Open Access

Prognostic value of immune related genes in lung adenocarcinoma

  • Authors:
    • Han Wang
    • Meng-Sen Wang
    • Ying Wang
    • Yue-Qing Huang
    • Jian-Ping Shi
    • Zhi-Liang Ding
    • Wen-Jie Wang
  • View Affiliations

  • Published online on: September 18, 2020     https://doi.org/10.3892/ol.2020.12122
  • Article Number: 259
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Lung cancer has the highest incidence and mortality rates of all cancers in China. Immune‑related genes and immune infiltrating lymphocytes are involved in tumor growth, and in the past decade, immunotherapy has become increasingly important in the treatment of lung cancer. Using the edgeR package, differentially expressed genes and immune‑related genes (DEIRGs) were identified in patients with lung adenocarcinoma (LUAD). Functional enrichment analysis of DEIRGs was performed using Gene Ontology annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses. Survival‑associated immune‑related genes (IRGs) were selected using univariate Cox regression analysis and the prognostic model was assessed using multivariate Cox regression analysis. Overall, 273 DEIRGs were identified in LUAD, and KEGG pathway analysis of IRGs showed that ‘cytokine‑cytokine receptor interaction’ was the most significantly enriched pathway. Furthermore, six survival associated IRGs were screened to establish a prognostic model; patients in the high risk score group had less favorable survival times, and the prognostic model was negatively associated with B cell infiltration. The present study established a prognostic model using analysis of survival‑related immune‑related genes, which were associated with B cell infiltration.
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November-2020
Volume 20 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Wang H, Wang M, Wang Y, Huang Y, Shi J, Ding Z and Wang W: Prognostic value of immune related genes in lung adenocarcinoma. Oncol Lett 20: 259, 2020
APA
Wang, H., Wang, M., Wang, Y., Huang, Y., Shi, J., Ding, Z., & Wang, W. (2020). Prognostic value of immune related genes in lung adenocarcinoma. Oncology Letters, 20, 259. https://doi.org/10.3892/ol.2020.12122
MLA
Wang, H., Wang, M., Wang, Y., Huang, Y., Shi, J., Ding, Z., Wang, W."Prognostic value of immune related genes in lung adenocarcinoma". Oncology Letters 20.5 (2020): 259.
Chicago
Wang, H., Wang, M., Wang, Y., Huang, Y., Shi, J., Ding, Z., Wang, W."Prognostic value of immune related genes in lung adenocarcinoma". Oncology Letters 20, no. 5 (2020): 259. https://doi.org/10.3892/ol.2020.12122