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Review Open Access

Dysregulated expression of claudins in cancer (Review)

  • Authors:
    • Jian Li
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    Affiliations: Department of General Surgery, The Third Hospital of Mianyang, Sichuan Mental Health Center, Mianyang, Sichuan 621000, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 641
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    Published online on: July 7, 2021
       https://doi.org/10.3892/ol.2021.12902
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Abstract

Claudins are adhesion molecules located at the tight junctions between epithelial cells. A series of studies have now reported aberrant expression of claudin proteins in the context of neoplastic transformation, suggesting its role in tumorigenesis. However, the precise mechanisms are still not well understood. Studies on expression alterations of claudins have revealed a range of outcomes that reflect the complexity of claudins in terms of spatial localization, tumor type and stage of disease. The diverse and dynamic expression patterns of claudins in cancer are tightly controlled by a wide range of regulatory mechanisms, which are commonly modulated by oncogenic signaling pathways. The present review summarizes the recent knowledge describing the dysregulation of claudin expression in cancer and discusses the intrinsic and extrinsic determinants of the context‑specific expression patterns of claudins.
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1 

Furuse M, Sasaki H, Fujimoto K and Tsukita S: A single gene product, claudin-1 or −2, reconstitutes tight junction strands and recruits occludin in fibroblasts. J Cell Biol. 143:391–401. 1998. View Article : Google Scholar : PubMed/NCBI

2 

Singh AB, Uppada SB and Dhawan P: Claudin proteins, outside-in signaling, and carcinogenesis. Pflugers Arch. 469:69–75. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Hashimoto Y, Tachibana K, Krug SM, Kunisawa J, Fromm M and Kondoh M: Potential for tight junction protein-Directed drug development using claudin binders and angubindin-1. Int J Mol Sci. 20:40162019. View Article : Google Scholar : PubMed/NCBI

4 

Schneeberger EE and Lynch RD: The tight junction: A multifunctional complex. Am J Physiol Cell Physiol. 286:C1213–C1228. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Niessen CM: Tight junctions/adherens junctions: Basic structure and function. J Invest Dermatol. 127:2525–2532. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Meng W and Takeichi M: Adherens junction: Molecular architecture and regulation. Cold Spring Harb Perspect Biol. 1:a0028992009. View Article : Google Scholar : PubMed/NCBI

7 

Kottke MD, Delva E and Kowalczyk AP: The desmosome: Cell science lessons from human diseases. J Cell Sci. 119((Pt 5)): 797–806. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Farquhar MG and Palade GE: Junctional complexes in various epithelia. J Cell Biol. 17:375–412. 1963. View Article : Google Scholar : PubMed/NCBI

9 

Zihni C, Mills C, Matter K and Balda MS: Tight junctions: From simple barriers to multifunctional molecular gates. Nat Rev Mol Cell Biol. 17:564–580. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Lal-Nag M and Morin PJ: The claudins. Genome Biol. 10:2352009. View Article : Google Scholar : PubMed/NCBI

11 

Tsukita S, Tanaka H and Tamura A: The Claudins: From tight junctions to biological systems. Trends Biochem Sci. 44:141–152. 2019. View Article : Google Scholar : PubMed/NCBI

12 

Suzuki H, Nishizawa T, Tani K, Yamazaki Y, Tamura A, Ishitani R, Dohmae N, Tsukita S, Nureki O and Fujiyoshi Y: Crystal structure of a claudin provides insight into the architecture of tight junctions. Science. 344:304–307. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Suzuki H, Tani K, Tamura A, Tsukita S and Fujiyoshi Y: Model for the architecture of claudin-based paracellular ion channels through tight junctions. J Mol Biol. 427:291–297. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Saitoh Y, Suzuki H, Tani K, Nishikawa K, Irie K, Ogura Y, Tamura A, Tsukita S and Fujiyoshi Y: Tight junctions. Structural insight into tight junction disassembly by Clostridium perfringens enterotoxin. Science. 347:775–778. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Shinoda T, Shinya N, Ito K, Ohsawa N, Terada T, Hirata K, Kawano Y, Yamamoto M, Kimura-Someya T, Yokoyama S and Shirouzu M: Structural basis for disruption of claudin assembly in tight junctions by an enterotoxin. Sci Rep. 6:336322016. View Article : Google Scholar : PubMed/NCBI

