Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
October-2020 Volume 20 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2020 Volume 20 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Integrated analysis of whole genome and transcriptome sequencing in a young patient with gastric cancer provides insights for precision therapy

  • Authors:
    • Kongwang Hu
    • Weiqiang Yu
    • Olugbenga Emmanuel Ajayi
    • Longlong Li
    • Zhiguo Huang
    • Qiqi Rong
    • Shuaili Wang
    • Qing-Fa Wu
  • View Affiliations / Copyright

    Affiliations: Division of Gastrointestinal Surgery, Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China, Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230026, P.R. China
    Copyright: © Hu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 115
    |
    Published online on: August 12, 2020
       https://doi.org/10.3892/ol.2020.11976
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Gastric cancer is a leading cause of cancer associated deaths worldwide and is considered to be an age‑related disease. In younger patients, gastric cancer is biologically more aggressive, and prognosis is worse compared with that in elderly patients. In the present case report, the whole genome and transcriptome was sequenced in a 26‑year‑old patient with gastric cancer who presented with gastric cancer‑related symptoms and was admitted to the First Affiliated Anhui Medical Hospital (Hefei, China) in December 2016. In total, 9 germline and 4 somatic mutations were identified in the patient, and there were more deleterious sites in the germline mutated genes. Genes with somatic mutations, such as MUC2, MUC4, SLC8A2, and with structural variations, including CCND3, FGFR2 and FGFR3, were found to be differentially expressed. Cancer‑associated pathways, such as the ‘calcium signaling pathway’, ‘cGMP‑PKG signaling pathway’ and ‘transcriptional mis‑regulation’ were also enriched at both the genomic and transcriptomic levels. The genes found to have germline (SFRP4), somatic (MUC2, MUC4, SLC8A2) mutations, or structural variations (CCND3, FGFR2 and FGFR3) were differentially expressed in the patient and could be promising precision therapy targets.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

De Vita F, Di Martino N, Fabozzi A, Laterza MM, Ventriglia J, Savastano B, Petrillo A, Gambardella V, Sforza V, Marano L, et al: Clinical management of advanced gastric cancer: The role of new molecular drugs. World J Gastroentero. 20:14537–14558. 2014. View Article : Google Scholar

2 

Mori M, Sugimachi K, Ohiwa T, Okamura T, Tamura S and Inokuchi K: Early gastric carcinoma in Japanese patients under 30 years of age. Br J Surg. 72:289–291. 1985. View Article : Google Scholar : PubMed/NCBI

3 

Lim S, Lee HS, Kim HS, Kim YI and Kim WH: Alteration of E-cadherin-mediated adhesion protein is common, but microsatellite instability is uncommon in young age gastric cancers. Histopathology. 42:128–136. 2003. View Article : Google Scholar : PubMed/NCBI

4 

Smith BR and Stabile BE: Extreme aggressiveness and lethality of gastric adenocarcinoma in the very young. Arch Surg. 144:506–510. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Quijano Orvananos F, Moreno Paquentin E, Alvarez JJ, Martinez Munive A and Butron Perez L: Gastric carcinoma in patients under 35 years. Rev Gastroenterol Mex. 64:75–77. 1999.(In Spanish). PubMed/NCBI

6 

Theuer CP, Kurosaki T, Taylor TH and Anton-Culver H: Unique features of gastric carcinoma in the young: A population-based analysis. Cancer. 83:25–33. 1998. View Article : Google Scholar : PubMed/NCBI

7 

Wierinckx A, Roche M, Raverot G, Legras-Lachuer C, Croze S, Nazaret N, Rey C, Auger C, Jouanneau E, Chanson P, et al: Integrated genomic profiling identifies loss of chromosome 11p impacting transcriptomic activity in aggressive pituitary PRL Tumors. Brain Pathol. 21:533–543. 2011.PubMed/NCBI

