MAGE‑A genes as predictors of the outcome of laryngeal squamous cell carcinoma

  • Authors:
    • Shenghui Liu
    • Yan Zhao
    • Yuru Xu
    • Meixiang Sang
    • Ruili Zhao
    • Lina Gu
    • Baoen Shan
  • View Affiliations

  • Published online on: July 29, 2020     https://doi.org/10.3892/ol.2020.11920
  • Article Number: 59
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Abstract

Laryngeal squamous cell carcinoma (LSCC) is one of the most common malignant tumors in the head and neck area. Melanoma‑associated antigens A (MAGE‑A) are strictly tumor‑specific and are expressed in several types of tumors. To date, no studies have reported the potential of MAGE‑A genes as markers for circulating tumor cells (CTCs) in patients with LSCC. The present study aimed to evaluate the expression and the possible prognostic significance of MAGE‑A in the peripheral blood of patients with LSCC. In the present study, the expression of MAGE‑A genes was determined by multiplex semi‑nested PCR and restriction endonuclease treatment of the peripheral blood of patients with LSCC. The association between MAGE‑A gene expression and clinicopathological parameters and prognosis was evaluated. The results demonstrated that the expression of MAGE‑A was associated with the predictors that indicate poor prognosis. The expression levels of MAGE‑A and each individual MAGE‑A gene were also associated with a shorter overall survival time of patients with LSCC. In conclusion, the results of the present study suggested that the expression of MAGE‑A genes may be a potential prognostic marker for patients with LSCC.
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October-2020
Volume 20 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Liu S, Zhao Y, Xu Y, Sang M, Zhao R, Gu L and Shan B: MAGE‑A genes as predictors of the outcome of laryngeal squamous cell carcinoma. Oncol Lett 20: 59, 2020
APA
Liu, S., Zhao, Y., Xu, Y., Sang, M., Zhao, R., Gu, L., & Shan, B. (2020). MAGE‑A genes as predictors of the outcome of laryngeal squamous cell carcinoma. Oncology Letters, 20, 59. https://doi.org/10.3892/ol.2020.11920
MLA
Liu, S., Zhao, Y., Xu, Y., Sang, M., Zhao, R., Gu, L., Shan, B."MAGE‑A genes as predictors of the outcome of laryngeal squamous cell carcinoma". Oncology Letters 20.4 (2020): 59.
Chicago
Liu, S., Zhao, Y., Xu, Y., Sang, M., Zhao, R., Gu, L., Shan, B."MAGE‑A genes as predictors of the outcome of laryngeal squamous cell carcinoma". Oncology Letters 20, no. 4 (2020): 59. https://doi.org/10.3892/ol.2020.11920