Open Access

Annexin A3 and cancer (Review)

  • Authors:
    • Chao Liu
    • Nannan Li
    • Guijian Liu
    • Xue Feng
  • View Affiliations

  • Published online on: October 14, 2021     https://doi.org/10.3892/ol.2021.13095
  • Article Number: 834
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Annexin A3 (ANXA3), an annexin family member, contains 36 kDa and 33 kDa isoforms. Similar to other annexin members, ANXA3 plays an important role in the development of human diseases. Recent studies have reported that abnormal ANXA3 expression is closely associated with the development, progression, metastasis, drug resistance and prognosis of several malignant tumours, such as breast cancer, lung cancer and hepatocellular carcinoma. ANXA3 exerts its role by regulating cell proliferation, migration and apoptosis via the phosphatidylinositol‑3 kinase/Akt, nuclear factor‑κB (NF‑κB), c‑JUN N‑terminal kinase, extracellular signal‑regulated kinase and hypoxia‑inducible factor‑1 signalling pathways. ANXA3 may act as a novel target for the early diagnosis and treatment of tumours. The present review summarises the recent progress in the role of ANXA3 and its regulatory pathways in tumours.

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December-2021
Volume 22 Issue 6

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Copy and paste a formatted citation
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Spandidos Publications style
Liu C, Li N, Liu G and Feng X: Annexin A3 and cancer (Review). Oncol Lett 22: 834, 2021
APA
Liu, C., Li, N., Liu, G., & Feng, X. (2021). Annexin A3 and cancer (Review). Oncology Letters, 22, 834. https://doi.org/10.3892/ol.2021.13095
MLA
Liu, C., Li, N., Liu, G., Feng, X."Annexin A3 and cancer (Review)". Oncology Letters 22.6 (2021): 834.
Chicago
Liu, C., Li, N., Liu, G., Feng, X."Annexin A3 and cancer (Review)". Oncology Letters 22, no. 6 (2021): 834. https://doi.org/10.3892/ol.2021.13095