16 

Nakamura S, Irie K, Tanaka H, Nishikawa K, Suzuki H, Saitoh Y, Tamura A, Tsukita S and Fujiyoshi Y: Morphologic determinant of tight junctions revealed by claudin-3 structures. Nat Commun. 10:8162019. View Article : Google Scholar : PubMed/NCBI

17 

Shen L, Weber CR, Raleigh DR, Yu D and Turner JR: Tight junction pore and leak pathways: A dynamic duo. Annu Rev Physiol. 73:283–309. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Otani T and Furuse M: Tight junction structure and function revisited. Trends Cell Biol. 30:805–817. 2020. View Article : Google Scholar : PubMed/NCBI

19 

Ahmad R, Kumar B, Chen Z, Chen X, Müller D, Lele SM, Washington MK, Batra SK, Dhawan P and Singh AB: Loss of claudin-3 expression induces IL6/gp130/Stat3 signaling to promote colon cancer malignancy by hyperactivating Wnt/β-catenin signaling. Oncogene. 36:6592–6604. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Zhou B, Flodby P, Luo J, Castillo DR, Liu Y, Yu FX, McConnell A, Varghese B, Li G, Chimge NO, et al: Claudin-18-mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis. J Clin Invest. 128:970–984. 2018. View Article : Google Scholar : PubMed/NCBI

21 

Hagen SJ: Non-canonical functions of claudin proteins: Beyond the regulation of cell-cell adhesions. Tissue Barriers. 5:e13278392017. View Article : Google Scholar : PubMed/NCBI

22 

Lu Z, Kim DH, Fan J, Lu Q, Verbanac K, Ding L, Renegar R and Chen YH: A non-tight junction function of claudin-7-Interaction with integrin signaling in suppressing lung cancer cell proliferation and detachment. Mol Cancer. 14:1202015. View Article : Google Scholar : PubMed/NCBI

23 

Nübel T, Preobraschenski J, Tuncay H, Weiss T, Kuhn S, Ladwein M, Langbein L and Zöller M: Claudin-7 regulates EpCAM-mediated functions in tumor progression. Mol Cancer Res. 7:285–299. 2009. View Article : Google Scholar

24 

Pope JL, Bhat AA, Sharma A, Ahmad R, Krishnan M, Washington MK, Beauchamp RD, Singh AB and Dhawan P: Claudin-1 regulates intestinal epithelial homeostasis through the modulation of Notch-signalling. Gut. 63:622–634. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, et al: Systems proteomics view of the endogenous human claudin protein family. J Proteome Res. 15:339–359. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Milatz S and Breiderhoff T: One gene, two paracellular ion channels-claudin-10 in the kidney. Pflugers Arch. 469:115–121. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Li J, Zhang Y, Hu D, Gong T, Xu R and Gao J: Analysis of the expression and genetic alteration of CLDN18 in gastric cancer. Aging (Albany NY). 12:14271–14284. 2020. View Article : Google Scholar : PubMed/NCBI

28 

Milatz S: A novel claudinopathy based on claudin-10 mutations. Int J Mol Sci. 20:53962019. View Article : Google Scholar : PubMed/NCBI

29 

Blanchard AA, Zelinski T, Xie J, Cooper S, Penner C, Leygue E and Myal Y: Identification of claudin 1 transcript variants in human invasive breast cancer. PLoS One. 11:e01633872016. View Article : Google Scholar : PubMed/NCBI

