Open Access

Eukaryotic translation initiation factor 5A in the pathogenesis of cancers (Review)

  • Authors:
    • Liang Ning
    • Lei Wang
    • Honglai Zhang
    • Xuelong Jiao
    • Dong Chen
  • View Affiliations

  • Published online on: August 3, 2020     https://doi.org/10.3892/ol.2020.11942
  • Article Number: 81
  • Copyright: © Ning et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cancer is the leading cause of death worldwide. The absence of obvious symptoms and insufficiently sensitive biomarkers in early stages of carcinoma limits early diagnosis. Cancer therapy agents and targeted therapy have been used extensively against tissues or organs of specific cancers. However, the intrinsic and/or acquired resistance to the agents or targeted drugs as well as the serious toxic side effects of the drugs would limit their use. Therefore, identifying biomarkers involved in tumorigenesis and progression represents a challenge for cancer diagnosis and therapeutic strategy development. The eukaryotic translation factor 5A (eIF5A), originally identified as an initiation factor, was later shown to promote translation elongation of iterated proline sequences. There are two eIF5A isoforms (eIF5A1 and eIF5A2). eIF5A2 protein consists of 153 residues, and shares 84% amino acid identity with eIF5A1. However, the biological functions of these two isoforms may be significantly different. Recently, it was demonstrated that eIF5Ais widely involved in the pathogenesis of a number of diseases, including cancers. In particular, eIF5A plays an important role in regulating tumor growth, invasion, metastasis and tumor microenvironment. It was also shown to serve as a potential biomarker and target for the diagnosis and treatment of cancers. The present review briefly discusses the latest findings of eIF5A in the pathogenesis of certain malignant cancers and evolving clinical applications.
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October-2020
Volume 20 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Ning L, Wang L, Zhang H, Jiao X and Chen D: Eukaryotic translation initiation factor 5A in the pathogenesis of cancers (Review). Oncol Lett 20: 81, 2020
APA
Ning, L., Wang, L., Zhang, H., Jiao, X., & Chen, D. (2020). Eukaryotic translation initiation factor 5A in the pathogenesis of cancers (Review). Oncology Letters, 20, 81. https://doi.org/10.3892/ol.2020.11942
MLA
Ning, L., Wang, L., Zhang, H., Jiao, X., Chen, D."Eukaryotic translation initiation factor 5A in the pathogenesis of cancers (Review)". Oncology Letters 20.4 (2020): 81.
Chicago
Ning, L., Wang, L., Zhang, H., Jiao, X., Chen, D."Eukaryotic translation initiation factor 5A in the pathogenesis of cancers (Review)". Oncology Letters 20, no. 4 (2020): 81. https://doi.org/10.3892/ol.2020.11942