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Advances in the application of Let‑7 microRNAs in the diagnosis, treatment and prognosis of leukemia (Review)

  • Authors:
    • Hao Chen
    • Jiewei Wang
    • Huan Wang
    • Jingru Liang
    • Jinhua Dong
    • Houqiao Bai
    • Guosheng Jiang
  • View Affiliations / Copyright

    Affiliations: School of Life Science and Technology, Weifang Medical University, Weifang, Shandong 261053, P.R. China, Department of Transfusion, Jinan Zhangqiu District Maternal and Child Health Care Hospital, Jinan, Shandong 250200, P.R. China, Department of Hematology, The Affiliated Weihai Second Municipal Hospital of Qingdao University, Weihai, Shandong 264200, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 1
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    Published online on: November 2, 2021
       https://doi.org/10.3892/ol.2021.13119
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Abstract

The lethal‑7 (Let‑7) family of microRNAs (miRNAs) controls the process of development and differentiation, but is also related to the occurrence of tumors and a poor prognosis of patients with tumors. Thus, a more comprehensive exploration of its functions will provide further insights into these processes, and may promote the diagnosis and treatment of tumors. Leukemia is a type of progressive malignant disease, and its pathogenesis involves a variety of epigenetic factors. Amongst the several related epigenetic factors, the Let‑7 miRNAs are an important family of molecules that play a crucial role in maintaining a variety of critical biological processes, including development, differentiation and proliferation. In the present study, the role of Let‑7 as a tumor suppressor gene and oncogene is reviewed, and the complex regulatory functions of several Let‑7 family members in different subtypes of leukemia are described. The current body of knowledge thus far indicates that Let‑7 is not only a potential diagnostic and prognostic marker of leukemia, but also a potential therapeutic target for the treatment of affected patients, with particular potential when targeted by adjuvant treatments alongside traditional treatment to improve their survival rate.
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Copy and paste a formatted citation
Spandidos Publications style
Chen H, Wang J, Wang H, Liang J, Dong J, Bai H and Jiang G: Advances in the application of Let‑7 microRNAs in the diagnosis, treatment and prognosis of leukemia (Review). Oncol Lett 23: 1, 2022.
APA
Chen, H., Wang, J., Wang, H., Liang, J., Dong, J., Bai, H., & Jiang, G. (2022). Advances in the application of Let‑7 microRNAs in the diagnosis, treatment and prognosis of leukemia (Review). Oncology Letters, 23, 1. https://doi.org/10.3892/ol.2021.13119
MLA
Chen, H., Wang, J., Wang, H., Liang, J., Dong, J., Bai, H., Jiang, G."Advances in the application of Let‑7 microRNAs in the diagnosis, treatment and prognosis of leukemia (Review)". Oncology Letters 23.1 (2022): 1.
Chicago
Chen, H., Wang, J., Wang, H., Liang, J., Dong, J., Bai, H., Jiang, G."Advances in the application of Let‑7 microRNAs in the diagnosis, treatment and prognosis of leukemia (Review)". Oncology Letters 23, no. 1 (2022): 1. https://doi.org/10.3892/ol.2021.13119
Copy and paste a formatted citation
x
Spandidos Publications style
Chen H, Wang J, Wang H, Liang J, Dong J, Bai H and Jiang G: Advances in the application of Let‑7 microRNAs in the diagnosis, treatment and prognosis of leukemia (Review). Oncol Lett 23: 1, 2022.
APA
Chen, H., Wang, J., Wang, H., Liang, J., Dong, J., Bai, H., & Jiang, G. (2022). Advances in the application of Let‑7 microRNAs in the diagnosis, treatment and prognosis of leukemia (Review). Oncology Letters, 23, 1. https://doi.org/10.3892/ol.2021.13119
MLA
Chen, H., Wang, J., Wang, H., Liang, J., Dong, J., Bai, H., Jiang, G."Advances in the application of Let‑7 microRNAs in the diagnosis, treatment and prognosis of leukemia (Review)". Oncology Letters 23.1 (2022): 1.
Chicago
Chen, H., Wang, J., Wang, H., Liang, J., Dong, J., Bai, H., Jiang, G."Advances in the application of Let‑7 microRNAs in the diagnosis, treatment and prognosis of leukemia (Review)". Oncology Letters 23, no. 1 (2022): 1. https://doi.org/10.3892/ol.2021.13119
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