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Article Open Access

Upregulation of CENPF is linked to aggressive features of osteosarcoma

Retraction in: /10.3892/ol.2023.14134
  • Authors:
    • Ping-An Zou
    • Zheng-Xu Yang
    • Xi Wang
    • Zhi-Wei Tao
  • View Affiliations / Copyright

    Affiliations: Department of Bone and Soft Tissue Oncology, Jiangxi Cancer Hospital, Nanchang, Jiangxi 330029, P.R. China
    Copyright: © Zou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 648
    |
    Published online on: July 9, 2021
       https://doi.org/10.3892/ol.2021.12909
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Abstract

Centromere protein F (CENPF) plays a key role in the regulation of the cell cycle. The present study revealed that CENPF was overexpressed in a variety of tumors and associated with the poor prognosis of osteosarcoma. The mRNA expression levels of CENPF were analyzed using the Gene Expression Profiling Interactive Analysis database and the protein levels of CENPF were detected in the specimens from patients with osteosarcoma using immunohistochemistry. Cell proliferation, cell cycle and flow cytometry assays were performed after the transfection of control or CENPF plasmids into osteosarcoma cells. A xenografts assay was used to determine the effects of CENPF on tumor growth in vivo. The results showed that CENPF was upregulated in osteosarcoma tissues and associated with high‑grade tumor stage (P=0.023) and intraglandular dissemination (P=0.046). The transfection‑induced depletion of CENPF in human osteosarcoma MG‑63 and U‑2 OS cell lines inhibited cell proliferation, stimulated apoptosis and induced cell cycle arrest. Induced CENPF depletion in MG‑63 cells inhibited tumor growth of osteosarcoma cells in mice. These findings suggested that elevated CENPF levels contributed to increased cell proliferation by mediating apoptosis and cell cycle in osteosarcoma. Therefore, CENPF might be a potential biomarker for poor prognosis of osteosarcoma.
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Copy and paste a formatted citation
Spandidos Publications style
Zou P, Yang Z, Wang X and Tao Z: Upregulation of CENPF is linked to aggressive features of osteosarcoma Retraction in /10.3892/ol.2023.14134. Oncol Lett 22: 648, 2021.
APA
Zou, P., Yang, Z., Wang, X., & Tao, Z. (2021). Upregulation of CENPF is linked to aggressive features of osteosarcoma Retraction in /10.3892/ol.2023.14134. Oncology Letters, 22, 648. https://doi.org/10.3892/ol.2021.12909
MLA
Zou, P., Yang, Z., Wang, X., Tao, Z."Upregulation of CENPF is linked to aggressive features of osteosarcoma Retraction in /10.3892/ol.2023.14134". Oncology Letters 22.3 (2021): 648.
Chicago
Zou, P., Yang, Z., Wang, X., Tao, Z."Upregulation of CENPF is linked to aggressive features of osteosarcoma Retraction in /10.3892/ol.2023.14134". Oncology Letters 22, no. 3 (2021): 648. https://doi.org/10.3892/ol.2021.12909
Copy and paste a formatted citation
x
Spandidos Publications style
Zou P, Yang Z, Wang X and Tao Z: Upregulation of CENPF is linked to aggressive features of osteosarcoma Retraction in /10.3892/ol.2023.14134. Oncol Lett 22: 648, 2021.
APA
Zou, P., Yang, Z., Wang, X., & Tao, Z. (2021). Upregulation of CENPF is linked to aggressive features of osteosarcoma Retraction in /10.3892/ol.2023.14134. Oncology Letters, 22, 648. https://doi.org/10.3892/ol.2021.12909
MLA
Zou, P., Yang, Z., Wang, X., Tao, Z."Upregulation of CENPF is linked to aggressive features of osteosarcoma Retraction in /10.3892/ol.2023.14134". Oncology Letters 22.3 (2021): 648.
Chicago
Zou, P., Yang, Z., Wang, X., Tao, Z."Upregulation of CENPF is linked to aggressive features of osteosarcoma Retraction in /10.3892/ol.2023.14134". Oncology Letters 22, no. 3 (2021): 648. https://doi.org/10.3892/ol.2021.12909
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