Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
October-2020 Volume 20 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2020 Volume 20 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

GRB2‑associated binding protein 2 regulates multiple pathways associated with the development of prostate cancer

  • Authors:
    • Xiang-Rui Qiao
    • Xinwei Zhang
    • Lijun Mu
    • Juanhua Tian
    • Yuefeng Du
  • View Affiliations / Copyright

    Affiliations: Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China, Key Laboratory of Environment and Genes Related to Diseases, Xi'an Jiaotong University, Ministry of Education, Xi'an, Shaanxi 710061, P.R. China
    Copyright: © Qiao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 99
    |
    Published online on: August 7, 2020
       https://doi.org/10.3892/ol.2020.11960
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The development of prostate cancer is complicated and involves a number of tumor‑associated gene expression level abnormalities. Gene chip technology is a high‑throughput method that can detect gene expression levels in different tissues and cells on a large scale. In the present study, gene chip technology was used to screen differentially expressed genes in PC‑3 human prostate cancer cells following GRB‑associated binding protein 2 (GAB2) gene knockdown, and the corresponding biological information was analyzed to investigate the role of GAB2 in prostate cancer. The PC‑3 human prostate cancer cell GAB2 gene was knocked out and gene chip hybridization and bioinformatics methods were used to analyze the classical pathway and predict upstream regulatory molecules, disease and function associations and genetic interaction networks. According to the screening conditions |fold change|>1 and P<0.05, 1,242 differential genes were screened; 665 genes were upregulated, and 577 genes were downregulated. Ingenuity Pathway Analysis software demonstrated that GAB2 regulates pathways, such as the superpathway of cholesterol biosynthesis and p53 signaling in cells, and serves a role in diseases and functions such as ‘non‑melanoma solid tumors’, ‘viral infections’ and ‘morbidity or mortality’. In the occurrence and development of prostate cancer, factors such as the activation of genes involved in the proliferative cycle, abnormalities in metabolism‑associated enzyme gene activities and viral infection play key roles. The present study provides novel research directions and therapeutic targets for prostate cancer.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

View References

1 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Yang B, Liao GQ, Wen XF, Chen WH, Cheng S, Stolzenburg JU, Ganzer R and Neuhaus J: Nuclear magnetic resonance spectroscopy as a new approach for improvement of early diagnosis and risk stratification of prostate cancer. J Zhejiang Univ Sci B. 18:921–933. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Ha Chung B, Horie S and Chiong E: The incidence, mortality, and risk factors of prostate cancer in Asian men. Prostate Int. 7:1–8. 2019. View Article : Google Scholar : PubMed/NCBI

4 

Heidenreich A, Aus G, Bolla M, Joniau S, Matveev VB, Schmid HP and Zattoni F; European Association of Urology, : EAU guidelines on prostate cancer. Eur Urol. 53:68–80. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Miyamoto H, Messing EM and Chang C: Androgen deprivation therapy for prostate cancer: Current status and future prospects. Prostate. 61:332–353. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Kirby M, Hirst C and Crawford ED: Characterising the castration-resistant prostate cancer population: A systematic review. Int J Clin Pract. 65:1180–1192. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Souza AG, Bastos VAF, Silva IBB, Marangoni K and Goulart VA: Different gene therapy strategies: A overview for prostate cancer. Curr Gene Ther. 16:287–291. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Vaughan TY, Verma S and Bunting KD: Grb2-associated binding (Gab) proteins in hematopoietic and immune cell biology. Am J Blood Res. 1:130–134. 2011.PubMed/NCBI

