Application of natural killer cells in pancreatic cancer (Review)

  • Authors:
    • Xiaobo Peng
    • Ling Chen
    • Yuan Jiao
    • Yujie Wang
    • Zhibin Hao
    • Xianbao Zhan
  • View Affiliations

  • Published online on: July 8, 2021     https://doi.org/10.3892/ol.2021.12908
  • Article Number: 647
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Abstract

Pancreatic cancer, a highly malignant disease, is characterized by rapid progression and early metastasis. Although the integrative treatment of pancreatic cancer has made great progress, the prognosis of patients with advanced pancreatic cancer remains extremely poor. In recent years, with the advancements in tumor immunology, immunotherapy has become a promising remedy for pancreatic cancer. Natural killer (NK) cells are the key lymphocytes in the innate immune system. NK cell function does not require antigen pre‑sensitization and is not major histocompatibility complex restricted. By targeting tumors or virus‑infected cells, the cells play a key role in immune surveillance. Although several questions about NK cells in pancreatic cancer still need to be further studied, there are extensive theories supporting the clinical application prospects of NK cell immunotherapy in pancreatic cancer. Since very few studies have evaluated the role of NK cells in pancreatic cancer, this review provides a comprehensive update of the role of NK cells in pancreatic cancer immunotherapy.
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September-2021
Volume 22 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Peng X, Chen L, Jiao Y, Wang Y, Hao Z and Zhan X: Application of natural killer cells in pancreatic cancer (Review). Oncol Lett 22: 647, 2021
APA
Peng, X., Chen, L., Jiao, Y., Wang, Y., Hao, Z., & Zhan, X. (2021). Application of natural killer cells in pancreatic cancer (Review). Oncology Letters, 22, 647. https://doi.org/10.3892/ol.2021.12908
MLA
Peng, X., Chen, L., Jiao, Y., Wang, Y., Hao, Z., Zhan, X."Application of natural killer cells in pancreatic cancer (Review)". Oncology Letters 22.3 (2021): 647.
Chicago
Peng, X., Chen, L., Jiao, Y., Wang, Y., Hao, Z., Zhan, X."Application of natural killer cells in pancreatic cancer (Review)". Oncology Letters 22, no. 3 (2021): 647. https://doi.org/10.3892/ol.2021.12908