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Review

Challenges surrounding postoperative adjuvant chemotherapy for T2N0 gastric cancer (Review)

  • Authors:
    • Ke-Kang Sun
    • Qing-Hua Wang
    • Yong-You Wu
  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal Surgery, Affiliated Kunshan Hospital to Jiangsu University, Suzhou, Jiangsu 215300, P.R. China, Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215008, P.R. China
  • Article Number: 126
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    Published online on: August 19, 2020
       https://doi.org/10.3892/ol.2020.11985
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Abstract

Determining the requirement for adjuvant chemotherapy in patients with stage IB gastric cancer (GC), and particularly for those with stage T2N0 (muscularis propria) disease, remains challenging. Patients with stage II/III disease benefit from postoperative adjuvant therapy; however, the randomized trials examining whether such therapy affords any survival benefit to patients with T2N0 disease are not sufficient. Current evidence suggests that not all patients with T2N0 disease should undergo such treatment, but only those with a high risk. To date, a number of retrospective studies have attempted to identify factors that are predictive of increased risk in an effort to guide adjuvant therapy‑related clinical decision making. The National Comprehensive Cancer Network and the Chinese Society of Clinical Oncology have published guidelines regarding factors associated with increased patient risk. As a result, treatment decisions for patients with stage T2N0 disease are currently determined on an individualized basis, in light of risk factors and the potential benefits of treatment. The present review surveyed current evidence related to the treatment of patients with high‑risk GC and highlighted the potential avenues for future investigated.
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1 

Macdonald JS, Smalley SR, Benedetti J, Hundahl SA, Estes NC, Stemmermann GN, Haller DG, Ajani JA, Gunderson LL, Jessup JM and Martenson JA: Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction. N Engl J Med. 345:725–730. 2001. View Article : Google Scholar : PubMed/NCBI

2 

Seeruttun SR, Yuan S, Qiu H, Huang Y, Li Y, Liang Y, Guan Y, Zhan Y, Li W, Chen Y, et al: A comprehensive analysis comparing the eighth AJCC gastric cancer pathological classification to the seventh, sixth, and fifth editions. Cancer Med. 6:2804–2813. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Sakuramoto S, Sasako M, Yamaguchi T, Kinoshita T, Fujii M, Nashimoto A, Furukawa H, Nakajima T, Ohashi Y, Imamura H, et al: Adjuvant chemotherapy for gastric cancer with S-1, an oral fluoropyrimidine. N Engl J Med. 357:1810–1820. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Bang YJ, Kim YW, Yang HK, Chung HC, Park YK, Lee KH, Lee KW, Kim YH, Noh SI, Cho JY, et al: Adjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): A phase 3 open-label, randomised controlled trial. Lancet. 379:315–321. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Japanese Gastric Cancer Association, . Japanese gastric cancer treatment guidelines 2014 (ver. 4). Gastric Cancer. 20:1–19. 2017. View Article : Google Scholar

6 

Smyth EC, Verheij M, Allum W, Cunningham D, Cervantes A and Arnold D; ESMO Guidelines Committee, : Gastric cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 27 (Suppl 5):v38S–v49S. 2016. View Article : Google Scholar

7 

Ajani JA, D'Amico TA, Baggstrom M, et al: Gastric cancer, version 5.2017. NCCN Clinical Practice Guidelines in Oncology. 14:1286–1312. 2017.

8 

Wang FH, Shen L, Li J, Zhou ZW, Liang H, Zhang XT, Tang L, Xin Y, Jin J, Zhang YJ, et al: The chinese society of clinical oncology (CSCO): Clinical guidelines for the diagnosis and treatment of gastric cancer. Cancer Commun (Lond). 39:102019. View Article : Google Scholar : PubMed/NCBI

9 

Smalley SR, Benedetti JK, Haller DG, Hundahl SA, Estes NC, Ajani JA, Gunderson LL, Goldman B, Martenson JA, Jessup JM, et al: Updated analysis of SWOG-directed intergroup study 0116: A phase III trial of adjuvant radiochemotherapy versus observation after curative gastric cancer resection. J Clin Oncol. 30:2327–2333. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Hundahl SA, Macdonald JS, Benedetti J and Fitzsimmons T; Southwest Oncology Group and the Gastric Intergroup, : Surgical treatment variation in a prospective, randomized trial of chemoradiotherapy in gastric cancer: The effect of undertreatment. Ann Surg Oncol. 9:278–286. 2002. View Article : Google Scholar : PubMed/NCBI