9 

Nyga R, Pecquet C, Harir N, Gu H, Dhennin-Duthille I, Régnier A, Gouilleux-Gruart V, Lassoued K and Gouilleux F: Activated STAT5 proteins induce activation of the PI 3-kinase/Akt and Ras/MAPK pathways via the Gab2 scaffolding adapter. Biochem J. 390:359–366. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Brown LA, Kalloger SE, Miller MA, Shih IeM, McKinney SE, Santos JL, Swenerton K, Spellman PT, Gray J, Gilks CB and Huntsman DG: Amplification of 11q13 in ovarian carcinoma. Genes Chromosomes Cancer. 47:481–489. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Zatkova A, Schoch C, Speleman F, Poppe B, Mannhalter C, Fonatsch C and Wimmer K: GAB2 is a novel target of 11q amplification in AML/MDS. Genes Chromosomes Cancer. 45:798–807. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Sármay G, Angyal A, Kertész A, Maus M and Medgyesi D: The multiple function of Grb2 associated binder (Gab) adaptor/scaffolding protein in immune cell signaling. Immunol Lett. 104:76–82. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Liu Y and Rohrschneider LR: The gift of Gab. FEBS Lett. 515:1–7. 2002. View Article : Google Scholar : PubMed/NCBI

14 

Ke Y, Wu D, Princen F, Nguyen T, Pang Y, Lesperance J, Muller WJ, Oshima RG and Feng GS: Role of Gab2 in mammary tumorigenesis and metastasis. Oncogene. 26:4951–4960. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

16 

R Core Team, . R: A language and environment for statistical computing. R Foundation for Statistical Computing (version 3.6.0). (Vienna, Austria). 2019.URL https://www.R-project.org/.

17 

Felciano RM, Bavari S, Richards DR, Billaud JN, Warren T, Panchal R and Krämer A: Predictive systems biology approach to broad-spectrum, host-directed drug target discovery in infectious diseases. Pac Symp Biocomput. 17–28. 2013.PubMed/NCBI

18 

Calvano SE, Xiao W, Richards DR, Felciano RM, Baker HV, Cho RJ, Chen RO, Brownstein BH, Cobb JP, Tschoeke SK, et al: A network-based analysis of systemic inflammation in humans. Nature. 437:1032–1037. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Singal R, Ferdinand L, Reis IM and Schlesselman JJ: Methylation of multiple genes in prostate cancer and the relationship with clinicopathological features of disease. Oncol Rep. 12:631–637. 2004.PubMed/NCBI

20 

Xin-Hong G, Xiao-Cheng J and Liang-Bi C: Gene chip technology and the studies of gene expression profiles. J Biol. 2001.

21 

Singh SK, Banerjee S, Acosta EP, Lillard JW and Singh R: Resveratrol induces cell cycle arrest and apoptosis with docetaxel in prostate cancer cells via a p53/p21WAF1/CIP1 and p27KIP1 pathway. Oncotarget. 8:17216–17228. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Yang T, Espenshade PJ, Wright ME, Yabe D, Gong Y, Aebersold R, Goldstein JL and Brown MS: Crucial step in cholesterol homeostasis: Sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER. Cell. 110:489–500. 2002. View Article : Google Scholar : PubMed/NCBI

23 

Dennis LK, Lynch CF and Torner JC: Epidemiologic association between prostatitis and prostate cancer. Urology. 60:78–83. 2002. View Article : Google Scholar : PubMed/NCBI

24 

Dylgjeri E, McNair C, Goodwin JF, Raymon HK, McCue PA, Shafi AA, Leiby BE, de Leeuw R, Kothari V, McCann JJ, et al: Pleiotropic impact of DNA-PK in cancer and implications for therapeutic strategies. Clin Cancer Res. 25:5623–5637. 2019. View Article : Google Scholar : PubMed/NCBI

25 

Daniels NA, Ewing SK, Zmuda JM, Wilt TJ and Bauer DC; Osteoporotic Fractures in Men (MrOS) research group, : Correlates and prevalence of prostatitis in a large community-based cohort of older men. Urology. 66:964–970. 2005. View Article : Google Scholar : PubMed/NCBI

