Advances in the application of Let‑7 microRNAs in the diagnosis, treatment and prognosis of leukemia (Review)
- Authors:
- Hao Chen
- Jiewei Wang
- Huan Wang
- Jingru Liang
- Jinhua Dong
- Houqiao Bai
- Guosheng Jiang
-
Affiliations: School of Life Science and Technology, Weifang Medical University, Weifang, Shandong 261053, P.R. China, Department of Transfusion, Jinan Zhangqiu District Maternal and Child Health Care Hospital, Jinan, Shandong 250200, P.R. China, Department of Hematology, The Affiliated Weihai Second Municipal Hospital of Qingdao University, Weihai, Shandong 264200, P.R. China - Published online on: November 2, 2021 https://doi.org/10.3892/ol.2021.13119
- Article Number: 1
-
Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
|
Hanahan D and Weinberg RA: Hallmarks of cancer: The next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI |
|
|
Pelcovits A and Niroula R: Acute myeloid leukemia: A review. R I Med J (2013). 103:38–40. 2020.PubMed/NCBI |
|
|
Burnett A, Wetzler M and Löwenberg B: Therapeutic advances in acute myeloid leukemia. J Clin Oncol. 29:487–494. 2011. View Article : Google Scholar : PubMed/NCBI |
|
|
Llave C, Xie Z, Kasschau KD and Carrington JC: Cleavage of scarecrow-like mRNA targets directed by a class of Arabidopsis miRNA. Science. 297:2053–2056. 2002. View Article : Google Scholar : PubMed/NCBI |
|
|
Ciardiello F and Tortora G: A novel approach in the treatment of cancer: Targeting the epidermal growth factor receptor. Clin Cancer Res. 7:2958–2970. 2001.PubMed/NCBI |
|
|
Hattori M: Finishing the euchromatic sequence of the human genome. Tanpakushitsu Kakusan Koso. 50:162–168. 2005.(In Japanese). PubMed/NCBI |
|
|
Hunger SP and Mullighan CG: Acute lymphoblastic leukemia in children. N Engl J Med. 373:1541–1552. 2015. View Article : Google Scholar : PubMed/NCBI |
|
|
Mavrea K, Efthymiou V, Katsibardi K, Tsarouhas K, Kanaka-Gantenbein C, Spandidos DA, Chrousos G, Kattamis A and Bacopoulou F: Cognitive function of children and adolescent survivors of acute lymphoblastic leukemia: A meta-analysis. Oncol Lett. 21:2622021. View Article : Google Scholar : PubMed/NCBI |
|
|
Pääkkö E, Harila-Saari A, Vanionpää L, Himanen S, Pyhtinen J and Lanning M: White matter changes on MRI during treatment in children with acute lymphoblastic leukemia: Correlation with neuropsychological findings. Med Pediatr Oncol. 35:456–461. 2000. View Article : Google Scholar : PubMed/NCBI |
|
|
Nelson C and Ambros V: A cohort of caenorhabditis species lacking the highly conserved let-7 microRNA. G3 (Bethesda). 11:jkab0222021. View Article : Google Scholar : PubMed/NCBI |
|
|
Siomi H and Siomi MC: Posttranscriptional regulation of microRNA biogenesis in animals. Mol Cell. 38:323–332. 2010. View Article : Google Scholar : PubMed/NCBI |
|
|
Jiang X, Huang H, Li Z, Li Y, Wang X, Gurbuxani S, Chen P, He C, You D, Zhang S, et al: Blockade of miR-150 maturation by MLL-fusion/MYC/LIN-28 is required for MLL-associated leukemia. Cancer Cell. 22:524–535. 2012. View Article : Google Scholar : PubMed/NCBI |
|
|
