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Diagnostic value and clinical significance of circulating miR‑650 and CA211 in detecting of gastric carcinoma

  • Authors:
    • Jianlin Chen
    • Lihua Wu
    • Yifan Sun
    • Changjun Luo
    • Xianhua Chen
    • Lihong Wu
    • Junping Ding
    • Gangxi Pan
    • Chaowen Han
    • Zijuan Wu
    • Yongqi Shen

  • View Affiliations

  • Published online on: September 18, 2020     https://doi.org/10.3892/ol.2020.12117
  • Article Number: 254

  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study determined the levels of plasma biomarkers in patients with gastric carcinoma (GC) and investigated their clinical significance and diagnostic value. Between April 2014 and December 2018, 90 patients with GC, 90 patients with precancerous lesions (Pre) and 45 healthy controls (NC) were recruited from the Affiliated Liutie Central Hospital of Guangxi Medical University. Five markers were measured: microRNA‑650 (miRNA‑650; using reverse transcription‑quantitative polymerase chain reaction), and carcinoembryonic antigen (CEA), carbohydrate antigen (CA)125, CA211 and CA50 using electrochemiluminescence. Circulating markers were all upregulated in patients with GC (P<0.05), and CA211 and CA50 were significantly increased in patients with Pre. The miRNA‑650 and CA211 had an area under the curve (AUC) of 0.700 (moderate) and 0.866 (high), respectively, in the diagnosis of GC. Differentiation of GC from Pre yielded an AUC of 0.665 (low) and 0.708 (moderate), respectively. The combination model of miRNA‑650 and CA211 showed an appropriate value of AUC (0.887) to discriminate the GC patients from the healthy subjects with a sensitivity and specificity of 82.5 and 97.7%. Additionally, differentiating GC from Pre yielded an AUC of 0.767 with a sensitivity of 57.1% and a specificity of 95%, respectively. In terms of clinicopathological features, the expression of miRNA‑650 and CA211 in plasma was not associated with the patients' age, sex, Tumor‑Node‑Metastasis stage, or histological type. In conclusion, plasma miRNA‑650 and CA211 is a promising and powerful non‑invasive marker for the detection of GC.
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November-2020
Volume 20 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Chen J, Wu L, Sun Y, Luo C, Chen X, Wu L, Ding J, Pan G, Han C, Wu Z, Wu Z, et al: Diagnostic value and clinical significance of circulating miR‑650 and CA211 in detecting of gastric carcinoma. Oncol Lett 20: 254, 2020
APA
Chen, J., Wu, L., Sun, Y., Luo, C., Chen, X., Wu, L. ... Shen, Y. (2020). Diagnostic value and clinical significance of circulating miR‑650 and CA211 in detecting of gastric carcinoma. Oncology Letters, 20, 254. https://doi.org/10.3892/ol.2020.12117
MLA
Chen, J., Wu, L., Sun, Y., Luo, C., Chen, X., Wu, L., Ding, J., Pan, G., Han, C., Wu, Z., Shen, Y."Diagnostic value and clinical significance of circulating miR‑650 and CA211 in detecting of gastric carcinoma". Oncology Letters 20.5 (2020): 254.
Chicago
Chen, J., Wu, L., Sun, Y., Luo, C., Chen, X., Wu, L., Ding, J., Pan, G., Han, C., Wu, Z., Shen, Y."Diagnostic value and clinical significance of circulating miR‑650 and CA211 in detecting of gastric carcinoma". Oncology Letters 20, no. 5 (2020): 254. https://doi.org/10.3892/ol.2020.12117