8 

Cancer Genome Atlas Research Network, . Bass AJ, Thorsson V, Shmulevich I, Reynolds SM, Miller M, Bernard B, Hinoue T, Laird PW, Curtis C, et al: Comprehensive molecular characterization of gastric adenocarcinoma. Nature. 513:202–209. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Chmielecki J and Meyerson M: DNA sequencing of cancer: What Have We Learned? Annu Rev Med. 65:63–79. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Garraway LA and Lander ES: Lessons from the Cancer Genome. Cell. 153:17–37. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Vogelstein B, Papadopoulos N, Velculescu VE, Zhou SB, Diaz LA and Kinzler KW: Cancer genome landscapes. Science. 339:1546–1558. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Garraway LA: Genomics-driven oncology: Framework for an emerging paradigm. J Clin Oncol. 31:1806–1814. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Chen R: Abstract 4495: Development and clinical application of an integrative genomic approach to personalized cancer therapy. Cancer Res. 762016.doi: 10.1158/1538-7445.AM2016-4495.

14 

Edge SB and Compton CC: The American Joint Committee on Cancer: The 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol. 17:1471–1474. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Krueger F: Trim Galore: A wrapper tool around Cutadapt and FastQC to consistently apply quality and adapter trimming to FastQ files, with some extra functionality for MspI-digested RRBS-type (Reduced Representation Bisufite-Seq) libraries. 2012.

16 

Dobin A, Davis CA, Schlesinger F, Drenkow J, Zaleski C, Jha S, Batut P, Chaisson M and Gingeras TR: STAR: Ultrafast universal RNA-seq aligner. Bioinformatics. 29:15–21. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Anders S, Pyl PT and Huber W: HTSeq-a Python framework to work with high-throughput sequencing data. Bioinformatics. 31:166–169. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Robinson MD, McCarthy DJ and Smyth GK: edgeR: A Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics. 26:139–140. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Li H: Aligning sequence reads, clone sequences and assembly contigs with BWA-MEM. (Submitted on 16 Mar 2013 (v1), last revised 26 May, 2013 (this version, v2)).

20 

DePristo MA, Banks E, Poplin R, Garimella KV, Maguire JR, Hartl C, Philippakis AA, del Angel G, Rivas MA, et al: A framework for variation discovery and genotyping using next-generation DNA sequencing data. Nat Genet. 43:491–498. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Poplin R, Ruano-Rubio V, DePristo MA, Fennell TJ, Carneiro MO, Van der Auwera GA, Kling DE, Gauthier LD, Levy-Moonshine A, Roazen D, et al: Scaling accurate genetic variant discovery to tens of thousands of samples. BioRxiv. July 24–2017.doi: https://doi.org/10.1101/201178.

22 

Cibulskis K, Lawrence MS, Carter SL, Sivachenko A, Jaffe D, Sougnez C, Gabriel S, Meyerson M, Lander ES and Getz G: Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples. Nat Biotechnol. 31:213–219. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Colaprico A, Silva TC, Olsen C, Garofano L, Cava C, Garolini D, Sabedot TS, Malta TM, Pagnotta SM, Castiglioni I, et al: TCGAbiolinks: An R/Bioconductor package for integrative analysis of TCGA data. Nucleic Acids Res. 44:e712016. View Article : Google Scholar : PubMed/NCBI

24 

1000 Genomes Project Consortium, . Auton A, Brooks LD, Durbin RM, Garrison EP, Kang HM, Korbel JO, Marchini JL, McCarthy S, McVean GA and Abecasis GR: A global reference for human genetic variation. Nature. 526:68–74. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Karczewski KJ, Weisburd B, Thomas B, Solomonson M, Ruderfer DM, Kavanagh D, Hamamsy T, Lek M, Samocha KE, Cummings BB, et al: The ExAC browser: Displaying reference data information from over 60 000 exomes. Nucleic Acids Res. 45:D840–D845. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Karczewski KJ and Karczewski LF: The genome aggregation database (gnomAD). 2017.