11 

Choi KH and Kim BS, Oh ST, Yook JH and Kim BS: Comparison the sixth and seventh editions of the AJCC staging system for T1 gastric cancer: A long-term follow-up study of 2124 patients. Gastric Cancer. 20:43–48. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Lee J, Lim DH, Kim S, Park SH, Park JO, Park YS, Lim HY, Choi MG, Sohn TS, Noh JH, et al: Phase III trial comparing capecitabine plus cisplatin versus capecitabine plus cisplatin with concurrent capecitabine radiotherapy in completely resected gastric cancer with D2 lymph node dissection: The ARTIST trial. J Clin Oncol. 30:268–273. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Park SH, Sohn TS, Lee J, Lim DH, Hong ME, Kim KM, Sohn I, Jung SH, Choi MG, Lee JH, et al: Phase III trial to compare adjuvant chemotherapy with capecitabine and cisplatin versus concurrent chemoradiotherapy in gastric cancer: Final report of the adjuvant chemoradiotherapy in stomach tumors trial, including survival and subset analyses. J Clin Oncol. 33:3130–3136. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Kim Y, Kim KM, Choi MG, Lee JH, Sohn TS, Bae JM, Kim S, Lee SJ, Kim ST, Lee J, et al: Adjuvant chemotherapy with or without concurrent radiotherapy for patients with stage IB gastric cancer: A subgroup analysis of the adjuvant chemoradiotherapy in stomach tumors (ARTIST) phase III trial. J Gastric Cancer. 18:348–355. 2018. View Article : Google Scholar : PubMed/NCBI

15 

Coburn NG, Govindarajan A, Law CH, Guller U, Kiss A, Ringash J, Swallow CJ and Baxter NN: Stage-specific effect of adjuvant therapy following gastric cancer resection: A population-based analysis of 4,041 patients. Ann Surg Oncol. 15:500–507. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Japanese Gastric Cancer Association, . Japanese classification of gastric carcinoma-2nd english edition. Gastric Cancer. 1:10–24. 1998. View Article : Google Scholar : PubMed/NCBI

17 

Sasako M, Sakuramoto S, Katai H, Kinoshita T, Furukawa H, Yamaguchi T, Nashimoto A, Fujii M, Nakajima T and Ohashi Y: Five-year outcomes of a randomized phase III trial comparing adjuvant chemotherapy with S-1 versus surgery alone in stage II or III gastric cancer. J Clin Oncol. 29:4387–4393. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Noh SH, Park SR, Yang HK, Chung HC, Chung IJ, Kim SW, Kim HH, Choi JH, Kim HK, Yu W, et al: Adjuvant capecitabine plus oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): 5-year follow-up of an open-label, randomised phase 3 trial. Lancet Oncol. 15:1389–1396. 2014. View Article : Google Scholar : PubMed/NCBI

19 

GASTRIC (Global Advanced/Adjuvant Stomach Tumor Research International Collaboration) Group, ; Paoletti X, Oba K, Burzykowski T, Michiels S, Ohashi Y, Pignon JP, Rougier P, Sakamoto J, Sargent D, et al: Benefit of adjuvant chemotherapy for resectable gastric cancer: A meta-analysis. JAMA. 303:1729–1737. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Dudeja V, Habermann EB, Abraham A, Zhong W, Parsons HM, Tseng JF and Al-Refaie WB: Is there a role for surgery with adequate nodal evaluation alone in gastric adenocarcinoma? J Gastrointest Surg. 16:238–247. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Seyedin S, Wang PC, Zhang Q and Lee P: Benefit of adjuvant chemoradiotherapy for gastric adenocarcinoma: A SEER population analysis. Gastrointest Cancer Res. 7:82–90. 2014.PubMed/NCBI

22 

Datta J, McMillan MT, Ruffolo L, Lowenfeld L, Mamtani R, Plastaras JP, Dempsey DT, Karakousis GC, Drebin JA, Fraker DL and Roses RE: Multimodality therapy improves survival in resected early stage gastric cancer in the United States. Ann Surg Oncol. 23:2936–2945. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Wang Z, Yan J, Hu W, Zhang J and Huo B: Adjuvant chemotherapy provided survival benefit for stage T2N0 gastric cancer with high-risk factors. Neoplasma. 65:592–598. 2018. View Article : Google Scholar : PubMed/NCBI

