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The value of 18F‑FDG PET/CT in the prediction of clinical outcomes of patients with acute leukemia treated with allogeneic hematopoietic stem cell transplantation

  • Authors:
    • Zixuan Zhao
    • Yeye Zhou
    • Jing Wang
    • Tongtong Zhang
    • Jihui Li
    • Bin Zhang
    • Qingru Li
    • Shengming Deng
  • View Affiliations / Copyright

    Affiliations: Department of Nuclear Medicine, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China, Department of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 175
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    Published online on: August 31, 2020
       https://doi.org/10.3892/ol.2020.12036
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Abstract

The present study aimed to determine whether 18F‑FDG PET/CT performed before and/or after allogeneic hematopoietic stem cell transplantation (allo‑HSCT) can predict clinical outcomes in acute leukemia (AL). A total of 79 examinations comprising 72 patients with AL who underwent 18F‑FDG PET/CT before and/or after allo‑HSCT were retrospectively enrolled between January 2011 and January 2019. Outcomes were assessed using overall survival (OS) and disease‑free survival (DFS). A total of 63 examinations were PET‑positive, while 16 examinations were PET‑negative. Increased BM and splenic 18F‑FDG uptake were observed in 24 (19/79) and 14% (11/79) of examinations, respectively. 18F‑FDG‑avid lymph nodes were observed in 38% (30/79) of examinations. ENEMES involvement was detected in 44% (35/79) of examinations. The presence of ENEMES involvement [OS hazard ratio (HR), 6.399; 95% confidence interval (CI), 1.843‑22.224; P=0.003; post‑HSCT OS: HR, 7.203; 95% CI, 1.510‑34.369; P=0.013; DFS HR, 3.671; 95% CI, 1.145‑11.768; P=0.029], post‑transplantation minimal residual disease (DFS HR, 4.381; 95% CI, 1.594‑12.040; P=0.004; pre‑HSCT OS HR, 11.455; 95% CI, 1.336‑98.179; P=0.026) and disease status (OS HR, 0.330; 95% CI, 0.128‑0.848; P=0.021; post‑HSCT OS HR, 0.195; 95% CI, 0.050‑0.762; P=0.019; DFS: HR, 0.278; 95% CI, 0.091‑0.851; P=0.025) could serve as an adverse prognostic factor in patients with AL treated with allo‑HSCT. 18F‑FDG PET/CT before and/or after allo‑HSCT was a predictor for OS and DFS in patients with AL. ENEMES involvement detected using 18F‑FDG PET/CT may help identify patients with AL who are likely to have unfavorable clinical outcomes.
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Copy and paste a formatted citation
Spandidos Publications style
Zhao Z, Zhou Y, Wang J, Zhang T, Li J, Zhang B, Li Q and Deng S: The value of <sup>18</sup>F‑FDG PET/CT in the prediction of clinical outcomes of patients with acute leukemia treated with allogeneic hematopoietic stem cell transplantation. Oncol Lett 20: 175, 2020.
APA
Zhao, Z., Zhou, Y., Wang, J., Zhang, T., Li, J., Zhang, B. ... Deng, S. (2020). The value of <sup>18</sup>F‑FDG PET/CT in the prediction of clinical outcomes of patients with acute leukemia treated with allogeneic hematopoietic stem cell transplantation. Oncology Letters, 20, 175. https://doi.org/10.3892/ol.2020.12036
MLA
Zhao, Z., Zhou, Y., Wang, J., Zhang, T., Li, J., Zhang, B., Li, Q., Deng, S."The value of <sup>18</sup>F‑FDG PET/CT in the prediction of clinical outcomes of patients with acute leukemia treated with allogeneic hematopoietic stem cell transplantation". Oncology Letters 20.5 (2020): 175.
Chicago
Zhao, Z., Zhou, Y., Wang, J., Zhang, T., Li, J., Zhang, B., Li, Q., Deng, S."The value of <sup>18</sup>F‑FDG PET/CT in the prediction of clinical outcomes of patients with acute leukemia treated with allogeneic hematopoietic stem cell transplantation". Oncology Letters 20, no. 5 (2020): 175. https://doi.org/10.3892/ol.2020.12036
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao Z, Zhou Y, Wang J, Zhang T, Li J, Zhang B, Li Q and Deng S: The value of <sup>18</sup>F‑FDG PET/CT in the prediction of clinical outcomes of patients with acute leukemia treated with allogeneic hematopoietic stem cell transplantation. Oncol Lett 20: 175, 2020.
APA
Zhao, Z., Zhou, Y., Wang, J., Zhang, T., Li, J., Zhang, B. ... Deng, S. (2020). The value of <sup>18</sup>F‑FDG PET/CT in the prediction of clinical outcomes of patients with acute leukemia treated with allogeneic hematopoietic stem cell transplantation. Oncology Letters, 20, 175. https://doi.org/10.3892/ol.2020.12036
MLA
Zhao, Z., Zhou, Y., Wang, J., Zhang, T., Li, J., Zhang, B., Li, Q., Deng, S."The value of <sup>18</sup>F‑FDG PET/CT in the prediction of clinical outcomes of patients with acute leukemia treated with allogeneic hematopoietic stem cell transplantation". Oncology Letters 20.5 (2020): 175.
Chicago
Zhao, Z., Zhou, Y., Wang, J., Zhang, T., Li, J., Zhang, B., Li, Q., Deng, S."The value of <sup>18</sup>F‑FDG PET/CT in the prediction of clinical outcomes of patients with acute leukemia treated with allogeneic hematopoietic stem cell transplantation". Oncology Letters 20, no. 5 (2020): 175. https://doi.org/10.3892/ol.2020.12036
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