Agostini M, Ganini C, Candi E and Melino G: The role of noncoding RNAs in epithelial cancer. Cell Death Discov. 6:132020. View Article : Google Scholar : PubMed/NCBI |
|
|
Virga F, Quirico L, Cucinelli S, Mazzone M, Taverna D and Orso F: MicroRNA-mediated metabolic shaping of the tumor microenvironment. Cancers (Basel). 13:1272021. View Article : Google Scholar : PubMed/NCBI |
|
|
Lan FF, Wang H, Chen YC, Chan CY, Ng SS, Li K, Xie D, He ML, Lin MC and Kung HF: Hsa-let-7g inhibits proliferation of hepatocellular carcinoma cells by downregulation of c-Myc and upregulation of p16(INK4A). Int J Cancer. 128:319–331. 2011. View Article : Google Scholar : PubMed/NCBI |
|
|
Viswanathan SR and Daley GQ: Lin28: A microRNA regulator with a macro role. Cell. 140:445–449. 2010. View Article : Google Scholar : PubMed/NCBI |
|
|
Conti I, Varano G, Simioni C, Laface I, Milani D, Rimondi E and Neri LM: miRNAs as influencers of cell-cell communication in tumor microenvironment. Cells. 9:2202020. View Article : Google Scholar : PubMed/NCBI |
|
|
Linck-Paulus L, Hellerbrand C, Bosserhoff AK and Dietrich P: Dissimilar appearances are deceptive-common microRNAs and therapeutic strategies in liver cancer and melanoma. Cells. 9:1142020. View Article : Google Scholar : PubMed/NCBI |
|
|
Trino S, Lamorte D, Caivano A, Laurenzana I, Tagliaferri D, Falco G, Del Vecchio L, Musto P and De Luca L: MicroRNAs as new biomarkers for diagnosis and prognosis, and as potential therapeutic targets in acute myeloid leukemia. Int J Mol Sci. 19:4602018. View Article : Google Scholar : PubMed/NCBI |
|
|
Wong NW, Chen Y, Chen S and Wang X: OncomiR: An online resource for exploring pan-cancer microRNA dysregulation. Bioinformatics. 34:713–715. 2018. View Article : Google Scholar : PubMed/NCBI |
|
|
Villanueva A, Hoshida Y, Toffanin S, Lachenmayer A, Alsinet C, Savic R, Cornella H and Llovet JM: New strategies in hepatocellular carcinoma: Genomic prognostic markers. Clin Cancer Res. 16:4688–4694. 2010. View Article : Google Scholar : PubMed/NCBI |
|
|
Reinhart BJ, Slack FJ, Basson M, Pasquinelli AE, Bettinger JC, Rougvie AE, Horvitz HR and Ruvkun G: The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature. 403:901–906. 2000. View Article : Google Scholar : PubMed/NCBI |
|
|
Bozgeyik E: Bioinformatic analysis and in vitro validation of Let-7b and Let-7c in breast cancer. Comput Biol Chem. 84:1071912020. View Article : Google Scholar : PubMed/NCBI |
|
|
Lelli D, Pedone C, Majeed M and Sahebkar A: Curcumin and lung cancer: The role of microRNAs. Curr Pharm Des. 23:3440–3444. 2017. View Article : Google Scholar : PubMed/NCBI |
|
|
Rougvie AE: Control of developmental timing in animals. Nat Rev Genet. 2:690–701. 2001. View Article : Google Scholar : PubMed/NCBI |
|
|
Ambros V: microRNAs: Tiny regulators with great potential. Cell. 107:823–826. 2001. View Article : Google Scholar : PubMed/NCBI |
|
|
Büssing I, Slack FJ and Grosshans H: let-7 microRNAs in development, stem cells and cancer. Trends Mol Med. 14:400–409. 2008. View Article : Google Scholar : PubMed/NCBI |
|
|
Nimmo RA and Slack FJ: An elegant miRror: microRNAs in stem cells, developmental timing and cancer. Chromosoma. 118:405–418. 2009. View Article : Google Scholar : PubMed/NCBI |