27 

Liu X, Wu C, Li C and Boerwinkle E: dbNSFP v3.0: A One-stop database of functional predictions and annotations for human nonsynonymous and splice-site SNVs. Hum Mutat. 37:235–241. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Sherry ST, Ward MH, Kholodov M, Baker J, Phan L, Smigielski EM and Sirotkin K: dbSNP: The NCBI database of genetic variation. Nucleic Acids Res. 29:308–311. 2001. View Article : Google Scholar : PubMed/NCBI

29 

Tate JG, Bamford S, Jubb HC, Sondka Z, Beare DM, Bindal N, Boutselakis H, Cole CG, Creatore C, Dawson E, et al: COSMIC: The catalogue of somatic mutations in cancer. Nucleic Acids Res. 47:D941–D947. 2019. View Article : Google Scholar : PubMed/NCBI

30 

Kimura M: A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide-sequences. J Mol Evol. 16:111–120. 1980. View Article : Google Scholar : PubMed/NCBI

31 

Mwenifumbo JC and Marra MA: Cancer genome-sequencing study design. Nat Rev Genet. 14:321–332. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Shen R and Seshan VE: FACETS: Allele-specific copy number and clonal heterogeneity analysis tool for high-throughput DNA sequencing. Nucleic Acids Res. 44:e1312016. View Article : Google Scholar : PubMed/NCBI

33 

Team RC: R: A language and environment for statistical computing. 2013.

34 

Rausch T, Zichner T, Schlattl A, Stutz AM, Benes V and Korbel JO: DELLY: Structural variant discovery by integrated paired-end and split-read analysis. Bioinformatics. 28:i333–i339. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Dong C, Wei P, Jian X, Gibbs R, Boerwinkle E, Wang K and Liu X: Comparison and integration of deleteriousness prediction methods for nonsynonymous SNVs in whole exome sequencing studies. Hum Mol Genet. 24:2125–2137. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Futreal PA, Coin L, Marshall M, Down T, Hubbard T, Wooster R, Rahman N and Stratton MR: A census of human cancer genes. Nat Rev Cancer. 4:177–183. 2004. View Article : Google Scholar : PubMed/NCBI

37 

Rahman N: Realizing the promise of cancer predisposition genes. Nature. 505:302–308. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Yu GC, Wang LG, Han YY and He QY: clusterProfiler: An R package for comparing biological themes among gene clusters. OMICS. 16:284–287. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES and Mesirov JP: Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA. 102:15545–15550. 2005. View Article : Google Scholar : PubMed/NCBI

40 

Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W and Smyth GK: limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43:e472015. View Article : Google Scholar : PubMed/NCBI

41 

Love MI, Huber W and Anders S: Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 15:5502014. View Article : Google Scholar : PubMed/NCBI

42 

Bailey MH, Tokheim C, Porta-Pardo E, Sengupta S, Bertrand D, Weerasinghe A, Colaprico A, Wendl MC, Kim J, Reardon B, et al: Comprehensive characterization of cancer driver genes and mutations. Cell. 174:1034–1035. 2018. View Article : Google Scholar : PubMed/NCBI

43 

Szász AM, Lánczky A, Nagy Á, Förster S, Hark K, Green JE, Boussioutas A, Busuttil R, Szabó A and Győrffy B: Cross-validation of survival associated biomarkers in gastric cancer using transcriptomic data of 1,065 patients. Oncotarget. 7:49322–49333. 2016. View Article : Google Scholar : PubMed/NCBI

44 

Taiaroa G, Rawlinson D, Featherstone L, et al: Direct RNA sequencing and early evolution of SARS-CoV-2. bioRxiv. 2020.(Epub ahead of print).

45 

He ML, Chen Y, Chen Q, He Y, Zhao J, Wang J, Yang H and Kung HF: Multiple gene dysfunctions lead to high cancer-susceptibility: Evidences from a whole-exome sequencing study. Am J Cancer Res. 1:562–573. 2011.PubMed/NCBI

46 

Zucchelli M, Torkvist L, Bresso F, Halfvarson J, Hellquist A, Anedda F, Assadi G, Lindgren GB, Svanfeldt M, Janson M, et al: PepT1 oligopeptide transporter (SLC15A1) gene polymorphism in inflammatory bowel disease. Inflamm Bowel Dis. 15:1562–1569. 2009. View Article : Google Scholar : PubMed/NCBI

