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ERCC overexpression associated with a poor response of cT4b colorectal cancer with FOLFOX‑based neoadjuvant concurrent chemoradiation

  • Authors:
    • Ming-Yii Huang
    • Hsin-Hua Lee
    • Ching-Wen Huang
    • Chun-Ming  Huang
    • Cheng-Jen Ma
    • Tzu-Chieh Yin
    • Hsiang-Lin Tsai
    • Chee-Yin  Chai
    • Yi-Ting Chen
    • Jaw-Yuan Wang
  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C., Division of Colorectal Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C., Department of Pathology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, R.O.C., Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C.
    Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 212
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    Published online on: September 8, 2020
       https://doi.org/10.3892/ol.2020.12075
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Abstract

Colorectal cancer (CRC) of the clinical tumor stage T4b (cT4b) refers to advanced tumors with direct invasion of adjacent structures and the tumors are considered unresectable. Despite advancements in aggressive surgery and combination chemotherapy, the prognosis of cT4b CRC remains poor. Optimizing the therapeutic sequence administered to patients with cT4b CRC to improve clinical outcomes is crucial. In the present study, patients with unresectable cT4b and nodal stage N1‑2 CRC were investigated at a single institution. A total of 20 consecutive patients were treated with pre‑operative concurrent chemoradiation by using 5‑fluorouracil/leucovorin/oxaliplatin (FOLFOX) since February 2015 and were regularly followed up until March 2020. Due to their poor response to concurrent chemoradiation (CCRT) with FOLFOX, the chemotherapy regimen was changed to irinotecan plus 5‑fluorouracil/leucovorin (FOLFIRI) as the second‑line neoadjuvant treatment. Genetic alterations, such as microsatellite instability (MSI), were documented, and the expression levels of excision repair cross‑complementing group 1 (ERCC1) and ERCC2 were examined. Of the 20 patients, the tumors of 14 patients (70%) became resectable after FOLFIRI administration. The median duration between the last date of radiotherapy and surgery was 32.7 weeks (range, 10.1‑59.3 weeks). Of note, 4 of the 14 patients with resectable tumors (28.6%) achieved a pathologic complete response. The median overall survival and progression‑free survival were 27.5 months (range, 12‑39 months) and 27.5 months (range, 8‑39 months), respectively. The cancerous specimens of all of the patients (100%) exhibited ERCC2 overexpression and 18 specimens (90%) had ERCC1 overexpression. Only one tumor (5%) exhibited high MSI. The present study indicated that ERCC overexpression associated with the poor response of FOLFOX‑based CCRT and FOLFIRI after FOLFOX‑based CCRT failure may have a potential role in conversion to resectable tumors by neoadjuvant treatment in cT4b CRC. However, a further prospective study with more patients is required to improve the precision of the conclusions.
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1 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Douaiher J, Ravipati A, Grams B, Chowdhury S, Alatise O and Are C: Colorectal cancer-global burden, trends, and geographical variations. J Surg Oncol. 115:619–630. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Torre LA, Islami F, Siegel RL, Ward EM and Jemal A: Global cancer in women: Burden and trends. Cancer Epidemiol Biomarkers Prev. 26:444–457. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2019. CA Cancer J Clin. 69:7–34. 2019. View Article : Google Scholar : PubMed/NCBI

5 

Ministry of Health Welfare: The cause of death in Taiwan in 2016. http://www.mohw.gov.tw/cp-16-33598-1.htmlAugust 25–2017

6 

National Comprehensive Cancer Network: Rectal Cancer. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines). version 2. 2019.

7 

Hawkins AT, Ford MM, Geiger TM, Hopkins MB, Kachnic LA, Muldoon RL and Glasgow SC: Neoadjuvant radiation for clinical T4 colon cancer: A potential improvement to overall survival. Surgery. 165:469–475. 2019. View Article : Google Scholar : PubMed/NCBI

8 

Edge SB, Byrd DR, Compton CC, Fritz AG, Greene FL and Trotti A: AJCC Cancer Staging Manual. 7th. New York; Springer-Verlag: 2010

9 

Ma SC, Zhao Y, Zhang T, Ling XL and Zhao D: Association between the ERCC1 rs11615 polymorphism and clinical outcomes of oxaliplatin-based chemotherapies in gastrointestinal cancer: A meta-analysis. Onco Targets Ther. 8:641–648. 2015.PubMed/NCBI