30 

Ben-David U, Nudel N and Benvenisty N: Immunologic and chemical targeting of the tight-junction protein Claudin-6 eliminates tumorigenic human pluripotent stem cells. Nat Commun. 4:19922013. View Article : Google Scholar : PubMed/NCBI

31 

Reinhard K, Rengstl B, Oehm P, Michel K, Billmeier A, Hayduk N, Klein O, Kuna K, Ouchan Y, Wöll S, et al: An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors. Science. 367:446–453. 2020. View Article : Google Scholar : PubMed/NCBI

32 

Erdélyi-Belle B, Török G, Apáti Á, Sarkadi B, Schaff Z, Kiss A and Homolya L: Expression of tight junction components in hepatocyte-like cells differentiated from human embryonic stem cells. Pathol Oncol Res. 21:1059–1070. 2015. View Article : Google Scholar

33 

Fujita H, Chiba H, Yokozaki H, Sakai N, Sugimoto K, Wada T, Kojima T, Yamashita T and Sawada N: Differential expression and subcellular localization of claudin-7, −8, −12, −13, and −15 along the mouse intestine. J Histochem Cytochem. 54:933–944. 2006. View Article : Google Scholar : PubMed/NCBI

34 

D'Souza T, Sherman-Baust CA, Poosala S, Mullin JM and Morin PJ: Age-related changes of claudin expression in mouse liver, kidney, and pancreas. J Gerontol A Biol Sci Med Sci. 64:1146–1153. 2009. View Article : Google Scholar

35 

Perdomo-Ramirez A, Aguirre M, Davitaia T, Ariceta G, Ramos-Trujillo E; RenalTube Group, ; Claverie-Martin F: Characterization of two novel mutations in the claudin-16 and claudin-19 genes that cause familial hypomagnesemia with hypercalciuria and nephrocalcinosis. Gene. 689:227–234. 2019. View Article : Google Scholar : PubMed/NCBI

36 

Ouban A: Claudin-1 role in colon cancer: An update and a review. Histol Histopathol. 33:1013–1019. 2018.PubMed/NCBI

37 

Wang K, Xu C, Li W and Ding L: Emerging clinical significance of claudin-7 in colorectal cancer: A review. Cancer Manag Res. 10:3741–3752. 2018. View Article : Google Scholar : PubMed/NCBI

38 

Dhawan P, Singh AB, Deane NG, No Y, Shiou SR, Schmidt C, Neff J, Washington MK and Beauchamp RD: Claudin-1 regulates cellular transformation and metastatic behavior in colon cancer. J Clin Invest. 115:1765–1776. 2005. View Article : Google Scholar : PubMed/NCBI

39 

Blanchard AA, Skliris GP, Watson PH, Murphy LC, Penner C, Tomes L, Young TL, Leygue E and Myal Y: Claudins 1, 3, and 4 protein expression in ER negative breast cancer correlates with markers of the basal phenotype. Virchows Arch. 454:647–656. 2009. View Article : Google Scholar : PubMed/NCBI

40 

Cherradi S, Ayrolles-Torro A, Vezzo-Vié N, Gueguinou N, Denis V, Combes E, Boissière F, Busson M, Canterel-Thouennon L, Mollevi C, et al: Antibody targeting of claudin-1 as a potential colorectal cancer therapy. J Exp Clin Cancer Res. 36:892017. View Article : Google Scholar : PubMed/NCBI

41 

Matsuoka T, Mitomi H, Fukui N, Kanazawa H, Saito T, Hayashi T and Yao T: Cluster analysis of claudin-1 and −4, E-cadherin, and β-catenin expression in colorectal cancers. J Surg Oncol. 103:674–686. 2011. View Article : Google Scholar : PubMed/NCBI