|
|
Roush S and Slack FJ: The let-7 family of microRNAs. Trends Cell Biol. 18:505–516. 2008. View Article : Google Scholar : PubMed/NCBI |
|
|
Brancati G and Großhans H: An interplay of miRNA abundance and target site architecture determines miRNA activity and specificity. Nucleic Acids Res. 46:3259–3269. 2018. View Article : Google Scholar : PubMed/NCBI |
|
|
Hammond SM: An overview of microRNAs. Adv Drug Deliv Rev. 87:3–14. 2015. View Article : Google Scholar : PubMed/NCBI |
|
|
Perdas E, Stawski R, Kaczka K and Zubrzycka M: Analysis of Let-7 family miRNA in plasma as potential predictive biomarkers of diagnosis for papillary thyroid cancer. Diagnostics (Basel). 10:1302020. View Article : Google Scholar : PubMed/NCBI |
|
|
Jiang S: A regulator of metabolic reprogramming: MicroRNA Let-7. Transl Oncol. 12:1005–1013. 2019. View Article : Google Scholar : PubMed/NCBI |
|
|
Powers JT, Tsanov KM, Pearson DS, Roels F, Spina CS, Ebright R, Seligson M, de Soysa Y, Cahan P, Theißen J, et al: Multiple mechanisms disrupt the let-7 microRNA family in neuroblastoma. Nature. 535:246–251. 2016. View Article : Google Scholar : PubMed/NCBI |
|
|
Wang T, Wang G, Hao D, Liu X, Wang D, Ning N and Li X: Aberrant regulation of the LIN28A/LIN28B and let-7 loop in human malignant tumors and its effects on the hallmarks of cancer. Mol Cancer. 14:1252015. View Article : Google Scholar : PubMed/NCBI |
|
|
Vignali R and Marracci S: HMGA genes and proteins in development and evolution. Int J Mol Sci. 21:6542020. View Article : Google Scholar : PubMed/NCBI |
|
|
Chae HJ, Seo JB, Kim SH, Jeon YJ and Suh SS: Fhit induces the reciprocal suppressions between Lin28/Let-7 and miR-17/92miR. Int J Med Sci. 18:706–714. 2021. View Article : Google Scholar : PubMed/NCBI |
|
|
Chen C, Liu JM and Luo YP: MicroRNAs in tumor immunity: Functional regulation in tumor-associated macrophages. J Zhejiang Univ Sci B. 21:12–28. 2020. View Article : Google Scholar : PubMed/NCBI |
|
|
Sun JD, Li XM, Liu JL, Li J and Zhou H: Effects of miR-150-5p on cerebral infarction rats by regulating the Wnt signaling pathway via p53. Eur Rev Med Pharmacol Sci. 24:3882–3891. 2020.PubMed/NCBI |
|
|
Jia Y and Wei Y: Modulators of MicroRNA function in the immune system. Int J Mol Sci. 21:23572020. View Article : Google Scholar : PubMed/NCBI |
|
|
Khalaj M, Tavakkoli M, Stranahan AW and Park CY: Pathogenic microRNA's in myeloid malignancies. Front Genet. 5:3612014. View Article : Google Scholar : PubMed/NCBI |
|
|
Shaham L, Binder V, Gefen N, Borkhardt A and Izraeli S: MiR-125 in normal and malignant hematopoiesis. Leukemia. 26:2011–2018. 2012. View Article : Google Scholar : PubMed/NCBI |
|
|
Kim VN: Small RNAs: Classification, biogenesis, and function. Mol Cells. 19:1–15. 2005.PubMed/NCBI |
|
|
Jinlong S, Lin F, Yonghui L, Li Y and Weidong W: Identification of let-7a-2-3p or/and miR-188-5p as prognostic biomarkers in cytogenetically normal acute myeloid leukemia. PLoS One. 10:e01180992015. View Article : Google Scholar : PubMed/NCBI |
|
|
