptor (CAR) T cells have an unprecedented positive curative effect for hematological malignances. Most notably, cluster of differentiation 19 (CD19) CAR T‑cell therapy for pediatric acute lymphoblastic leukemia is associated with a high complete remission rate and has aroused considerable attention in the medical field. However, it also causes a series of adverse reactions and increases the risk of recurrence. The present review examines the results of CD19 CAR T‑cell therapy and lists its adverse effects. In addition, some of the mechanisms of recurrence are characterized and applicable strategies to address this challenging problem are proposed.
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October-2020
Volume 20 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Fu Z, Zhou J, Chen R, Jin Y, Ni T, Qian L and Xiao C: Cluster of differentiation 19 chimeric antigen receptor T‑cell therapy in pediatric acute lymphoblastic leukemia (Review). Oncol Lett 20: 36, 2020
APA
Fu, Z., Zhou, J., Chen, R., Jin, Y., Ni, T., Qian, L., & Xiao, C. (2020). Cluster of differentiation 19 chimeric antigen receptor T‑cell therapy in pediatric acute lymphoblastic leukemia (Review). Oncology Letters, 20, 36. https://doi.org/10.3892/ol.2020.11897
MLA
Fu, Z., Zhou, J., Chen, R., Jin, Y., Ni, T., Qian, L., Xiao, C."Cluster of differentiation 19 chimeric antigen receptor T‑cell therapy in pediatric acute lymphoblastic leukemia (Review)". Oncology Letters 20.4 (2020): 36.
Chicago
Fu, Z., Zhou, J., Chen, R., Jin, Y., Ni, T., Qian, L., Xiao, C."Cluster of differentiation 19 chimeric antigen receptor T‑cell therapy in pediatric acute lymphoblastic leukemia (Review)". Oncology Letters 20, no. 4 (2020): 36. https://doi.org/10.3892/ol.2020.11897