42 

Bhat AA, Ahmad R, Uppada SB, Singh AB and Dhawan P: Claudin-1 promotes TNF-α-induced epithelial-mesenchymal transition and migration in colorectal adenocarcinoma cells. Exp Cell Res. 349:119–127. 2016. View Article : Google Scholar : PubMed/NCBI

43 

Bornholdt J, Friis S, Godiksen S, Poulsen SS, Santoni-Rugiu E, Bisgaard HC, Lothe IM, Ikdahl T, Tveit KM, Johnson E, et al: The level of claudin-7 is reduced as an early event in colorectal carcinogenesis. BMC Cancer. 11:652011. View Article : Google Scholar : PubMed/NCBI

44 

Tanaka M, Shibahara J, Fukushima N, Shinozaki A, Umeda M, Ishikawa S, Kokudo N and Fukayama M: Claudin-18 is an early-stage marker of pancreatic carcinogenesis. J Histochem Cytochem. 59:942–952. 2011. View Article : Google Scholar : PubMed/NCBI

45 

Stratton MR: Exploring the genomes of cancer cells: Progress and promise. Science. 331:1553–1558. 2011. View Article : Google Scholar : PubMed/NCBI

46 

Gonzalez-Perez A, Perez-Llamas C, Deu-Pons J, Tamborero D, Schroeder MP, Jene-Sanz A, Santos A and Lopez-Bigas N: IntOGen-mutations identifies cancer drivers across tumor types. Nat Methods. 10:1081–1082. 2013. View Article : Google Scholar : PubMed/NCBI

47 

Martínez-Jiménez F, Muiños F, Sentís I, Deu-Pons J, Reyes-Salazar I, Arnedo-Pac C, Mularoni L, Pich O, Bonet J, Kranas H, et al: A compendium of mutational cancer driver genes. Nat Rev Cancer. 20:555–572. 2020. View Article : Google Scholar

48 

Paschoud S, Bongiovanni M, Pache JC and Citi S: Claudin-1 and claudin-5 expression patterns differentiate lung squamous cell carcinomas from adenocarcinomas. Mod Pathol. 20:947–954. 2007. View Article : Google Scholar : PubMed/NCBI

49 

Schaefer MH and Serrano L: Cell type-specific properties and environment shape tissue specificity of cancer genes. Sci Rep. 6:207072016. View Article : Google Scholar : PubMed/NCBI

50 

Honda H, Pazin MJ, D'Souza T, Ji H and Morin PJ: Regulation of the CLDN3 gene in ovarian cancer cells. Cancer Biol Ther. 6:1733–1742. 2007. View Article : Google Scholar : PubMed/NCBI

51 

Di Cello F, Cope L, Li H, Jeschke J, Wang W, Baylin SB and Zahnow CA: Methylation of the claudin 1 promoter is associated with loss of expression in estrogen receptor positive breast cancer. PLoS One. 8:e686302013. View Article : Google Scholar : PubMed/NCBI

52 

Chiang SK, Chang WC, Chen SE and Chang LC: DOCK1 regulates growth and motility through the RRP1B-claudin-1 pathway in claudin-low breast cancer cells. Cancers (Basel). 11:17622019. View Article : Google Scholar : PubMed/NCBI

53 

Li CP, Cai MY, Jiang LJ, Mai SJ, Chen JW, Wang FW, Liao YJ, Chen WH, Jin XH, Pei XQ, et al: CLDN14 is epigenetically silenced by EZH2-mediated H3K27ME3 and is a novel prognostic biomarker in hepatocellular carcinoma. Carcinogenesis. 37:557–566. 2016. View Article : Google Scholar : PubMed/NCBI

54 

Martínez-Estrada OM, Cullerés A, Soriano FX, Peinado H, Bolós V, Martínez FO, Reina M, Cano A, Fabre M and Vilaró S: The transcription factors Slug and Snail act as repressors of Claudin-1 expression in epithelial cells. Biochem J. (394(Pt 2)): 449–457. 2006. View Article : Google Scholar