10 

Huang MY, Tsai HL, Lin CH, Huang CW, Ma CJ, Huang CM, Chai CY and Wang JY: Predictive value of ERCC1, ERCC2, and XRCC1 overexpression for stage III colorectal cancer patients receiving FOLFOX-4 adjuvant chemotherapy. J Surg Oncol. 108:457–464. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Amshel C, Avital S, Miller A, Sands L, Marchetti F and Hellinger M: T4 rectal cancer: Analysis of patient outcome after surgical excision. Am Surg. 71:901–903; discussion 904. 2005.PubMed/NCBI

12 

Diaconescu M, Burada F, Mirea CS, Moraru E, Ciorbagiu MC, Obleaga CV and Vilcea ID: T4 Colon cancer-current management. Curr Health Sci J. 44:5–13. 2018.PubMed/NCBI

13 

Gao P, Song YX, Wang ZN, Xu YY, Tong LL, Sun JX, Yu M and Xu HM: Is the prediction of prognosis not improved by the seventh edition of the TNM classification for colorectal cancer? Analysis of the surveillance, epidemiology, and end results (SEER) database. BMC Cancer. 13:1232013. View Article : Google Scholar : PubMed/NCBI

14 

Gunderson LL, Jessup JM, Sargent DJ, Greene FL and Stewart AK: Revised TN categorization for colon cancer based on national survival outcomes data. J Clin Oncol. 28:264–271. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Huang C-M, Huang M-Y, Ma C-J, Yeh Y-S, Tsai H-L, Huang C-W, Huang C-J and Wang J-Y: Neoadjuvant FOLFOX chemotherapy combined with radiotherapy followed by radical resection in patients with locally advanced colon cancer. Radiat Oncol. 12:482017. View Article : Google Scholar : PubMed/NCBI

16 

Lu CY, Huang CW, Wu IC, Tsai HL, Ma CJ, Yeh YS, Chang SF, Huang ML and Wang JY: Clinical implication of UGT1A1 promoter polymorphism for irinotecan dose escalation in metastatic colorectal cancer patients treated with bevacizumab combined with FOLFIRI in the first-line setting. Transl Oncol. 8:474–479. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Eisenhauer EA, Therasse P, Bogaerts J, Schwartz LH, Sargent D, Ford R, Dancey J, Arbuck S, Gwyther S, Mooney M, et al: New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1). Eur J Cancer. 45:228–247. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Tirkes T, Hollar MA, Tann M, Kohli MD, Akisik F and Sandrasegaran K: Response criteria in oncologic imaging: Review of traditional and new criteria. Radiographics. 33:1323–1341. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Huang MY, Huang JJ, Huang CM, Lin CH, Tsai HL, Huang CW, Chai CY, Lin CY and Wang JY: Relationship between expression of proteins ERCC1, ERCC2, and XRCC1 and clinical outcomes in patients with rectal cancer treated with FOLFOX-based preoperative chemoradiotherapy. World J Surg. 41:2884–2897. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Chang H, Yu X, Xiao WW, Wang QX, Zhou WH, Zeng ZF, Ding PR, Li LR and Gao YH: Neoadjuvant chemoradiotherapy followed by surgery in patients with unresectable locally advanced colon cancer: A prospective observational study. Onco Targets Ther. 11:409–418. 2018. View Article : Google Scholar : PubMed/NCBI

21 

Li L and Ma BB: Colorectal cancer in Chinese patients: Current and emerging treatment options. Onco Targets Ther. 7:1817–1828. 2014.PubMed/NCBI

22 

National Comprehensive Cancer Network: Colon cancer. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines). version 2. 2019.

