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Association between excessive chronic iodine exposure and the occurrence of papillary thyroid carcinoma

  • Authors:
    • Fengyan Huang
    • Wei Cong
    • Juan Xiao
    • Yong Zhou
    • Maosong Gong
    • Jingfu Sun
    • Liqun  Shan
    • Qiang Xiao
    • Lihua Wang
    • Jianing Liu
    • Zhigang Yu
    • Hongying Jia
  • View Affiliations / Copyright

    Affiliations: Department of Epidemiology and Health Statistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, P.R. China, Department of Thyroid Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250033, P.R. China
    Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 189
    |
    Published online on: September 3, 2020
       https://doi.org/10.3892/ol.2020.12051
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Abstract

The aim of the present study was to elucidate the association between excessive chronic iodine exposure and the risk of developing papillary thyroid carcinoma (PTC). The demographic information and pathological characteristics of patients with thyroid nodules were retrieved from medical records at The Second Hospital of Shandong University. A fasting urine specimen was collected, and creatinine and urinary iodine concentration (UIC) were determined. The water iodine data from the domicile districts of these patients were collated from published reports. The results revealed that almost half of the patients with PTC (44.3%) also exhibited a high UIC (≥300 µg/l). Multivariate analysis revealed that the adjusted odds ratio for high UIC was 3.987 (95% CI: 1.355‑11.736) and the adjusted area under the receiver operating characteristic curve was 0.776 (95% CI: 0.687‑0.864), which was associated with PTC risk in patients with thyroid nodules. Integrated ecological assessment of chronic iodine exposures demonstrated that >80% (81.4%) of the patients with PTC who also exhibited a high UIC were from historically non‑iodine‑deficient regions, and 66.7% of patients with PTC who resided in historically iodine‑excessive regions were characterized by high UICs. Importantly, a high UIC was significantly associated with capsular invasion and extrathyroid metastasis (P<0.05). Moreover, self‑matching results indicated that, in patients with PTC, there were no significant differences in UIC grading between the pre‑ and postoperative specimens. In conclusion, excessive chronic iodine exposure is significantly associated with the risk of PTC, which contributes to increased capsular invasion and extrathyroid metastases. However, further research is required to validate these findings and to elucidate the potential molecular mechanisms involved.
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Copy and paste a formatted citation
Spandidos Publications style
Huang F, Cong W, Xiao J, Zhou Y, Gong M, Sun J, Shan L, Xiao Q, Wang L, Liu J, Liu J, et al: Association between excessive chronic iodine exposure and the occurrence of papillary thyroid carcinoma. Oncol Lett 20: 189, 2020.
APA
Huang, F., Cong, W., Xiao, J., Zhou, Y., Gong, M., Sun, J. ... Jia, H. (2020). Association between excessive chronic iodine exposure and the occurrence of papillary thyroid carcinoma. Oncology Letters, 20, 189. https://doi.org/10.3892/ol.2020.12051
MLA
Huang, F., Cong, W., Xiao, J., Zhou, Y., Gong, M., Sun, J., Shan, L., Xiao, Q., Wang, L., Liu, J., Yu, Z., Jia, H."Association between excessive chronic iodine exposure and the occurrence of papillary thyroid carcinoma". Oncology Letters 20.5 (2020): 189.
Chicago
Huang, F., Cong, W., Xiao, J., Zhou, Y., Gong, M., Sun, J., Shan, L., Xiao, Q., Wang, L., Liu, J., Yu, Z., Jia, H."Association between excessive chronic iodine exposure and the occurrence of papillary thyroid carcinoma". Oncology Letters 20, no. 5 (2020): 189. https://doi.org/10.3892/ol.2020.12051
Copy and paste a formatted citation
x
Spandidos Publications style
Huang F, Cong W, Xiao J, Zhou Y, Gong M, Sun J, Shan L, Xiao Q, Wang L, Liu J, Liu J, et al: Association between excessive chronic iodine exposure and the occurrence of papillary thyroid carcinoma. Oncol Lett 20: 189, 2020.
APA
Huang, F., Cong, W., Xiao, J., Zhou, Y., Gong, M., Sun, J. ... Jia, H. (2020). Association between excessive chronic iodine exposure and the occurrence of papillary thyroid carcinoma. Oncology Letters, 20, 189. https://doi.org/10.3892/ol.2020.12051
MLA
Huang, F., Cong, W., Xiao, J., Zhou, Y., Gong, M., Sun, J., Shan, L., Xiao, Q., Wang, L., Liu, J., Yu, Z., Jia, H."Association between excessive chronic iodine exposure and the occurrence of papillary thyroid carcinoma". Oncology Letters 20.5 (2020): 189.
Chicago
Huang, F., Cong, W., Xiao, J., Zhou, Y., Gong, M., Sun, J., Shan, L., Xiao, Q., Wang, L., Liu, J., Yu, Z., Jia, H."Association between excessive chronic iodine exposure and the occurrence of papillary thyroid carcinoma". Oncology Letters 20, no. 5 (2020): 189. https://doi.org/10.3892/ol.2020.12051
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