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Article Open Access

Analysis of key genes and pathways in breast ductal carcinoma in situ

  • Authors:
    • Min Wu
    • Hongmei Zhao
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Beijing Youan Hospital, Capital Medical University, Beijing 100069, P.R. China, Department of General Surgery, Peking University Third Hospital, Beijing 100191, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 217
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    Published online on: September 9, 2020
       https://doi.org/10.3892/ol.2020.12080
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Abstract

Breast cancer (BC) remains the most common cancer in females. Therefore, the present study aimed to identify key genes involved in the carcinogenesis of BC and to explore their prognostic values by integrating bioinformatics tools. The gene expression profiles of 46 ductal carcinoma in situ (DCIS) and three normal breast tissues from the GSE59248 dataset were downloaded. Differentially expressed genes (DEGs) were subsequently identified using the online tool GEO2R and a functional enrichment analysis was performed. In addition, a protein‑protein interaction (PPI) network was constructed and the top eight hub genes were identified. The prognostic values of the hub genes were further investigated. A total of 316 DEGs, including 32 upregulated and 284 downregulated genes, were identified. Furthermore, eight hub genes, including lipase E hormone sensitive type, patatin like phospholipase domain containing 2, adiponectin C1Q and collagen domain containing (ADIPOQ), peroxisome proliferator activated receptor γ (PPARG), fatty acid binding protein 4 (FABP4), diacylglycerol O‑acyltransferase 2, lipoprotein lipase (LPL) and leptin (LEP), were identified from the PPI network. The downregulated expression of ADIPOQ, PPARG, FABP4, LPL and LEP was significantly associated with poor overall survival in patients with DCIS. Therefore, these genes may serve as potential biomarkers for prognosis prediction. However, further investigation is required to validate the results obtained in the present study.
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View References

1 

Smith RA, Andrews KS, Brooks D, Fedewa SA, Manassaram-Baptiste D, Saslow D, Brawley OW and Wender RC: Cancer screening in the United States, 2018: A review of current american cancer society guidelines and current issues in cancer screening. CA Cancer J Clin. 68:297–316. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Kurian AW, Lichtensztajn DY, Keegan TH, Nelson DO, Clarke CA and Gomez SL: Use of and mortality after bilateral mastectomy compared with other surgical treatments for breast cancer in California, 1998–2011. JAMA. 312:902–914. 2014. View Article : Google Scholar : PubMed/NCBI

4 

van der Veldt AA and Smit EF: Bevacizumab in neoadjuvant treatment for breast cancer. N Engl J Med. 366:1637–1640. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Leal NF, Carrara HH, Vieira KF and Ferreira CH: Physiotherapy treatments for breast cancer-related lymphedema: A literature review. Rev Lat Am Enfermagem. 17:730–736. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Yeong J, Thike AA, Tan PH and Iqbal J: Identifying progression predictors of breast ductal carcinoma in situ. J Clin Pathol. 70:102–108. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Ernster VL, Ballard-Barbash R, Barlow WE, Zheng Y, Weaver DL, Cutter G, Yankaskas BC, Rosenberg R, Carney PA, Kerlikowske K, et al: Detection of ductal carcinoma in situ in women undergoing screening mammography. J Natl Cancer Inst. 94:1546–1554. 2002. View Article : Google Scholar : PubMed/NCBI

8 

Sanders ME, Schuyler PA, Dupont WD and Page DL: The natural history of low-grade ductal carcinoma in situ of the breast in women treated by biopsy only revealed over 30 years of long-term follow-up. Cancer. 103:2481–2484. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Abba MC, Drake JA, Hawkins KA, Hu Y, Sun H, Notcovich C, Gaddis S, Sahin A, Baggerly K and Aldaz CM: Transcriptomic changes in human breast cancer progression as determined by serial analysis of gene expression. Breast Cancer Res. 6:R499–R513. 2004. View Article : Google Scholar : PubMed/NCBI

10 

Castro NP, Osório CA, Torres C, Bastos EP, Mourão-Neto M, Soares FA, Brentani HP and Carraro DM: Evidence that molecular changes in cells occur before morphological alterations during the progression of breast ductal carcinoma. Breast Cancer Res. 10:R872008. View Article : Google Scholar : PubMed/NCBI

