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LncRNA‑zinc finger protein 281 downregulates rho‑associated coiled‑coil containing protein kinase 1 by upregulating miR‑144 in osteosarcoma

  • Authors:
    • Yuxiong Shao
    • Zhichao Tong
    • Jianfeng Wei
    • Tuanmin Yang
  • View Affiliations / Copyright

    Affiliations: Department of Bone Disease and Oncology, Honghui Hospital Affiliated to Xi'an Jiaotong University, Xi'an, Shaanxi 710054, P.R. China
    Copyright: © Shao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 79
    |
    Published online on: August 3, 2020
       https://doi.org/10.3892/ol.2020.11940
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Abstract

Zinc finger protein 281 (ZNF281) has been characterized as a tumor suppressive lncRNA in glioma. The present study aimed to analyze the functionality of ZNF281 in osteosarcoma (OS). It was demonstrated that ZNF281 was downregulated in OS tissue specimens and predicted the survival of patients with OS. In tissues from patients with OS, ZNF281 was negatively associated with rho‑associated coiled‑coil containing protein kinase 1 (ROCK1), but positively associated with miR‑144. In the U2OS cell line, ZNF281 overexpression mediated the upregulation of miR‑44 and downregulation of ROCK1. miR‑144 overexpression led to the downregulation of ROCK1, but failed to affect ZNF281. Expression of ZNF281 and miR‑144 resulted in decreased cell migration and invasion, while ROCK1 overexpression resulted in increased invasion and migration of OS cells. In addition, ROCK1 overexpression attenuated the effects of ZNF281 and miR‑144 overexpression. Thus, ZNF281 may downregulate ROCK1 by upregulating miR‑144 and inhibit cancer cell invasion and migration in OS.
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Copy and paste a formatted citation
Spandidos Publications style
Shao Y, Tong Z, Wei J and Yang T: LncRNA‑zinc finger protein 281 downregulates rho‑associated coiled‑coil containing protein kinase 1 by upregulating miR‑144 in osteosarcoma. Oncol Lett 20: 79, 2020.
APA
Shao, Y., Tong, Z., Wei, J., & Yang, T. (2020). LncRNA‑zinc finger protein 281 downregulates rho‑associated coiled‑coil containing protein kinase 1 by upregulating miR‑144 in osteosarcoma. Oncology Letters, 20, 79. https://doi.org/10.3892/ol.2020.11940
MLA
Shao, Y., Tong, Z., Wei, J., Yang, T."LncRNA‑zinc finger protein 281 downregulates rho‑associated coiled‑coil containing protein kinase 1 by upregulating miR‑144 in osteosarcoma". Oncology Letters 20.4 (2020): 79.
Chicago
Shao, Y., Tong, Z., Wei, J., Yang, T."LncRNA‑zinc finger protein 281 downregulates rho‑associated coiled‑coil containing protein kinase 1 by upregulating miR‑144 in osteosarcoma". Oncology Letters 20, no. 4 (2020): 79. https://doi.org/10.3892/ol.2020.11940
Copy and paste a formatted citation
x
Spandidos Publications style
Shao Y, Tong Z, Wei J and Yang T: LncRNA‑zinc finger protein 281 downregulates rho‑associated coiled‑coil containing protein kinase 1 by upregulating miR‑144 in osteosarcoma. Oncol Lett 20: 79, 2020.
APA
Shao, Y., Tong, Z., Wei, J., & Yang, T. (2020). LncRNA‑zinc finger protein 281 downregulates rho‑associated coiled‑coil containing protein kinase 1 by upregulating miR‑144 in osteosarcoma. Oncology Letters, 20, 79. https://doi.org/10.3892/ol.2020.11940
MLA
Shao, Y., Tong, Z., Wei, J., Yang, T."LncRNA‑zinc finger protein 281 downregulates rho‑associated coiled‑coil containing protein kinase 1 by upregulating miR‑144 in osteosarcoma". Oncology Letters 20.4 (2020): 79.
Chicago
Shao, Y., Tong, Z., Wei, J., Yang, T."LncRNA‑zinc finger protein 281 downregulates rho‑associated coiled‑coil containing protein kinase 1 by upregulating miR‑144 in osteosarcoma". Oncology Letters 20, no. 4 (2020): 79. https://doi.org/10.3892/ol.2020.11940
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