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Article Open Access

Upregulation of cervical carcinoma expressed PCNA regulatory long non‑coding RNA promotes esophageal squamous cell carcinoma progression

Retraction in: /10.3892/ol.2025.15380
  • Authors:
    • Xiaojun Wang
    • Liangfen Zhou
    • Huiyun Zhang
    • Hui Ou
    • Wenxing Long
    • Xiaobao Liu
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, First People's Hospital of Chenzhou City, Chenzhou, Hunan 423000, P.R. China, Department of Neonatology, First People's Hospital of Chenzhou City, Chenzhou, Hunan 423000, P.R. China, Department of Invasive Technology, Affiliated Hospital of Xiangnan College, Chenzhou, Hunan 423000, P.R. China, Department of Oncology, Second People's Hospital of Chenzhou City, Chenzhou, Hunan 423000, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 142
    |
    Published online on: August 21, 2020
       https://doi.org/10.3892/ol.2020.12006
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Abstract

Cervical carcinoma expressed PCNA regulatory long non‑coding (lnc)RNA (CCEPR) has recently been reported to play oncogenic roles in some common types of human cancer. However, the clinical significance of CCEPR mRNA expression levels in esophageal squamous cell carcinoma (ESCC) and the exact function of CCEPR in regulating the malignant phenotypes of ESCC cells have not been previously investigated. In the present study, CCEPR mRNA expression level was upregulated in ESCC tissues and cell lines, and overexpression of CCEPR was associated with advanced TNM stage, lymph node metastasis, and poor prognosis in ESCC. In vitro experiments showed that silencing CCEPR mRNA expression levels significantly suppressed the proliferation, migration, and invasion of ESCC cells, while inducing ESCC cell apoptosis. Furthermore, inhibition of CCEPR decreased the protein expression levels of matrix metalloproteinase (MMP)2 and MMP9 and inhibited epithelial‑mesenchymal transition in ESCC cells. In conclusion, the results showed that CCEPR plays an oncogenic role in ESCC and suggests that CCEPR could be used as a potential therapeutic target for ESCC treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Wang X, Zhou L, Zhang H, Ou H, Long W and Liu X: Upregulation of cervical carcinoma expressed PCNA regulatory long non‑coding RNA promotes esophageal squamous cell carcinoma progression Retraction in /10.3892/ol.2025.15380. Oncol Lett 20: 142, 2020.
APA
Wang, X., Zhou, L., Zhang, H., Ou, H., Long, W., & Liu, X. (2020). Upregulation of cervical carcinoma expressed PCNA regulatory long non‑coding RNA promotes esophageal squamous cell carcinoma progression Retraction in /10.3892/ol.2025.15380. Oncology Letters, 20, 142. https://doi.org/10.3892/ol.2020.12006
MLA
Wang, X., Zhou, L., Zhang, H., Ou, H., Long, W., Liu, X."Upregulation of cervical carcinoma expressed PCNA regulatory long non‑coding RNA promotes esophageal squamous cell carcinoma progression Retraction in /10.3892/ol.2025.15380". Oncology Letters 20.5 (2020): 142.
Chicago
Wang, X., Zhou, L., Zhang, H., Ou, H., Long, W., Liu, X."Upregulation of cervical carcinoma expressed PCNA regulatory long non‑coding RNA promotes esophageal squamous cell carcinoma progression Retraction in /10.3892/ol.2025.15380". Oncology Letters 20, no. 5 (2020): 142. https://doi.org/10.3892/ol.2020.12006
Copy and paste a formatted citation
x
Spandidos Publications style
Wang X, Zhou L, Zhang H, Ou H, Long W and Liu X: Upregulation of cervical carcinoma expressed PCNA regulatory long non‑coding RNA promotes esophageal squamous cell carcinoma progression Retraction in /10.3892/ol.2025.15380. Oncol Lett 20: 142, 2020.
APA
Wang, X., Zhou, L., Zhang, H., Ou, H., Long, W., & Liu, X. (2020). Upregulation of cervical carcinoma expressed PCNA regulatory long non‑coding RNA promotes esophageal squamous cell carcinoma progression Retraction in /10.3892/ol.2025.15380. Oncology Letters, 20, 142. https://doi.org/10.3892/ol.2020.12006
MLA
Wang, X., Zhou, L., Zhang, H., Ou, H., Long, W., Liu, X."Upregulation of cervical carcinoma expressed PCNA regulatory long non‑coding RNA promotes esophageal squamous cell carcinoma progression Retraction in /10.3892/ol.2025.15380". Oncology Letters 20.5 (2020): 142.
Chicago
Wang, X., Zhou, L., Zhang, H., Ou, H., Long, W., Liu, X."Upregulation of cervical carcinoma expressed PCNA regulatory long non‑coding RNA promotes esophageal squamous cell carcinoma progression Retraction in /10.3892/ol.2025.15380". Oncology Letters 20, no. 5 (2020): 142. https://doi.org/10.3892/ol.2020.12006
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