55 

Bhat AA, Sharma A, Pope J, Krishnan M, Washington MK, Singh AB and Dhawan P: Caudal homeobox protein Cdx-2 cooperates with Wnt pathway to regulate claudin-1 expression in colon cancer cells. PLoS One. 7:e371742012. View Article : Google Scholar : PubMed/NCBI

56 

Feng J, Cen J, Li J, Zhao R, Zhu C, Wang Z, Xie J and Tang W: Histone deacetylase inhibitor valproic acid (VPA) promotes the epithelial mesenchymal transition of colorectal cancer cells via up regulation of Snail. Cell Adh Migr. 9:495–501. 2015. View Article : Google Scholar : PubMed/NCBI

57 

Kohno Y, Okamoto T, Ishibe T, Nagayama S, Shima Y, Nishijo K, Shibata KR, Fukiage K, Otsuka S, Uejima D, et al: Expression of claudin7 is tightly associated with epithelial structures in synovial sarcomas and regulated by an Ets family transcription factor, ELF3. J Biol Chem. 281:38941–38950. 2006. View Article : Google Scholar : PubMed/NCBI

58 

Farkas AE, Hilgarth RS, Capaldo CT, Gerner-Smidt C, Powell DR, Vertino PM, Koval M, Parkos CA and Nusrat A: HNF4alpha regulates claudin-7 protein expression during intestinal epithelial differentiation. Am J Pathol. 185:2206–2218. 2015. View Article : Google Scholar : PubMed/NCBI

59 

Baltzegar DA, Reading BJ, Brune ES and Borski RJ: Phylogenetic revision of the claudin gene family. Mar Genomics. 11:17–26. 2013. View Article : Google Scholar : PubMed/NCBI

60 

Honda H, Pazin MJ, Ji H, Wernyj RP and Morin PJ: Crucial roles of Sp1 and epigenetic modifications in the regulation of the CLDN4 promoter in ovarian cancer cells. J Biol Chem. 281:21433–21444. 2006. View Article : Google Scholar : PubMed/NCBI

61 

Li CF, Chen JY, Ho YH, Hsu WH, Wu LC, Lan HY, Hsu DS, Tai SK, Chang YC and Yang MH: Snail-induced claudin-11 prompts collective migration for tumour progression. Nat Cell Biol. 21:251–262. 2019. View Article : Google Scholar : PubMed/NCBI

62 

Liu M, Yang J, Zhang Y, Zhou Z, Cui X, Zhang L, Fung KM, Zheng W, Allard FD, Yee EU, et al: ZIP4 promotes pancreatic cancer progression by repressing ZO-1 and claudin-1 through a ZEB1-dependent transcriptional mechanism. Clin Cancer Res. 24:3186–3196. 2018. View Article : Google Scholar : PubMed/NCBI

63 

Sun X, Cui S, Fu X, Liu C, Wang Z and Liu Y: MicroRNA-146-5p promotes proliferation, migration and invasion in lung cancer cells by targeting claudin-12. Cancer Biomark. 25:89–99. 2019. View Article : Google Scholar : PubMed/NCBI

64 

Wang YB, Shi Q, Li G, Zheng JH, Lin J and Qiu W: MicroRNA-488 inhibits progression of colorectal cancer via inhibition of the mitogen-activated protein kinase pathway by targeting claudin-2. Am J Physiol Cell Physiol. 316:C33–C47. 2019. View Article : Google Scholar : PubMed/NCBI

65 

Sun H, Cui C, Xiao F, Wang H, Xu J, Shi X, Yang Y, Zhang Q, Zheng X, Yang X, et al: MiR-486 regulates metastasis and chemosensitivity in hepatocellular carcinoma by targeting CLDN10 and CITRON. Hepatol Res. 45:1312–1322. 2015. View Article : Google Scholar : PubMed/NCBI