Lee H, Han S, Kwon CS and Lee D: Biogenesis and regulation of the let-7 miRNAs and their functional implications. Protein Cell. 7:100–113. 2016. View Article : Google Scholar : PubMed/NCBI |
|
|
Emmrich S, Rasche M, Schöning J, Reimer C, Keihani S, Maroz A, Xie Y, Li Z, Schambach A, Reinhardt D and Klusmann JH: miR-99a/100~125b tricistrons regulate hematopoietic stem and progenitor cell homeostasis by shifting the balance between TGFβ and Wnt signaling. Genes Dev. 28:858–874. 2014. View Article : Google Scholar : PubMed/NCBI |
|
|
Chen Y, Chen S, Lu J, Yuan D, He L, Qin P, Tan H and Xu L: MicroRNA-363-3p promote the development of acute myeloid leukemia with RUNX1 mutation by targeting SPRYD4 and FNDC3B. Medicine (Baltimore). 100:e258072021. View Article : Google Scholar : PubMed/NCBI |
|
|
Ha Sen Ta Na, Nuo M, Meng QT and Xia ZY: The pathway of Let-7a-1/2-3p and HMGB1 mediated dexmedetomidine inhibiting microglia activation in spinal cord ischemia-reperfusion injury mice. J Mol Neurosci. 69:106–114. 2019. View Article : Google Scholar : PubMed/NCBI |
|
|
Zhang H, Luo XQ, Feng DD, Zhang XJ, Wu J, Zheng YS, Chen X, Xu L and Chen YQ: Upregulation of microRNA-125b contributes to leukemogenesis and increases drug resistance in pediatric acute promyelocytic leukemia. Mol Cancer. 10:1082011. View Article : Google Scholar : PubMed/NCBI |
|
|
Ward E, DeSantis C, Robbins A, Kohler B and Jemal A: Childhood and adolescent cancer statistics, 2014. CA Cancer J Clin. 64:83–103. 2014. View Article : Google Scholar : PubMed/NCBI |
|
|
Liao Q, Wang B, Li X and Jiang G: miRNAs in acute myeloid leukemia. Oncotarget. 8:3666–3682. 2017. View Article : Google Scholar : PubMed/NCBI |
|
|
Wang X, Zhang G, Cheng Z, Dai L, Jia L, Jing X, Wang H, Zhang R, Liu M, Jiang T, et al: Knockdown of lncRNA ANRIL inhibits the development of cisplatin resistance by upregulating miR-98 in lung cancer cells. Oncol Rep. 44:1025–1036. 2020. View Article : Google Scholar : PubMed/NCBI |
|
|
Huang Y, Hong X, Hu J and Lu Q: Targeted regulation of MiR-98 on E2F1 increases chemosensitivity of leukemia cells K562/A02. Onco Targets Ther. 10:3233–3239. 2017. View Article : Google Scholar : PubMed/NCBI |
|
|
Kato M and Manabe A: Treatment and biology of pediatric acute lymphoblastic leukemia. Pediatr Int. 60:4–12. 2018. View Article : Google Scholar : PubMed/NCBI |
|
|
Mi S, Lu J, Sun M, Li Z, Zhang H, Neilly MB, Wang Y, Qian Z, Jin J, Zhang Y, et al: MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia. Proc Natl Acad Sci USA. 104:19971–19976. 2007. View Article : Google Scholar : PubMed/NCBI |
|
|
Shafik RE, Abd El Wahab N, Senoun SA, Ebeid E and El Taweel MA: Expression of Micro-RNA 128 and Let-7b in pediatric acute lymphoblastic leukemia cases. Asian Pac J Cancer Prev. 19:2263–2267. 2018.PubMed/NCBI |
|
|
Schotte D, Chau JC, Sylvester G, Liu G, Chen C, van der Velden VH, Broekhuis MJ, Peters TC, Pieters R and den Boer ML: Identification of new microRNA genes and aberrant microRNA profiles in childhood acute lymphoblastic leukemia. Leukemia. 23:313–322. 2009. View Article : Google Scholar : PubMed/NCBI |
|
|