47 

Hodgson A, Parra-Herran C and Mirkovic J: Immunohistochemical expression of HIK1083 and MUC6 in endometrial carcinomas. Histopathology. 75:552–558. 2019. View Article : Google Scholar : PubMed/NCBI

48 

Li M, Huang L, Qiu H, Fu Q, Li W, Yu Q, Sun L, Zhang L, Hu G, Hu J and Yuan X: Helicobacter pylori infection synergizes with three inflammation-related genetic variants in the GWASs to increase risk of gastric cancer in a Chinese population. PLoS One. 8:e749762013. View Article : Google Scholar : PubMed/NCBI

49 

Hierro C, Alsina M, Sanchez M, Serra V, Rodon J and Tabernero J: Targeting the fibroblast growth factor receptor 2 in gastric cancer: Promise or pitfall? Ann Oncol. 28:1207–1216. 2017. View Article : Google Scholar : PubMed/NCBI

50 

Cruciat CM and Niehrs C: Secreted and transmembrane wnt inhibitors and activators. Cold Spring Harb Perspect Biol. 5:a0150812013. View Article : Google Scholar : PubMed/NCBI

51 

Herr P, Hausmann G and Basler K: WNT secretion and signalling in human disease. Trends Mol Med. 18:483–493. 2012. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Hu K, Yu W, Ajayi OE, Li L, Huang Z, Rong Q, Wang S and Wu Q: Integrated analysis of whole genome and transcriptome sequencing in a young patient with gastric cancer provides insights for precision therapy. Oncol Lett 20: 115, 2020.
APA
Hu, K., Yu, W., Ajayi, O.E., Li, L., Huang, Z., Rong, Q. ... Wu, Q. (2020). Integrated analysis of whole genome and transcriptome sequencing in a young patient with gastric cancer provides insights for precision therapy. Oncology Letters, 20, 115. https://doi.org/10.3892/ol.2020.11976
MLA
Hu, K., Yu, W., Ajayi, O. E., Li, L., Huang, Z., Rong, Q., Wang, S., Wu, Q."Integrated analysis of whole genome and transcriptome sequencing in a young patient with gastric cancer provides insights for precision therapy". Oncology Letters 20.4 (2020): 115.
Chicago
Hu, K., Yu, W., Ajayi, O. E., Li, L., Huang, Z., Rong, Q., Wang, S., Wu, Q."Integrated analysis of whole genome and transcriptome sequencing in a young patient with gastric cancer provides insights for precision therapy". Oncology Letters 20, no. 4 (2020): 115. https://doi.org/10.3892/ol.2020.11976
Copy and paste a formatted citation
x
Spandidos Publications style
Hu K, Yu W, Ajayi OE, Li L, Huang Z, Rong Q, Wang S and Wu Q: Integrated analysis of whole genome and transcriptome sequencing in a young patient with gastric cancer provides insights for precision therapy. Oncol Lett 20: 115, 2020.
APA
Hu, K., Yu, W., Ajayi, O.E., Li, L., Huang, Z., Rong, Q. ... Wu, Q. (2020). Integrated analysis of whole genome and transcriptome sequencing in a young patient with gastric cancer provides insights for precision therapy. Oncology Letters, 20, 115. https://doi.org/10.3892/ol.2020.11976
MLA
Hu, K., Yu, W., Ajayi, O. E., Li, L., Huang, Z., Rong, Q., Wang, S., Wu, Q."Integrated analysis of whole genome and transcriptome sequencing in a young patient with gastric cancer provides insights for precision therapy". Oncology Letters 20.4 (2020): 115.
Chicago
Hu, K., Yu, W., Ajayi, O. E., Li, L., Huang, Z., Rong, Q., Wang, S., Wu, Q."Integrated analysis of whole genome and transcriptome sequencing in a young patient with gastric cancer provides insights for precision therapy". Oncology Letters 20, no. 4 (2020): 115. https://doi.org/10.3892/ol.2020.11976
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team