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Long non‑coding RNA metastasis‑associated lung adenocarcinoma transcript 1 regulates renal cancer cell migration via cofilin‑1

  • Authors:
    • Yali Zhang
    • Xinyu Guan
    • Hao Wang
    • Yong Wang
    • Dan Yue
    • Ruibing Chen
  • View Affiliations

  • Published online on: July 27, 2020     https://doi.org/10.3892/ol.2020.11914
  • Article Number: 53
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Long non‑coding RNA (lncRNA) metastasis‑­associated lung adenocarcinoma transcript 1 (MALAT1) is upregulated in numerous types of cancer, and is implicated in various cellular processes associated with cancer progression. However, the underlying molecular mechanisms by which MALAT1 regulates metastasis remain unclear. The present study investigated the expression of MALAT1 across a range of different cancer types by analyzing RNA sequencing data from The Cancer Genome Atlas database. The results indicate that the expression of MALAT1 is highly tissue‑dependent and that MALAT1 is significantly overexpressed in renal clear cell carcinoma (KIRC). The biological role of MALAT1 in regulating KIRC cell migration was further investigated using molecular and cellular assays. The results demonstrate that MALAT1 regulates the expression of cofilin‑1 (CFL1), potentially by regulating RNA splicing. MALAT1 knockdown decreased the expression of CFL1 at both the mRNA and protein levels, and affected cytoskeletal rearrangement by regulating the levels of F‑actin via CFL1, leading to significantly decreased cellular migration. Clinical analysis confirmed a significant correlation between MALAT1 and CFL1 expression, implicating both genes as biomarkers for poor prognosis in KIRC. The present study demonstrates a novel mechanism by which MALAT1 regulates cell migration, which may be exploited to develop novel therapeutic strategies for managing renal cancer metastasis.
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October-2020
Volume 20 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhang Y, Guan X, Wang H, Wang Y, Yue D and Chen R: Long non‑coding RNA metastasis‑associated lung adenocarcinoma transcript 1 regulates renal cancer cell migration via cofilin‑1. Oncol Lett 20: 53, 2020
APA
Zhang, Y., Guan, X., Wang, H., Wang, Y., Yue, D., & Chen, R. (2020). Long non‑coding RNA metastasis‑associated lung adenocarcinoma transcript 1 regulates renal cancer cell migration via cofilin‑1. Oncology Letters, 20, 53. https://doi.org/10.3892/ol.2020.11914
MLA
Zhang, Y., Guan, X., Wang, H., Wang, Y., Yue, D., Chen, R."Long non‑coding RNA metastasis‑associated lung adenocarcinoma transcript 1 regulates renal cancer cell migration via cofilin‑1". Oncology Letters 20.4 (2020): 53.
Chicago
Zhang, Y., Guan, X., Wang, H., Wang, Y., Yue, D., Chen, R."Long non‑coding RNA metastasis‑associated lung adenocarcinoma transcript 1 regulates renal cancer cell migration via cofilin‑1". Oncology Letters 20, no. 4 (2020): 53. https://doi.org/10.3892/ol.2020.11914