66 

Zhang SJ, Feng JF, Wang L, Guo W, Du YW, Ming L and Zhao GQ: MiR-1303 targets claudin-18 gene to modulate proliferation and invasion of gastric cancer cells. Dig Dis Sci. 59:1754–1763. 2014. View Article : Google Scholar : PubMed/NCBI

67 

Cheng B, Rong A, Zhou Q and Li W: LncRNA LINC00662 promotes colon cancer tumor growth and metastasis by competitively binding with miR-340-5p to regulate CLDN8/IL22 co-expression and activating ERK signaling pathway. J Exp Clin Cancer Res. 39:52020. View Article : Google Scholar : PubMed/NCBI

68 

Zhang XZ, Mao HL, Zhang SJ, Sun L, Zhang WJ, Chen QZ, Wang L and Liu HC: lncRNA PCAT18 inhibits proliferation, migration and invasion of gastric cancer cells through miR-135b suppression to promote CLDN11 expression. Life Sci. 249:1174782020. View Article : Google Scholar : PubMed/NCBI

69 

Krishnan M, Singh AB, Smith JJ, Sharma A, Chen X, Eschrich S, Yeatman TJ, Beauchamp RD and Dhawan P: HDAC inhibitors regulate claudin-1 expression in colon cancer cells through modulation of mRNA stability. Oncogene. 29:305–312. 2010. View Article : Google Scholar : PubMed/NCBI

70 

Zhou B, Moodie A, Blanchard AA, Leygue E and Myal Y: Claudin 1 in breast cancer: New insights. J Clin Med. 4:1960–1976. 2015. View Article : Google Scholar : PubMed/NCBI

71 

Tanaka M, Kamata R and Sakai R: EphA2 phosphorylates the cytoplasmic tail of Claudin-4 and mediates paracellular permeability. J Biol Chem. 280:42375–42382. 2005. View Article : Google Scholar : PubMed/NCBI

72 

Owari T, Sasaki T, Fujii K, Fujiwara-Tani R, Kishi S, Mori S, Mori T, Goto K, Kawahara I, Nakai Y, et al: Role of nuclear claudin-4 in renal cell carcinoma. Int J Mol Sci. 21:83402020. View Article : Google Scholar : PubMed/NCBI

73 

Heiler S, Mu W, Zöller M and Thuma F: The importance of claudin-7 palmitoylation on membrane subdomain localization and metastasis-promoting activities. Cell Commun Signal. 13:292015. View Article : Google Scholar : PubMed/NCBI

74 

Yuan M, Chen X, Sun Y, Jiang L, Xia Z, Ye K, Jiang H, Yang B, Ying M, Cao J and He Q: ZDHHC12-mediated claudin-3 S-palmitoylation determines ovarian cancer progression. Acta Pharm Sin B. 10:1426–1439. 2020. View Article : Google Scholar : PubMed/NCBI

75 

Mandel I, Paperna T, Volkowich A, Merhav M, Glass-Marmor L and Miller A: The ubiquitin-proteasome pathway regulates claudin 5 degradation. J Cell Biochem. 113:2415–2423. 2012. View Article : Google Scholar : PubMed/NCBI

76 

Gong Y, Wang J, Yang J, Gonzales E, Perez R and Hou J: KLHL3 regulates paracellular chloride transport in the kidney by ubiquitination of claudin-8. Proc Natl Acad Sci USA. 112:4340–4345. 2015. View Article : Google Scholar : PubMed/NCBI

77 

Willemsen LE, Hoetjes JP, van Deventer SJ and van Tol EA: Abrogation of IFN-gamma mediated epithelial barrier disruption by serine protease inhibition. Clin Exp Immunol. 142:275–284. 2005. View Article : Google Scholar : PubMed/NCBI

78 

Lytle NK, Barber AG and Reya T: Stem cell fate in cancer growth, progression and therapy resistance. Nat Rev Cancer. 18:669–680. 2018. View Article : Google Scholar : PubMed/NCBI

