Open Access

Effects of lncRNA TUSC7 on the malignant biological behavior of osteosarcoma cells via regulation of miR‑375

  • Authors:
    • Lulu Wang
    • Jiankui Jiang
    • Guisen Sun
    • Panpan Zhang
    • Ya Li
  • View Affiliations

  • Published online on: August 20, 2020     https://doi.org/10.3892/ol.2020.11994
  • Article Number: 133
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The present study aimed at investigating how long‑chain non‑coding RNA (lncRNA) tumor suppressor candidate 7 (TUSC7) regulates the malignant biological behavior of osteosarcoma cells. Tumor tissues and adjacent tissues of 30 patients with osteosarcoma were collected, and the expression levels of lncRNA TUSC7 and miR‑375 were detected by RT‑qPCR. lncRNA TUSC7 mimic and miR‑375 mimic transfection models were established in MG63 osteosarcoma cells, and Transwell assays were used to detect the migration ability of MG63 cells. An MTT assay was used to assess the proliferation ability of MG63 cells. lncRNA TUSC7 in osteosarcoma tissue was significantly lower than that of adjacent tissues, while miR‑375 levels were significantly higher than that of adjacent tissues; the two levels have a negative correlation. lncRNA TUSC7 mimic inhibited MG63 proliferation and migration abilities. miR‑375 mimic promoted MG63 proliferation and migration abilities. The lncRNA TUSC7 mimic and miR‑375 mimic co‑transfection system could partially rescue the inhibition of lncRNA TUSC7 mimic on MG63 cells. In conclusion, lncRNA TUSC7 inhibited the proliferation and migration of MG63 osteosarcoma cells by regulating miR‑375.
View Figures
View References

Related Articles

Journal Cover

November-2020
Volume 20 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Wang L, Jiang J, Sun G, Zhang P and Li Y: Effects of lncRNA TUSC7 on the malignant biological behavior of osteosarcoma cells via regulation of miR‑375. Oncol Lett 20: 133, 2020
APA
Wang, L., Jiang, J., Sun, G., Zhang, P., & Li, Y. (2020). Effects of lncRNA TUSC7 on the malignant biological behavior of osteosarcoma cells via regulation of miR‑375. Oncology Letters, 20, 133. https://doi.org/10.3892/ol.2020.11994
MLA
Wang, L., Jiang, J., Sun, G., Zhang, P., Li, Y."Effects of lncRNA TUSC7 on the malignant biological behavior of osteosarcoma cells via regulation of miR‑375". Oncology Letters 20.5 (2020): 133.
Chicago
Wang, L., Jiang, J., Sun, G., Zhang, P., Li, Y."Effects of lncRNA TUSC7 on the malignant biological behavior of osteosarcoma cells via regulation of miR‑375". Oncology Letters 20, no. 5 (2020): 133. https://doi.org/10.3892/ol.2020.11994