11 

Schuetz CS, Michael B, Clare SE, Nieselt K, Sotlar K, Walter M, Fehm T, Solomayer E, Riess O, Wallwiener D, et al: Progression-specific genes identified by expression profiling of matched ductal carcinomas in situ and invasive breast tumors, combining laser capture microdissection and oligonucleotide microarray analysis. Cancer Res. 66:5278–5286. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Choi Y, Lee HJ, Jang MH, Gwak JM, Lee KS, Kim EJ, Kim HJ, Lee HE and Park SY: Epithelial-mesenchymal transition increases during the progression of in situ to invasive basal-like breast cancer. Hum Pathol. 44:2581–2589. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Shah S, Brock EJ, Jackson RM, Ji K, Boerner JL, Sloane BF and Mattingly RR: Downregulation of Rap1Gap: A switch from DCIS to invasive breast carcinoma via ERK/MAPK activation. Neoplasia. 20:951–963. 2018. View Article : Google Scholar : PubMed/NCBI

14 

Sakr RA, Weigelt B, Chandarlapaty S, Andrade VP, Guerini-Rocco E, Giri D, Ng CK, Cowell CF, Rosen N, Reis-Filho JS and King TA: PI3K pathway activation in high-grade ductal carcinoma in situ-implications for progression to invasive breast carcinoma. Clin Cancer Res. 20:2326–2337. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Hannemann J, Velds A, Halfwerk JB, Kreike B, Peterse JL and van de Vijver MJ: Classification of ductal carcinoma in situ by gene expression profiling. Breast Cancer Res. 8:R612006. View Article : Google Scholar : PubMed/NCBI

16 

Mi H, Huang X, Muruganujan A, Tang H, Mills C, Kang D and Thomas PD: PANTHER version 11: Expanded annotation data from gene ontology and reactome pathways, and data analysis tool enhancements. Nucleic Acids Res. 45:D183–D189. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Huang da W, Sherman BT and Lempicki RA: Bioinformatics enrichment tools: Paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res. 37:1–13. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Szklarczyk D, Morris JH, Cook H, Kuhn M, Wyder S, Simonovic M, Santos A, Doncheva NT, Roth A, Bork P, et al: The STRING database in 2017: Quality-controlled protein-protein association networks, made broadly accessible. Nucleic Acids Res. 45:D362–D368. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Lesurf R, Aure MR, Mørk HH, Vitelli V; Oslo Breast Cancer Research Consortium (OSBREAC), ; Lundgren S, Børresen-Dale AL, Kristensen V, Wärnberg F, Hallett M and Sørlie T: Molecular features of subtype-specific progression from ductal carcinoma in situ to invasive breast cancer. Cell Rep. 16:1166–1179. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Green GH and Diggle PJ: On the operational characteristics of the benjamini and hochberg false discovery rate procedure. Stat Appl Genet Mol Biol. 6:Article272007. View Article : Google Scholar : PubMed/NCBI

21 

Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B and Ideker T: Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res. 13:2498–2504. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Chin CH, Chen SH, Wu HH, Ho CW, Ko MT and Lin CY: CytoHubba: Identifying hub objects and sub-networks from complex interactome. BMC Syst Biol. 8 (Suppl 4):S112014. View Article : Google Scholar : PubMed/NCBI

23 

Meghanathan N: Correlation coefficient analysis: Centrality vs. maximal clique size for complex real-world network graphs. 2016. View Article : Google Scholar

24 

Györffy B, Lanczky A, Eklund AC, Denkert C, Budczies J, Li Q and Szallasi Z: An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients. Breast Cancer Res Treat. 123:725–731. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Tan PH: Pathology of ductal carcinoma in situ of the breast: A heterogeneous entity in need of greater understanding. Ann The Acad Med Singap. 30:671–677. 2001.

