Open Access

High glypican‑1 expression is a prognostic factor for predicting a poor clinical prognosis in patients with hepatocellular carcinoma

  • Authors:
    • Guoyong Chen
    • Hao Wu
    • Lei Zhang
    • Sidong Wei
  • View Affiliations

  • Published online on: September 4, 2020     https://doi.org/10.3892/ol.2020.12058
  • Article Number: 197
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Hepatocellular carcinoma (HCC) has a high mortality rate, which imposes a huge burden on patients and society. Glypican‑1 (GPC1) is considered to be an ideal diagnostic marker. The present study aimed to investigate GPC1 expression in HCC, its association with clinicopathological factors and its prognostic significance in HCC progression. Reverse transcription‑quantitative PCR, western blotting and immunohistochemical staining were used to investigate GPC1 expression in 175 HCC and paired normal tissues, and in HCC and normal cells. Serolo2gical levels of GPC1 were examined via enzyme‑linked immunosorbent assay in patients with HCC. Kaplan‑Meier survival analysis and Cox regression analysis were used to assess the prognostic significance of GPC1. The present results suggested that GPC1 expression was upregulated in HCC tissues, especially in metastatic HCC. Similar results were observed in HCC cell lines. Serum GPC1 was higher in patients with HCC than in healthy controls (HCs). Patients with high GPC1 expression had shorter recurrence‑free survival (RFS) and disease‑specific survival (DSS) times compared with those with low GPC1 expression. In addition, high GPC1 expression was significantly associated with tumor size and Tumor‑Node‑Metastasis (TNM) stage (P<0.05). Furthermore, tumor size, TNM stage and GPC1 expression were independent predictive factors for RFS and DSS in patients with HCC. In conclusion, the present results revealed that high GPC1 expression was closely associated with a poor prognosis in patients with HCC and that it may therefore be used as a potential target for accurate diagnosis and treatment of HCC.
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November-2020
Volume 20 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Chen G, Wu H, Zhang L and Wei S: High glypican‑1 expression is a prognostic factor for predicting a poor clinical prognosis in patients with hepatocellular carcinoma. Oncol Lett 20: 197, 2020
APA
Chen, G., Wu, H., Zhang, L., & Wei, S. (2020). High glypican‑1 expression is a prognostic factor for predicting a poor clinical prognosis in patients with hepatocellular carcinoma. Oncology Letters, 20, 197. https://doi.org/10.3892/ol.2020.12058
MLA
Chen, G., Wu, H., Zhang, L., Wei, S."High glypican‑1 expression is a prognostic factor for predicting a poor clinical prognosis in patients with hepatocellular carcinoma". Oncology Letters 20.5 (2020): 197.
Chicago
Chen, G., Wu, H., Zhang, L., Wei, S."High glypican‑1 expression is a prognostic factor for predicting a poor clinical prognosis in patients with hepatocellular carcinoma". Oncology Letters 20, no. 5 (2020): 197. https://doi.org/10.3892/ol.2020.12058