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Alteration of the abundance of Parvimonas micra in the gut along the adenoma‑carcinoma sequence

  • Authors:
    • Jun Xu
    • Min Yang
    • Dongyan Wang
    • Shuilong Zhang
    • Su  Yan
    • Yongliang Zhu
    • Weichang Chen
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China, Suzhou Precision Gene Biotechnology Co., Ltd., Suzhou, Jiangsu 215000, P.R. China, Precision Gene, Inc., Fremont, CA 95134, USA
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 106
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    Published online on: August 10, 2020
       https://doi.org/10.3892/ol.2020.11967
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Abstract

Parvimonas micra (P. micra) is reported to be associated with colorectal cancer (CRC). However, its association with colorectal adenoma (CRA) and its role in the initiation of colorectal tumors remain unknown. The present study aimed to clarify the relationship between P. micra and CRA and CRC by exploring the changes of P. micra abundance in an adenoma‑carcinoma sequence in a new cohort and 4 public sequencing datasets. To investigate the alterations of P. micra abundance in the gut along the adenoma‑carcinoma sequence, quantitative PCR (qPCR) was conducted to measure the relative abundance of P. micra in fecal samples from 277 subjects (128 patients with CRA, 66 patients with CRC and 83 healthy individuals, as controls) who underwent colonoscopy as outpatients. Then, the relative abundance of P. micra was analyzed in fecal samples from 596 subjects (185 healthy controls, 158 CRC, 253 CRA) in four public 16S rRNA sequencing datasets. The qPCR results demonstrated that the CRA group had an abundance of P. micra (P=0.2) similar to that of the healthy control group, while the CRC group had a significantly increased abundance (P=8.2x10‑11). The level of P. micra effectively discriminated patients with CRC from healthy controls, while it poorly discriminated patients with CRA from healthy controls; with an area under the receiver operating characteristic curve of 0.867 for patients with CRC and 0.554 for patients with CRA. The same pattern of the alteration of P. micra abundance, which was low in healthy controls and patients with CRA but elevated in patients with CRC, was found in all four public sequencing datasets. These results suggested that P. micra was closely associated with, and may serve as a diagnostic marker for, CRC but not CRA. Moreover, it was indicated that P. micra may be an opportunistic pathogen of CRC, which may promote CRC development but serve a limited role in tumorigenesis.
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Copy and paste a formatted citation
Spandidos Publications style
Xu J, Yang M, Wang D, Zhang S, Yan S, Zhu Y and Chen W: Alteration of the abundance of <em>Parvimonas&nbsp;micra</em> in the gut along the adenoma‑carcinoma sequence. Oncol Lett 20: 106, 2020.
APA
Xu, J., Yang, M., Wang, D., Zhang, S., Yan, S., Zhu, Y., & Chen, W. (2020). Alteration of the abundance of <em>Parvimonas&nbsp;micra</em> in the gut along the adenoma‑carcinoma sequence. Oncology Letters, 20, 106. https://doi.org/10.3892/ol.2020.11967
MLA
Xu, J., Yang, M., Wang, D., Zhang, S., Yan, S., Zhu, Y., Chen, W."Alteration of the abundance of <em>Parvimonas&nbsp;micra</em> in the gut along the adenoma‑carcinoma sequence". Oncology Letters 20.4 (2020): 106.
Chicago
Xu, J., Yang, M., Wang, D., Zhang, S., Yan, S., Zhu, Y., Chen, W."Alteration of the abundance of <em>Parvimonas&nbsp;micra</em> in the gut along the adenoma‑carcinoma sequence". Oncology Letters 20, no. 4 (2020): 106. https://doi.org/10.3892/ol.2020.11967
Copy and paste a formatted citation
x
Spandidos Publications style
Xu J, Yang M, Wang D, Zhang S, Yan S, Zhu Y and Chen W: Alteration of the abundance of <em>Parvimonas&nbsp;micra</em> in the gut along the adenoma‑carcinoma sequence. Oncol Lett 20: 106, 2020.
APA
Xu, J., Yang, M., Wang, D., Zhang, S., Yan, S., Zhu, Y., & Chen, W. (2020). Alteration of the abundance of <em>Parvimonas&nbsp;micra</em> in the gut along the adenoma‑carcinoma sequence. Oncology Letters, 20, 106. https://doi.org/10.3892/ol.2020.11967
MLA
Xu, J., Yang, M., Wang, D., Zhang, S., Yan, S., Zhu, Y., Chen, W."Alteration of the abundance of <em>Parvimonas&nbsp;micra</em> in the gut along the adenoma‑carcinoma sequence". Oncology Letters 20.4 (2020): 106.
Chicago
Xu, J., Yang, M., Wang, D., Zhang, S., Yan, S., Zhu, Y., Chen, W."Alteration of the abundance of <em>Parvimonas&nbsp;micra</em> in the gut along the adenoma‑carcinoma sequence". Oncology Letters 20, no. 4 (2020): 106. https://doi.org/10.3892/ol.2020.11967
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