26 

Gorringe KL and Fox SB: Ductal carcinoma in situ biology, biomarkers, and diagnosis. Front Oncol. 7:2482017. View Article : Google Scholar : PubMed/NCBI

27 

Chung SJ, Nagaraju GP, Nagalingam A, Muniraj N, Kuppusamy P, Walker A, Woo J, Győrffy B, Gabrielson E, Saxena NK and Sharma D: ADIPOQ/adiponectin induces cytotoxic autophagy in breast cancer cells through STK11/LKB1-mediated activation of the AMPK-ULK1 axis. Autophagy. 13:1386–1403. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Divella R, Daniele A, Mazzocca A, Abbate I, Casamassima P, Caliandro C, Ruggeri E, Naglieri E, Sabbà C and De Luca R: ADIPOQ rs266729 G/C gene polymorphism and plasmatic adipocytokines connect metabolic syndrome to colorectal cancer. J Cancer. 8:1000–1008. 2017. View Article : Google Scholar : PubMed/NCBI

29 

Canto P, Granados JB, Feria-Bernal G, Coral-Vázquez RM, García-García E, Tejeda ME, Tapia A, Rojano-Mejía D and Méndez JP: PPARGC1A and ADIPOQ polymorphisms are associated with aggressive prostate cancer in Mexican-Mestizo men with overweight or obesity. Cancer Biomark. 19:297–303. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Delort L, Jardé T, Dubois V, Vasson MP and Caldefie-Chézet F: New insights into anticarcinogenic properties of adiponectin: A potential therapeutic approach in breast cancer? Vitam Horm. 90:397–417. 2012. View Article : Google Scholar : PubMed/NCBI

31 

He W: PPARgamma2 polymorphism and human health. PPAR Res. 2009:8495382009. View Article : Google Scholar : PubMed/NCBI

32 

Crusz SM and Balkwill FR: Inflammation and cancer: Advances and new agents. Nat Rev Clin Oncol. 12:584–596. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Robbins GT and Nie D: PPAR gamma, bioactive lipids, and cancer progression. Front Biosci (Landmark Ed). 17:1816–1834. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Khandekar MJ, Cohen P and Spiegelman BM: Molecular mechanisms of cancer development in obesity. Nat Rev Cancer. 11:886–895. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Zhang S, Jiang J, Chen Z, Wang Y, Tang W, Chen Y and Liu L: Relationship of PPARG, PPARGC1A, and PPARGC1B polymorphisms with susceptibility to hepatocellular carcinoma in an eastern Chinese Han population. Onco Targets Ther. 11:4651–4660. 2018. View Article : Google Scholar : PubMed/NCBI

36 

Xu W, Li Y, Wang X, Chen B, Liu S, Wang Y, Zhao W and Wu J: PPARgamma polymorphisms and cancer risk: A meta-analysis involving 32,138 subjects. Oncol Rep. 24:579–585. 2010.PubMed/NCBI

37 

Gallicchio L, McSorley MA, Newschaffer CJ, Huang HY, Thuita LW, Hoffman SC and Helzlsouer KJ: Body mass, polymorphisms in obesity-related genes, and the risk of developing breast cancer among women with benign breast disease. Cancer Detect Prev. 31:95–101. 2007. View Article : Google Scholar : PubMed/NCBI

38 

Wu MH, Chu CH, Chou YC, Chou WY, Yang T, Hsu GC, Yu CP, Yu JC and Sun CA: Joint effect of peroxisome proliferator-activated receptor gamma genetic polymorphisms and estrogen-related risk factors on breast cancer risk: Results from a case-control study in Taiwan. Breast Cancer Res Treat. 127:777–784. 2011. View Article : Google Scholar : PubMed/NCBI

39 

Furuhashi M: Fatty acid-binding protein 4 in cardiovascular and metabolic diseases. J Atheroscler Thromb. 26:216–232. 2019. View Article : Google Scholar : PubMed/NCBI

40 

Li H, Xiao Y, Tang L, Zhong F, Huang G, Xu JM, Xu AM, Dai RP and Zhou ZG: Adipocyte fatty acid-binding protein promotes palmitate-induced mitochondrial dysfunction and apoptosis in macrophages. Front Immunol. 9:812018. View Article : Google Scholar : PubMed/NCBI