79 

Rahner C, Mitic LL and Anderson JM: Heterogeneity in expression and subcellular localization of claudins 2, 3, 4, and 5 in the rat liver, pancreas, and gut. Gastroenterology. 120:411–422. 2001. View Article : Google Scholar : PubMed/NCBI

80 

Paquet-Fifield S, Koh SL, Cheng L, Beyit LM, Shembrey C, Mølck C, Behrenbruch C, Papin M, Gironella M, Guelfi S, et al: Tight junction protein claudin-2 promotes self-renewal of human colorectal cancer stem-like cells. Cancer Res. 78:2925–2938. 2018. View Article : Google Scholar : PubMed/NCBI

81 

Sahin U, Koslowski M, Dhaene K, Usener D, Brandenburg G, Seitz G, Huber C and Türeci O: Claudin-18 splice variant 2 is a pan-cancer target suitable for therapeutic antibody development. Clin Cancer Res. 14:7624–7634. 2008. View Article : Google Scholar : PubMed/NCBI

82 

Akizuki R, Maruhashi R, Eguchi H, Kitabatake K, Tsukimoto M, Furuta T, Matsunaga T, Endo S and Ikari A: Decrease in paracellular permeability and chemosensitivity to doxorubicin by claudin-1 in spheroid culture models of human lung adenocarcinoma A549 cells. Biochim Biophys Acta Mol Cell Res. 1865:769–780. 2018. View Article : Google Scholar : PubMed/NCBI

83 

Kyuno D, Kojima T, Yamaguchi H, Ito T, Kimura Y, Imamura M, Takasawa A, Murata M, Tanaka S, Hirata K and Sawada N: Protein kinase Cα inhibitor protects against downregulation of claudin-1 during epithelial-mesenchymal transition of pancreatic cancer. Carcinogenesis. 34:1232–1243. 2013. View Article : Google Scholar : PubMed/NCBI

84 

Li M, Zhang Y, Liu Z, Bharadwaj U, Wang H, Wang X, Zhang S, Liuzzi JP, Chang SM, Cousins RJ, et al: Aberrant expression of zinc transporter ZIP4 (SLC39A4) significantly contributes to human pancreatic cancer pathogenesis and progression. Proc Natl Acad Sci USA. 104:18636–18641. 2007. View Article : Google Scholar : PubMed/NCBI

85 

Akimoto T, Takasawa A, Takasawa K, Aoyama T, Murata M, Osanai M, Saito T and Sawada N: Estrogen/GPR30 signaling contributes to the malignant potentials of ER-negative cervical adenocarcinoma via regulation of claudin-1 expression. Neoplasia. 20:1083–1093. 2018. View Article : Google Scholar : PubMed/NCBI

86 

Okada T, Konno T, Kohno T, Shimada H, Saito K, Satohisa S, Saito T and Kojima T: Possibility of targeting claudin-2 in therapy for human endometrioid endometrial carcinoma. Reprod Sci. 27:2092–2103. 2020. View Article : Google Scholar : PubMed/NCBI

87 

Domazetovic V, Iantomasi T, Bonanomi AG and Stio M: Vitamin D regulates claudin-2 and claudin-4 expression in active ulcerative colitis by p-Stat-6 and Smad-7 signaling. Int J Colorectal Dis. 35:1231–1242. 2020. View Article : Google Scholar : PubMed/NCBI

88 

Mattern J, Roghi CS, Hurtz M, Knäuper V, Edwards DR and Poghosyan Z: ADAM15 mediates upregulation of claudin-1 expression in breast cancer cells. Sci Rep. 9:125402019. View Article : Google Scholar : PubMed/NCBI

89 

Kim WK, Kwon Y, Jang M, Park M, Kim J, Cho S, Jang DG, Lee WB, Jung SH, Choi HJ, et al: β-catenin activation down-regulates cell-cell junction-related genes and induces epithelial-to-mesenchymal transition in colorectal cancers. Sci Rep. 9:184402019. View Article : Google Scholar : PubMed/NCBI