23 

Gezen C, Kement M, Altuntas YE, Okkabaz N, Seker M, Vural S, Gumus M and Oncel M: Results after multivisceral resections of locally advanced colorectal cancers: An analysis on clinical and pathological t4 tumors. World J Surg Oncol. 10:392012. View Article : Google Scholar : PubMed/NCBI

24 

Lehnert T, Methner M, Pollok A, Schaible A, Hinz U and Herfarth C: Multivisceral resection for locally advanced primary colon and rectal cancer: An analysis of prognostic factors in 201 patients. Ann Surg. 235:217–225. 2002. View Article : Google Scholar : PubMed/NCBI

25 

Foxtrot Collaborative Group, : Feasibility of preoperative chemotherapy for locally advanced, operable colon cancer: The pilot phase of a randomised controlled trial. Lancet Oncol. 13:1152–1160. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Dehal A, Graff-Baker AN, Vuong B, Fischer T, Klempner SJ, Chang SC, Grunkemeier GL, Bilchik AJ and Goldfarb M: Neoadjuvant chemotherapy improves survival in patients with clinical T4b colon cancer. J Gastrointest Surg. 22:242–249. 2018. View Article : Google Scholar : PubMed/NCBI

27 

Grossmann I, Klaase JM, Avenarius JK, de Hingh IH, Mastboom WJ and Wiggers T: The strengths and limitations of routine staging before treatment with abdominal CT in colorectal cancer. BMC Cancer. 11:4332011. View Article : Google Scholar : PubMed/NCBI

28 

Takano S, Kato J, Yamamoto H, Shiode J, Nasu J, Kawamoto H, Okada H and Shiratori Y: Identification of risk factors for lymph node metastasis of colorectal cancer. Hepatogastroenterology. 54:746–750. 2007.PubMed/NCBI

29 

Larkin JO and O'Connell PR: Multivisceral resection for T4 or recurrent colorectal cancer. Dig Dis. 30 (Suppl 2):S96–S101. 2012. View Article : Google Scholar

30 

Olaussen KA, Dunant A, Fouret P, Brambilla E, André F, Haddad V, Taranchon E, Filipits M, Pirker R, Popper HH, et al: DNA repair by ERCC1 in non-small-cell lung cancer and cisplatin-based adjuvant chemotherapy. N Engl J Med. 355:983–991. 2006. View Article : Google Scholar : PubMed/NCBI

31 

Grimminger PP, Shi M, Barrett C, Lebwohl D, Danenberg KD, Brabender J, Vigen CL, Danenberg PV, Winder T and Lenz HJ: TS and ERCC-1 mRNA expressions and clinical outcome in patients with metastatic colon cancer in CONFIRM-1 and −2 clinical trials. Pharmacogenomics J. 12:404–411. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Lee SM, Falzon M, Blackhall F, Spicer J, Nicolson M, Chaudhuri A, Middleton G, Ahmed S, Hicks J, Crosse B, et al: Randomized prospective biomarker trial of ERCC1 for comparing platinum and nonplatinum therapy in advanced non-small-cell lung cancer: ERCC1 trial (ET). J Clin Oncol. 35:402–411. 2017. View Article : Google Scholar : PubMed/NCBI

33 

Raymond E, Faivre S, Chaney S, Woynarowski J and Cvitkovic E: Cellular and molecular pharmacology of oxaliplatin. Mol Cancer Ther. 1:227–235. 2002.PubMed/NCBI

34 

Rosell R, Mendez P, Isla D and Taron M: Platinum resistance related to a functional NER pathway. J Thorac Oncol. 2:1063–1066. 2007. View Article : Google Scholar : PubMed/NCBI

35 

Gossage L and Madhusudan S: Current status of excision repair cross complementing-group 1 (ERCC1) in cancer. Cancer Treat Rev. 33:565–577. 2007. View Article : Google Scholar : PubMed/NCBI

36 

Noda E, Maeda K, Inoue T, Fukunaga S, Nagahara H, Shibutani M, Amano R, Nakata B, Tanaka H, Muguruma K, et al: Predictive value of expression of ERCC 1 and GST-p for 5-fluorouracil/oxaliplatin chemotherapy in advanced colorectal cancer. Hepatogastroenterology. 59:130–133. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Shirota Y, Stoehlmacher J, Brabender J, Xiong YP, Uetake H, Danenberg KD, Groshen S, Tsao-Wei DD, Danenberg PV and Lenz HJ: ERCC1 and thymidylate synthase mRNA levels predict survival for colorectal cancer patients receiving combination oxaliplatin and fluorouracil chemotherapy. J Clin Oncol. 19:4298–4304. 2001. View Article : Google Scholar : PubMed/NCBI