24 

Du C, Zhou Y, Huang K, Zhao G, Fu H and Shi Y: Defining a high-risk subgroup of pathological T2N0 gastric cancer by prognostic risk stratification for adjuvant therapy. J Gastrointest Surg. 15:2153–2158. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Park JH, Ryu MH, Kim HJ, Ryoo BY, Yoo C, Park I, Park YS, Oh ST, Yook JH, Kim BS and Kang YK: Risk factors for selection of patients at high risk of recurrence or death after complete surgical resection in stage I gastric cancer. Gastric Cancer. 19:226–233. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Hwang JE, Hong JY, Kim JE, Shim HJ, Bae WK, Hwang EC, Jeong O, Park YK, Lee KH, Lee JH, et al: Prognostic significance of the concomitant existence of lymphovascular and perineural invasion in locally advanced gastric cancer patients who underwent curative gastrectomy and adjuvant chemotherapy. Jpn J Clin Oncol. 45:541–546. 2015.PubMed/NCBI

27 

Araki I, Hosoda K, Yamashita K, Katada N, Sakuramoto S, Moriya H, Mieno H, Ema A, Kikuchi S, Mikami T and Watanabe M: Prognostic impact of venous invasion in stage IB node-negative gastric cancer. Gastric Cancer. 18:297–305. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Yokoyama T, Kamada K, Tsurui Y, Kashizuka H, Okano E, Ogawa S, Obara S and Tatsumi M: Clinicopathological analysis for recurrence of stage Ib gastric cancer (according to the second english edition of the Japanese classification of gastric carcinoma). Gastric Cancer. 14:372–377. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Ohtsu A and Sasako M: Overview of adjuvant therapy for resected gastric cancer: Differences in Japan and the United States. Semin Oncol. 32 (6 Suppl 9):S101–S104. 2005. View Article : Google Scholar : PubMed/NCBI

30 

Wang Y, Zhang J, Guo S, Dong Z, Meng X, Zheng G, Yang D, Zheng Z and Zhao Y: Implication of lymph node staging in migration and different treatment strategies for stage T2N0M0 and T1N1M0 resected gastric cancer: A SEER population analysis. Clin Transl Oncol. 21:1499–1509. 2019. View Article : Google Scholar : PubMed/NCBI

31 

In H, Kantor O, Sharpe SM, Baker MS, Talamonti MS and Posner MC: Adjuvant therapy improves survival for T2N0 gastric cancer patients with sub-optimal lymphadenectomy. Ann Surg Oncol. 23:1956–1962. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Aoyama T, Yoshikawa T, Fujikawa H, Hayashi T, Ogata T, Cho H, Yamada T, Hasegawa S, Tsuchida K, Yukawa N, et al: Prognostic factors in stage IB gastric cancer. World J Gastroenterol. 20:6580–6585. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Sunakawa Y and Lenz HJ: Molecular classification of gastric adenocarcinoma: Translating new insights from the cancer genome atlas research network. Curr Treat Options Oncol. 16:172015. View Article : Google Scholar : PubMed/NCBI

34 

Polom K, Marano L, Marrelli D, De Luca R, Roviello G, Savelli V, Tan P and Roviello F: Meta-analysis of microsatellite instability in relation to clinicopathological characteristics and overall survival in gastric cancer. Br J Surg. 105:159–167. 2018. View Article : Google Scholar : PubMed/NCBI

35 

Choi YY, Kim H, Shin SJ, Kim HY, Lee J, Yang HK, Kim WH, Kim YW, Kook MC, Park YK, et al: Microsatellite instability and programmed cell death-ligand 1 expression in stage II/III gastric cancer: Post hoc analysis of the CLASSIC randomized controlled study. Ann Surg. 270:309–316. 2019. View Article : Google Scholar : PubMed/NCBI

36 

Miceli R, An J, Di Bartolomeo M, Morano F, Kim ST, Park SH, Choi MG, Lee JH, Raimondi A, Fucà G, et al: Prognostic impact of microsatellite instability in asian gastric cancer patients enrolled in the ARTIST trial. Oncology. 97:38–43. 2019. View Article : Google Scholar : PubMed/NCBI