90 

Rachakonda G, Vu T, Jin L, Samanta D and Datta PK: Role of TGF-β-induced Claudin-4 expression through c-Jun signaling in non-small cell lung cancer. Cell Signal. 28:1537–1544. 2016. View Article : Google Scholar : PubMed/NCBI

91 

Chen YJ, You ML, Chong QY, Pandey V, Zhuang QS, Liu DX, Ma L, Zhu T and Lobie PE: Autocrine human growth hormone promotes invasive and cancer stem cell-like behavior of hepatocellular carcinoma cells by STAT3 dependent inhibition of CLAUDIN-1 expression. Int J Mol Sci. 18:12742017. View Article : Google Scholar : PubMed/NCBI

92 

Chang TL, Ito K, Ko TK, Liu Q, Salto-Tellez M, Yeoh KG, Fukamachi H and Ito Y: Claudin-1 has tumor suppressive activity and is a direct target of RUNX3 in gastric epithelial cells. Gastroenterology. 138:255–265.e1-3. 2010. View Article : Google Scholar : PubMed/NCBI

93 

Ashikari D, Takayama KI, Obinata D, Takahashi S and Inoue S: CLDN8, an androgen-regulated gene, promotes prostate cancer cell proliferation and migration. Cancer Sci. 108:1386–1393. 2017. View Article : Google Scholar : PubMed/NCBI

94 

Mima S, Tsutsumi S, Ushijima H, Takeda M, Fukuda I, Yokomizo K, Suzuki K, Sano K, Nakanishi T, Tomisato W, et al: Induction of claudin-4 by nonsteroidal anti-inflammatory drugs and its contribution to their chemopreventive effect. Cancer Res. 65:1868–1876. 2005. View Article : Google Scholar : PubMed/NCBI

95 

Iitaka D, Moodley S, Shimizu H, Bai XH and Liu M: PKCδ-iPLA2-PGE2-PPARγ signaling cascade mediates TNF-α induced Claudin 1 expression in human lung carcinoma cells. Cell Signal. 27:568–577. 2015. View Article : Google Scholar : PubMed/NCBI

96 

Morin PJ: Claudin proteins in human cancer: Promising new targets for diagnosis and therapy. Cancer Res. 65:9603–9606. 2005. View Article : Google Scholar : PubMed/NCBI

97 

Singh P, Toom S and Huang Y: Anti-claudin 18.2 antibody as new targeted therapy for advanced gastric cancer. J Hematol Oncol. 10:1052017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li J: Dysregulated expression of claudins in cancer (Review). Oncol Lett 22: 641, 2021.
APA
Li, J. (2021). Dysregulated expression of claudins in cancer (Review). Oncology Letters, 22, 641. https://doi.org/10.3892/ol.2021.12902
MLA
Li, J."Dysregulated expression of claudins in cancer (Review)". Oncology Letters 22.3 (2021): 641.
Chicago
Li, J."Dysregulated expression of claudins in cancer (Review)". Oncology Letters 22, no. 3 (2021): 641. https://doi.org/10.3892/ol.2021.12902
Copy and paste a formatted citation
x
Spandidos Publications style
Li J: Dysregulated expression of claudins in cancer (Review). Oncol Lett 22: 641, 2021.
APA
Li, J. (2021). Dysregulated expression of claudins in cancer (Review). Oncology Letters, 22, 641. https://doi.org/10.3892/ol.2021.12902
MLA
Li, J."Dysregulated expression of claudins in cancer (Review)". Oncology Letters 22.3 (2021): 641.
Chicago
Li, J."Dysregulated expression of claudins in cancer (Review)". Oncology Letters 22, no. 3 (2021): 641. https://doi.org/10.3892/ol.2021.12902
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