41 

Zhong CQ, Zhang XP, Ma N, Zhang EB, Li JJ, Jiang YB, Gao YZ, Yuan YM, Lan SQ, Xie D and Cheng SQ: FABP4 suppresses proliferation and invasion of hepatocellular carcinoma cells and predicts a poor prognosis for hepatocellular carcinoma. Cancer Med. 7:2629–2640. 2018. View Article : Google Scholar : PubMed/NCBI

42 

Davies BS, Beigneux AP, Fong LG and Young SG: New wrinkles in lipoprotein lipase biology. Curr Opin Lipidol. 23:35–42. 2012. View Article : Google Scholar : PubMed/NCBI

43 

Prieto D and Oppezzo P: Lipoprotein lipase expression in chronic lymphocytic leukemia: New insights into leukemic progression. Molecules. 22:20832017. View Article : Google Scholar

44 

Heintel D, Kienle D, Shehata M, Kröber A, Kroemer E, Schwarzinger I, Mitteregger D, Le T, Gleiss A, Mannhalter C, et al: High expression of lipoprotein lipase in poor risk B-cell chronic lymphocytic leukemia. Leukemia. 19:1216–1223. 2005. View Article : Google Scholar : PubMed/NCBI

45 

Garofalo C and Surmacz E: Leptin and cancer. J Cell Physiol. 207:12–22. 2006. View Article : Google Scholar : PubMed/NCBI

46 

Garofalo C, Sisci D and Surmacz E: Leptin interferes with the effects of the antiestrogen ICI 182,780 in MCF-7 breast cancer cells. Clin Cancer Res. 10:6466–6475. 2004. View Article : Google Scholar : PubMed/NCBI

47 

Hu X, Juneja SC, Maihle NJ and Cleary MP: Leptin-a growth factor in normal and malignant breast cells and for normal mammary gland development. J Natl Cancer Inst. 94:1704–1711. 2002. View Article : Google Scholar : PubMed/NCBI

48 

Okumura M, Yamamoto M, Sakuma H, Kojima T, Maruyama T, Jamali M, Cooper DR and Yasuda K: Leptin and high glucose stimulate cell proliferation in MCF-7 human breast cancer cells: Reciprocal involvement of PKC-alpha and PPAR expression. Biochim Biophys Acta. 1592:107–116. 2002. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wu M and Zhao H: Analysis of key genes and pathways in breast ductal carcinoma <em>in&nbsp;situ</em>. Oncol Lett 20: 217, 2020.
APA
Wu, M., & Zhao, H. (2020). Analysis of key genes and pathways in breast ductal carcinoma <em>in&nbsp;situ</em>. Oncology Letters, 20, 217. https://doi.org/10.3892/ol.2020.12080
MLA
Wu, M., Zhao, H."Analysis of key genes and pathways in breast ductal carcinoma <em>in&nbsp;situ</em>". Oncology Letters 20.5 (2020): 217.
Chicago
Wu, M., Zhao, H."Analysis of key genes and pathways in breast ductal carcinoma <em>in&nbsp;situ</em>". Oncology Letters 20, no. 5 (2020): 217. https://doi.org/10.3892/ol.2020.12080
Copy and paste a formatted citation
x
Spandidos Publications style
Wu M and Zhao H: Analysis of key genes and pathways in breast ductal carcinoma <em>in&nbsp;situ</em>. Oncol Lett 20: 217, 2020.
APA
Wu, M., & Zhao, H. (2020). Analysis of key genes and pathways in breast ductal carcinoma <em>in&nbsp;situ</em>. Oncology Letters, 20, 217. https://doi.org/10.3892/ol.2020.12080
MLA
Wu, M., Zhao, H."Analysis of key genes and pathways in breast ductal carcinoma <em>in&nbsp;situ</em>". Oncology Letters 20.5 (2020): 217.
Chicago
Wu, M., Zhao, H."Analysis of key genes and pathways in breast ductal carcinoma <em>in&nbsp;situ</em>". Oncology Letters 20, no. 5 (2020): 217. https://doi.org/10.3892/ol.2020.12080
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