search button
Open Access

Long intergenic non‑protein coding RNA‑467 targets microRNA‑451a in human colorectal cancer

  • Authors:
    • Yang Bai
    • Haiyan Wu
    • Bin Han
    • Ke Xu
    • Yuanqi Liu
    • Yin  Liu
    • Shikun Miao
    • Yuanyuan Zhang
    • Liming Zhou

  • View Affiliations

  • Published online on: August 19, 2020     https://doi.org/10.3892/ol.2020.11987
  • Article Number: 124

  • Copyright: © Bai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Accumulating evidence has demonstrated that long non‑coding RNAs (lncRNAs) are frequently overexpressed in colorectal cancer (CRC). However, few related lncRNA signatures have been established for predicting CRC metastasis. The purpose of the present study was to identify lncRNAs that serve key roles in the metastasis of human CRC, and their potential downstream targets. A total of 31 human CRC biopsy samples were collected, and the expression of long intergenic non‑protein coding RNA‑467 (linc00467) and its association with clinical characteristics were evaluated. Consequently, linc00467 was revealed to be overexpressed in human CRC tissues, and its expression was significantly associated with metastasis and Tumor‑Node‑Metastasis stage. In HT29 and HCT116 cells, linc00467‑knockout was revealed to decrease cellular proliferation and increase apoptosis (P<0.05). Finally, the downstream target of linc00467 in CRC promotion was predicted using bioinformatics analysis. The results demonstrated that linc00467 targets and regulates the expression of microRNA (miR)‑451a, promoting carcinogenesis and metastasis in CRC. In conclusion, the results of the present study indicate that increased linc00467 expression promotes metastasis by targeting miR‑451a, which ultimately increases cellular proliferation and inhibits apoptosis in human CRC cells.
View Figures
View References

Related Articles

Journal Cover

November-2020
Volume 20 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

  • Journal Metrics
  • Impact Factor: 2.9
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 6.3
  • CiteScore Rank: Q2: #119/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.725
  • SCImago Journal Rank (SJR): 0.639
International Symposium on Molecular Medicine Conference Banner
The Cancer Story
World Congress on Advances in Oncology and International Symposium on Molecular Medicine Conference Banner
World Academy Of Sciences Banner
Heyday Road Banner

0

Copy and paste a formatted citation
x
Spandidos Publications style
Bai Y, Wu H, Han B, Xu K, Liu Y, Liu Y, Miao S, Zhang Y and Zhou L: Long intergenic non‑protein coding RNA‑467 targets microRNA‑451a in human colorectal cancer. Oncol Lett 20: 124, 2020
APA
Bai, Y., Wu, H., Han, B., Xu, K., Liu, Y., Liu, Y. ... Zhou, L. (2020). Long intergenic non‑protein coding RNA‑467 targets microRNA‑451a in human colorectal cancer. Oncology Letters, 20, 124. https://doi.org/10.3892/ol.2020.11987
MLA
Bai, Y., Wu, H., Han, B., Xu, K., Liu, Y., Liu, Y., Miao, S., Zhang, Y., Zhou, L."Long intergenic non‑protein coding RNA‑467 targets microRNA‑451a in human colorectal cancer". Oncology Letters 20.5 (2020): 124.
Chicago
Bai, Y., Wu, H., Han, B., Xu, K., Liu, Y., Liu, Y., Miao, S., Zhang, Y., Zhou, L."Long intergenic non‑protein coding RNA‑467 targets microRNA‑451a in human colorectal cancer". Oncology Letters 20, no. 5 (2020): 124. https://doi.org/10.3892/ol.2020.11987