37 

Dai D, Zhao X, Li X, Shu Y, Shen B, Chen X, Chen D and Wang D: Association between the microsatellite instability status and the efficacy of postoperative adjuvant chemoradiotherapy in patients with gastric cancer. Front Oncol. 9:14522020. View Article : Google Scholar : PubMed/NCBI

38 

Lordick F: Chemotherapy for resectable microsatellite instability-high gastric cancer? Lancet Oncol. 21:2032020. View Article : Google Scholar : PubMed/NCBI

39 

Van't Veer LJ, Dai H, van de Vijver MJ, He YD, Hart AA, Mao M, Peterse HL, van der Kooy K, Marton MJ, Witteveen AT, et al: Gene expression profiling predicts clinical outcome of breast cancer. Nature. 415:530–536. 2002. View Article : Google Scholar : PubMed/NCBI

40 

Nakamura K, Hatakeyama K, Furukawa K, Fujiya K, Kamiya S, Hikage M, Tanizawa Y, Bando E, Ohshima K, Urakami K, et al: Prediction of S-1 adjuvant chemotherapy benefit in stage II/III gastric cancer treatment based on comprehensive gene expression analysis. Gastric Cancer. 23:648–658. 2020. View Article : Google Scholar : PubMed/NCBI

41 

Cheong JH, Yang HK, Kim H, Kim WH, Kim YW, Kook MC, Park YK, Kim HH, Lee HS, Lee KH, et al: Predictive test for chemotherapy response in resectable gastric cancer: A multi-cohort, retrospective analysis. Lancet Oncol. 19:629–638. 2018. View Article : Google Scholar : PubMed/NCBI

42 

Roskoski R Jr: The ErbB/HER family of protein-tyrosine kinases and cancer. Pharmacol Res. 79:34–74. 2014. View Article : Google Scholar : PubMed/NCBI

43 

Begnami MD, Fukuda E, Fregnani JH, Nonogaki S, Montagnini AL, da Costa WL Jr and Soares FA: Prognostic implications of altered human epidermal growth factor receptors (HERs) in gastric carcinomas: HER2 and HER3 are predictors of poor outcome. J Clin Oncol. 29:3030–3036. 2011. View Article : Google Scholar : PubMed/NCBI

44 

Wang S, Zheng G, Chen L and Xiong B: Effect of HER-2/neu over-expression on prognosis in gastric cancer: A meta-analysis. Asian Pac J Cancer Prev. 12:1417–1423. 2011.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Sun K, Wang Q and Wu Y: Challenges surrounding postoperative adjuvant chemotherapy for T2N0 gastric cancer (Review). Oncol Lett 20: 126, 2020.
APA
Sun, K., Wang, Q., & Wu, Y. (2020). Challenges surrounding postoperative adjuvant chemotherapy for T2N0 gastric cancer (Review). Oncology Letters, 20, 126. https://doi.org/10.3892/ol.2020.11985
MLA
Sun, K., Wang, Q., Wu, Y."Challenges surrounding postoperative adjuvant chemotherapy for T2N0 gastric cancer (Review)". Oncology Letters 20.5 (2020): 126.
Chicago
Sun, K., Wang, Q., Wu, Y."Challenges surrounding postoperative adjuvant chemotherapy for T2N0 gastric cancer (Review)". Oncology Letters 20, no. 5 (2020): 126. https://doi.org/10.3892/ol.2020.11985
Copy and paste a formatted citation
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Spandidos Publications style
Sun K, Wang Q and Wu Y: Challenges surrounding postoperative adjuvant chemotherapy for T2N0 gastric cancer (Review). Oncol Lett 20: 126, 2020.
APA
Sun, K., Wang, Q., & Wu, Y. (2020). Challenges surrounding postoperative adjuvant chemotherapy for T2N0 gastric cancer (Review). Oncology Letters, 20, 126. https://doi.org/10.3892/ol.2020.11985
MLA
Sun, K., Wang, Q., Wu, Y."Challenges surrounding postoperative adjuvant chemotherapy for T2N0 gastric cancer (Review)". Oncology Letters 20.5 (2020): 126.
Chicago
Sun, K., Wang, Q., Wu, Y."Challenges surrounding postoperative adjuvant chemotherapy for T2N0 gastric cancer (Review)". Oncology Letters 20, no. 5 (2020): 126. https://doi.org/10.3892/ol.2020.11985
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