miR‑4295 promotes cell proliferation, migration and invasion of osteosarcoma through targeting interferon regulatory factor 1

  • Authors:
    • Jin Pei Cheng
    • Bin Huang
    • Jun Hu Duan
    • Kai Jun Yi
    • Zheng Ling Zhuang
  • View Affiliations

  • Published online on: September 18, 2020     https://doi.org/10.3892/ol.2020.12123
  • Article Number: 260
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Osteosarcoma (OS) is the most common form of primary malignant bone tumor. Despite encouraging progress in the treatment of OS, the survival rate for patients with OS has remained unchanged over the past 40 years. It has been established that miRNA plays a crucial regulatory role in the progression and development of OS. To explore the potential association of miRNAs with OS, bioinformatics techniques were used to screen for differentially expressed miRNA genes in OS in the Gene Expression Omnibus database. In the GSE70367 database, it was revealed that miR‑4295 expression was abnormally elevated in the expression of OS cells. To characterize the potential function of miR‑4295 in OS, the expression levels of miR‑4295 in 30 samples of OS and adjacent normal tissues was examined. The results revealed that the expression of miR‑4295 was significantly increased in OS tissues compared with the paired normal tissues. Moreover, the expression levels of miR‑4295 in OS cell lines (MG‑63 and Saos‑2) were significantly higher compared with those in the normal human mesenchymal stem cells. In addition, miR‑4295 was associated with OS cell proliferation, migration and invasion. Furthermore, it was demonstrated that the expression of interferon regulatory factor (IRF)1, a tumor suppressor, was regulated by miR‑4295 directly in OS cells. Taken together, the present results revealed that miR‑4295 may act as a tumor activator by target­ing IRF1 during the progression of OS. Investigating miR‑4295 may provide novel insight into the mechanisms of OS metastasis, and inhibition and targeting miR‑4295 may be a novel therapeutic strategy for the treatment of OS.
View Figures
View References

Related Articles

Journal Cover

November-2020
Volume 20 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Cheng JP, Huang B, Duan JH, Yi KJ and Zhuang ZL: miR‑4295 promotes cell proliferation, migration and invasion of osteosarcoma through targeting interferon regulatory factor 1. Oncol Lett 20: 260, 2020
APA
Cheng, J.P., Huang, B., Duan, J.H., Yi, K.J., & Zhuang, Z.L. (2020). miR‑4295 promotes cell proliferation, migration and invasion of osteosarcoma through targeting interferon regulatory factor 1. Oncology Letters, 20, 260. https://doi.org/10.3892/ol.2020.12123
MLA
Cheng, J. P., Huang, B., Duan, J. H., Yi, K. J., Zhuang, Z. L."miR‑4295 promotes cell proliferation, migration and invasion of osteosarcoma through targeting interferon regulatory factor 1". Oncology Letters 20.5 (2020): 260.
Chicago
Cheng, J. P., Huang, B., Duan, J. H., Yi, K. J., Zhuang, Z. L."miR‑4295 promotes cell proliferation, migration and invasion of osteosarcoma through targeting interferon regulatory factor 1". Oncology Letters 20, no. 5 (2020): 260. https://doi.org/10.3892/ol.2020.12123