Open Access

Role of CITED2 in stem cells and cancer (Review)

  • Authors:
    • Beiying An
    • Xufeng Ji
    • Yubao Gong
  • View Affiliations

  • Published online on: August 10, 2020     https://doi.org/10.3892/ol.2020.11968
  • Article Number: 107
  • Copyright: © An et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cbp/P300 interacting transactivator with Glu/Asp‑rich carboxy‑terminal domain 2 (CITED2) is a transcription co‑factor that interacts with several other transcription factors and co‑factors, and serves critical roles in fundamental cell processes, including proliferation, apoptosis, differentiation, migration and autophagy. The interacting transcription factors or co‑factors of CITED2 include LIM homeobox 2, transcription factor AP‑2, SMAD2/3, peroxisome proliferator‑activated receptor γ, oestrogen receptor, MYC, Nucleolin and p300/CBP, which regulate downstream gene expression, and serve important roles in the aforementioned fundamental cell processes. Emerging evidence has demonstrated that CITED2 serves an essential role in embryonic and adult tissue stem cells, including hematopoietic stem cells and tendon‑derived stem/progenitor cells. Additionally, CITED2 has been reported to function in different types of cancer. Although the functions of CITED2 in different tissues vary depending on the interaction partner, altered CITED2 expression or altered interactions with transcription factors or co‑factors result in alterations of fundamental cell processes, and may affect stem cell maintenance or cancer cell survival. The aim of this review is to summarize the molecular mechanisms of CITED2 function and how it serves a role in stem cells and different types of cancer based on the currently available literature.
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October-2020
Volume 20 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
An B, Ji X and Gong Y: Role of CITED2 in stem cells and cancer (Review). Oncol Lett 20: 107, 2020
APA
An, B., Ji, X., & Gong, Y. (2020). Role of CITED2 in stem cells and cancer (Review). Oncology Letters, 20, 107. https://doi.org/10.3892/ol.2020.11968
MLA
An, B., Ji, X., Gong, Y."Role of CITED2 in stem cells and cancer (Review)". Oncology Letters 20.4 (2020): 107.
Chicago
An, B., Ji, X., Gong, Y."Role of CITED2 in stem cells and cancer (Review)". Oncology Letters 20, no. 4 (2020): 107. https://doi.org/10.3892/ol.2020.11968