Open Access

Immune checkpoint inhibitor combination therapy for gastric cancer: Research progress (Review)

  • Authors:
    • Xiaoxu Song
    • Weiwei Qi
    • Jing Guo
    • Libin Sun
    • Aiping Ding
    • Guanghui Zhao
    • Hui Li
    • Wensheng Qiu
    • Jing Lv
  • View Affiliations

  • Published online on: July 24, 2020     https://doi.org/10.3892/ol.2020.11905
  • Article Number: 46
  • Copyright: © Song et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Gastric cancer is one of the most common types of cancer; notably, gastric cancer is one of the top five malignancies with regards to incidence and mortality rates. The symptoms of early gastric cancer are not typical, exhibiting only slight upper abdominal discomfort. When the symptoms become more obvious, the lesion has usually progressed to an advanced stage. Notably, >90% of inpatients already have locally advanced or metastatic gastric cancer at the time of initial diagnosis, with limited treatment options for advanced gastric cancer. These options include chemotherapy, targeted therapy and immune checkpoint inhibitors (ICIs). With regards to ICIs, the clinical benefit of monotherapy for advanced gastric cancer is limited; however, combinations of ICIs and other therapies may have clinical benefit. Relevant clinical studies have demonstrated that combinations of ICIs with chemotherapy, anti‑vascular targeted therapy or other molecular targeted therapies, and the use of two ICIs, improve outcomes for patients with advanced gastric cancer. This article is a review of progress in the use of ICIs in combination with other therapies for the treatment of gastric cancer. The purpose of this article was to advance gastric cancer immunotherapy and to improve the overall therapeutic benefit for patients with advanced gastric cancer.
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October-2020
Volume 20 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Song X, Qi W, Guo J, Sun L, Ding A, Zhao G, Li H, Qiu W and Lv J: Immune checkpoint inhibitor combination therapy for gastric cancer: Research progress (Review). Oncol Lett 20: 46, 2020
APA
Song, X., Qi, W., Guo, J., Sun, L., Ding, A., Zhao, G. ... Lv, J. (2020). Immune checkpoint inhibitor combination therapy for gastric cancer: Research progress (Review). Oncology Letters, 20, 46. https://doi.org/10.3892/ol.2020.11905
MLA
Song, X., Qi, W., Guo, J., Sun, L., Ding, A., Zhao, G., Li, H., Qiu, W., Lv, J."Immune checkpoint inhibitor combination therapy for gastric cancer: Research progress (Review)". Oncology Letters 20.4 (2020): 46.
Chicago
Song, X., Qi, W., Guo, J., Sun, L., Ding, A., Zhao, G., Li, H., Qiu, W., Lv, J."Immune checkpoint inhibitor combination therapy for gastric cancer: Research progress (Review)". Oncology Letters 20, no. 4 (2020): 46. https://doi.org/10.3892/ol.2020.11905