26 

Jiang J, Li J, Yunxia Z, Zhu H, Liu J and Pumill C: The role of prostatitis in prostate cancer: Meta-analysis. PLoS One. 8:e851792013. View Article : Google Scholar : PubMed/NCBI

27 

Dillner J, Knekt P, Boman J, Lehtinen M, Af Geijersstam V, Sapp M, Schiller J, Maatela J and Aromaa A: Sero-epidemiological association between human-papillomavirus infection and risk of prostate cancer. Int J Cancer. 75:564–567. 1998. View Article : Google Scholar : PubMed/NCBI

28 

Nelson WG, De Marzo AM and Isaacs WB: Prostate cancer. N Engl J Med. 349:366–381. 2003. View Article : Google Scholar : PubMed/NCBI

29 

Taylor ML, Mainous AG III and Wells BJ: Prostate cancer and sexually transmitted diseases: A meta-analysis. Fam Med. 37:506–512. 2005.PubMed/NCBI

30 

Sutcliffe S, Giovannucci E, De Marzo AM, Leitzmann MF, Willett WC and Platz EA: Gonorrhea, syphilis, clinical prostatitis, and the risk of prostate cancer. Cancer Epidemiol Biomarkers Prev. 15:2160–2166. 2006. View Article : Google Scholar : PubMed/NCBI

31 

Wagenlehner FM, Elkahwaji JE, Algaba F, Bjerklund-Johansen T, Naber KG, Hartung R and Weidner W: The role of inflammation and infection in the pathogenesis of prostate carcinoma. BJU Int. 100:733–737. 2007. View Article : Google Scholar : PubMed/NCBI

32 

Cheng I, Witte JS, Jacobsen SJ, Haque R, Quinn VP, Quesenberry CP, Caan BJ and Van Den Eeden SK: Prostatitis, sexually transmitted diseases, and prostate cancer: The California Men's health study. PLoS One. 5:e87362010. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Qiao X, Zhang X, Mu L, Tian J and Du Y: GRB2‑associated binding protein 2 regulates multiple pathways associated with the development of prostate cancer. Oncol Lett 20: 99, 2020.
APA
Qiao, X., Zhang, X., Mu, L., Tian, J., & Du, Y. (2020). GRB2‑associated binding protein 2 regulates multiple pathways associated with the development of prostate cancer. Oncology Letters, 20, 99. https://doi.org/10.3892/ol.2020.11960
MLA
Qiao, X., Zhang, X., Mu, L., Tian, J., Du, Y."GRB2‑associated binding protein 2 regulates multiple pathways associated with the development of prostate cancer". Oncology Letters 20.4 (2020): 99.
Chicago
Qiao, X., Zhang, X., Mu, L., Tian, J., Du, Y."GRB2‑associated binding protein 2 regulates multiple pathways associated with the development of prostate cancer". Oncology Letters 20, no. 4 (2020): 99. https://doi.org/10.3892/ol.2020.11960
Copy and paste a formatted citation
x
Spandidos Publications style
Qiao X, Zhang X, Mu L, Tian J and Du Y: GRB2‑associated binding protein 2 regulates multiple pathways associated with the development of prostate cancer. Oncol Lett 20: 99, 2020.
APA
Qiao, X., Zhang, X., Mu, L., Tian, J., & Du, Y. (2020). GRB2‑associated binding protein 2 regulates multiple pathways associated with the development of prostate cancer. Oncology Letters, 20, 99. https://doi.org/10.3892/ol.2020.11960
MLA
Qiao, X., Zhang, X., Mu, L., Tian, J., Du, Y."GRB2‑associated binding protein 2 regulates multiple pathways associated with the development of prostate cancer". Oncology Letters 20.4 (2020): 99.
Chicago
Qiao, X., Zhang, X., Mu, L., Tian, J., Du, Y."GRB2‑associated binding protein 2 regulates multiple pathways associated with the development of prostate cancer". Oncology Letters 20, no. 4 (2020): 99. https://doi.org/10.3892/ol.2020.11960
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team