Medicinal herbs and bioactive compounds overcome the drug resistance to epidermal growth factor receptor inhibitors in non‑small cell lung cancer (Review)

  • Authors:
    • Hiu Yan Jennifer Lee
    • Mingjing Meng
    • Yulong Liu
    • Tao Su
    • Hiu Yee Kwan
  • View Affiliations

  • Published online on: July 8, 2021     https://doi.org/10.3892/ol.2021.12907
  • Article Number: 646
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Abstract

Lung cancer is the leading cause of cancer‑related mortality worldwide. Non‑small cell lung cancer (NSCLC) accounts for ~85% of all lung cancer cases. Patients harboring epidermal growth factor receptor (EGFR) mutations usually develop resistance to treatment with frontline EGFR‑tyrosine kinase inhibitors (EGFR‑TKIs). The present review summarizes the current findings and delineates the molecular mechanism of action for the therapeutic effects of herbal extracts and phytochemicals in overcoming EGFR‑TKI resistance in NSCLC. Novel molecular targets underlying EGFR‑TKI resistance in NSCLC are also discussed. This review provides valuable information for the development of herbal bioactive compounds as alternative treatments for EGFR‑TKI‑resistant NSCLC.
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September-2021
Volume 22 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Lee HY, Meng M, Liu Y, Su T and Kwan HY: Medicinal herbs and bioactive compounds overcome the drug resistance to epidermal growth factor receptor inhibitors in non‑small cell lung cancer (Review). Oncol Lett 22: 646, 2021
APA
Lee, H.Y., Meng, M., Liu, Y., Su, T., & Kwan, H.Y. (2021). Medicinal herbs and bioactive compounds overcome the drug resistance to epidermal growth factor receptor inhibitors in non‑small cell lung cancer (Review). Oncology Letters, 22, 646. https://doi.org/10.3892/ol.2021.12907
MLA
Lee, H. Y., Meng, M., Liu, Y., Su, T., Kwan, H. Y."Medicinal herbs and bioactive compounds overcome the drug resistance to epidermal growth factor receptor inhibitors in non‑small cell lung cancer (Review)". Oncology Letters 22.3 (2021): 646.
Chicago
Lee, H. Y., Meng, M., Liu, Y., Su, T., Kwan, H. Y."Medicinal herbs and bioactive compounds overcome the drug resistance to epidermal growth factor receptor inhibitors in non‑small cell lung cancer (Review)". Oncology Letters 22, no. 3 (2021): 646. https://doi.org/10.3892/ol.2021.12907