search button
Open Access

Combination of preoperative fibrinogen concentration and neutrophil‑to‑lymphocyte ratio for prediction of the prognosis of patients with resectable breast cancer

  • Authors:
    • Xi Cao
    • Yidong Zhou
    • Feng Mao
    • Yan Lin
    • Qiang Sun

  • View Affiliations

  • Published online on: September 4, 2020     https://doi.org/10.3892/ol.2020.12061
  • Article Number: 200

  • Copyright: © Cao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Previous studies have demonstrated that the combination of high preoperative fibrinogen levels and high neutrophil‑to‑lymphocyte ratio (NLR) is associated with poor outcomes in various types of cancer. The present study assessed the prognostic value of a scoring system based on the combination of fibrinogen concentration and neutrophil‑to‑lymphocyte ratio (F‑NLR) in untreated patients with resectable breast cancer (BC). The present study retrospectively analyzed 906 patients who received surgery for resectable BC. Univariate and multivariate analyses were performed to explore the association between the F‑NLR score and survival status. The cut‑off values for fibrinogen and NLR determined via receiver operating characteristic curve analysis were 3.21 g/l and 2.20, respectively. On the basis of these cut‑off values, the whole cohort was divided into three groups according to their F‑NLR score: Score 2, fibrinogen ≥3.21 g/l and NLR ≥2.20; score 1, fibrinogen ≥3.21 g/l or NLR ≥2.20; and score 0, fibrinogen <3.21 g/l and NLR <2.20. The F‑NLR score was significantly associated with age (≤50 years vs. >50 years; P<0.001), tumor size (≤2 cm vs. >2 cm; P=0.001), lymph node status (P=0.029), TNM stage (I vs. II vs. III; P=0.002) and lymphovascular invasion (P<0.001). The 5‑year disease‑free survival (DFS) rates in the patients with F‑NLR scores of 0, 1 and 2 were 95.7, 87.5 and 74.0%, respectively (P<0.001), and the 5‑year overall survival (OS) rates were 97.8, 90.9 and 79.9%, respectively (P<0.001). Furthermore, multivariate analysis demonstrated that the F‑NLR score independently predicted DFS [hazard ratio (HR), 2.279; 95% CI, 1.758‑2.954; P<0.001] and OS (HR, 2.414; 95% CI, 1.738‑3.353; P<0.001). In conclusion, the preoperative F‑NLR score was an independent prognostic indicator for untreated patients with resectable BC.
View Figures
View References

Related Articles

Journal Cover

November-2020
Volume 20 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

  • Journal Metrics
  • Impact Factor: 2.9
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 6.3
  • CiteScore Rank: Q2: #119/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.725
  • SCImago Journal Rank (SJR): 0.639
International Symposium on Molecular Medicine Conference Banner
The Cancer Story
World Congress on Advances in Oncology and International Symposium on Molecular Medicine Conference Banner
World Academy Of Sciences Banner
Heyday Road Banner

0

Copy and paste a formatted citation
x
Spandidos Publications style
Cao X, Zhou Y, Mao F, Lin Y and Sun Q: Combination of preoperative fibrinogen concentration and neutrophil‑to‑lymphocyte ratio for prediction of the prognosis of patients with resectable breast cancer. Oncol Lett 20: 200, 2020
APA
Cao, X., Zhou, Y., Mao, F., Lin, Y., & Sun, Q. (2020). Combination of preoperative fibrinogen concentration and neutrophil‑to‑lymphocyte ratio for prediction of the prognosis of patients with resectable breast cancer. Oncology Letters, 20, 200. https://doi.org/10.3892/ol.2020.12061
MLA
Cao, X., Zhou, Y., Mao, F., Lin, Y., Sun, Q."Combination of preoperative fibrinogen concentration and neutrophil‑to‑lymphocyte ratio for prediction of the prognosis of patients with resectable breast cancer". Oncology Letters 20.5 (2020): 200.
Chicago
Cao, X., Zhou, Y., Mao, F., Lin, Y., Sun, Q."Combination of preoperative fibrinogen concentration and neutrophil‑to‑lymphocyte ratio for prediction of the prognosis of patients with resectable breast cancer". Oncology Letters 20, no. 5 (2020): 200. https://doi.org/10.3892/ol.2020.12061