38 

Chang PM, Tzeng CH, Chen PM, Lin JK, Lin TC, Chen WS, Jiang JK, Wang HS and Wang WS: ERCC1 codon 118 C->T polymorphism associated with ERCC1 expression and outcome of FOLFOX-4 treatment in Asian patients with metastatic colorectal carcinoma. Cancer Sci. 100:278–283. 2009. View Article : Google Scholar : PubMed/NCBI

39 

Basso M, Strippoli A, Orlandi A, Martini M, Calegari MA, Schinzari G, Di Salvatore M, Cenci T, Cassano A, Larocca LM and Barone C: KRAS mutational status affects oxaliplatin-based chemotherapy independently from basal mRNA ERCC-1 expression in metastatic colorectal cancer patients. Br J Cancer. 108:115–120. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Ishibashi K, Okada N, Ishiguro T, Kuwabara K, Ohsawa T, Yokoyama M, Kumamoto K, Haga N, Mori T, Yamada H, et al: The expression of thymidylate synthase (TS) and excision repair complementing-1 (ERCC-1) protein in patients with unresectable colorectal cancer treated with mFOLFOX6 therapy. Gan To Kagaku Ryoho. 37:2532–2535. 2010.(In Japanese). PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Huang M, Lee H, Huang C, Huang C, Ma C, Yin T, Tsai H, Chai C, Chen Y, Wang J, Wang J, et al: ERCC overexpression associated with a poor response of cT4b colorectal cancer with FOLFOX‑based neoadjuvant concurrent chemoradiation. Oncol Lett 20: 212, 2020.
APA
Huang, M., Lee, H., Huang, C., Huang, C., Ma, C., Yin, T. ... Wang, J. (2020). ERCC overexpression associated with a poor response of cT4b colorectal cancer with FOLFOX‑based neoadjuvant concurrent chemoradiation. Oncology Letters, 20, 212. https://doi.org/10.3892/ol.2020.12075
MLA
Huang, M., Lee, H., Huang, C., Huang, C., Ma, C., Yin, T., Tsai, H., Chai, C., Chen, Y., Wang, J."ERCC overexpression associated with a poor response of cT4b colorectal cancer with FOLFOX‑based neoadjuvant concurrent chemoradiation". Oncology Letters 20.5 (2020): 212.
Chicago
Huang, M., Lee, H., Huang, C., Huang, C., Ma, C., Yin, T., Tsai, H., Chai, C., Chen, Y., Wang, J."ERCC overexpression associated with a poor response of cT4b colorectal cancer with FOLFOX‑based neoadjuvant concurrent chemoradiation". Oncology Letters 20, no. 5 (2020): 212. https://doi.org/10.3892/ol.2020.12075
Copy and paste a formatted citation
x
Spandidos Publications style
Huang M, Lee H, Huang C, Huang C, Ma C, Yin T, Tsai H, Chai C, Chen Y, Wang J, Wang J, et al: ERCC overexpression associated with a poor response of cT4b colorectal cancer with FOLFOX‑based neoadjuvant concurrent chemoradiation. Oncol Lett 20: 212, 2020.
APA
Huang, M., Lee, H., Huang, C., Huang, C., Ma, C., Yin, T. ... Wang, J. (2020). ERCC overexpression associated with a poor response of cT4b colorectal cancer with FOLFOX‑based neoadjuvant concurrent chemoradiation. Oncology Letters, 20, 212. https://doi.org/10.3892/ol.2020.12075
MLA
Huang, M., Lee, H., Huang, C., Huang, C., Ma, C., Yin, T., Tsai, H., Chai, C., Chen, Y., Wang, J."ERCC overexpression associated with a poor response of cT4b colorectal cancer with FOLFOX‑based neoadjuvant concurrent chemoradiation". Oncology Letters 20.5 (2020): 212.
Chicago
Huang, M., Lee, H., Huang, C., Huang, C., Ma, C., Yin, T., Tsai, H., Chai, C., Chen, Y., Wang, J."ERCC overexpression associated with a poor response of cT4b colorectal cancer with FOLFOX‑based neoadjuvant concurrent chemoradiation". Oncology Letters 20, no. 5 (2020): 212. https://doi.org/10.3892/ol.2020.12075
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