de Oliveira JC, Scrideli CA, Brassesco MS, Morales AG, Pezuk JA, Queiroz Rde P, Yunes JA, Brandalise SR and Tone LG: Differential miRNA expression in childhood acute lymphoblastic leukemia and association with clinical and biological features. Leuk Res. 36:293–298. 2012. View Article : Google Scholar : PubMed/NCBI |
|
|
Zhang H, Luo XQ, Zhang P, Huang LB, Zheng YS, Wu J, Zhou H, Qu LH, Xu L and Chen YQ: MicroRNA patterns associated with clinical prognostic parameters and CNS relapse prediction in pediatric acute leukemia. PLoS One. 4:e78262009. View Article : Google Scholar : PubMed/NCBI |
|
|
Lieberman J: Tapping the RNA world for therapeutics. Nat Struct Mol Biol. 25:357–364. 2018. View Article : Google Scholar : PubMed/NCBI |
|
|
Calin GA, Dumitru CD, Shimizu M, Bichi R, Zupo S, Noch E, Aldler H, Rattan S, Keating M, Rai K, et al: Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci USA. 99:15524–15529. 2002. View Article : Google Scholar : PubMed/NCBI |
|
|
He L, Thomson JM, Hemann MT, Hernando-Monge E, Mu D, Goodson S, Powers S, Cordon-Cardo C, Lowe SW, Hannon GJ and Hammond SM: A microRNA polycistron as a potential human oncogene. Nature. 435:828–833. 2005. View Article : Google Scholar : PubMed/NCBI |
|
|
Lewis BP, Shih IH, Jones-Rhoades MW, Bartel DP and Burge CB: Prediction of mammalian microRNA targets. Cell. 115:787–798. 2003. View Article : Google Scholar : PubMed/NCBI |
|
|
Takamizawa J, Konishi H, Yanagisawa K, Tomida S, Osada H, Endoh H, Harano T, Yatabe Y, Nagino M, Nimura Y, et al: Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival. Cancer Res. 64:3753–3756. 2004. View Article : Google Scholar : PubMed/NCBI |
|
|
Zhang J, Jiang Y, Han X, Roy M, Liu W, Zhao X and Liu J: Differential expression profiles and functional analysis of plasma miRNAs associated with chronic myeloid leukemia phases. Future Oncol. 15:763–776. 2019. View Article : Google Scholar : PubMed/NCBI |
|
|
Dennis G Jr, Sherman BT, Hosack DA, Yang J, Gao W, Lane HC and Lempicki RA: DAVID: Database for annotation, visualization, and integrated discovery. Genome Biol. 4:P32003. View Article : Google Scholar : PubMed/NCBI |
|
|
Ma L, Teruya-Feldstein J and Weinberg RA: Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature. 449:682–688. 2007. View Article : Google Scholar : PubMed/NCBI |
|
|
Mitchell PS, Parkin RK, Kroh EM, Fritz BR, Wyman SK, Pogosova-Agadjanyan EL, Peterson A, Noteboom J, O'Briant KC, Allen A, et al: Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci USA. 105:10513–10518. 2008. View Article : Google Scholar : PubMed/NCBI |
|
|
Ding Y, Wang ZC, Zheng Y, Hu Z, Li Y, Luo DF and Wang SY: C-Myc functions as a competing endogenous RNA in acute promyelocytic leukemia. Oncotarget. 7:56422–56430. 2016. View Article : Google Scholar : PubMed/NCBI |
|
|
Delgado MD and León J: Myc roles in hematopoiesis and leukemia. Genes Cancer. 1:605–616. 2010. View Article : Google Scholar : PubMed/NCBI |
|
|
Nesbit CE, Tersak JM and Prochownik EV: MYC oncogenes and human neoplastic disease. Oncogene. 18:3004–3016. 1999. View Article : Google Scholar : PubMed/NCBI |
|
|
Müller-Tidow C, Steffen B, Cauvet T, Tickenbrock L, Ji P, Diederichs S, Sargin B, Köhler G, Stelljes M, Puccetti E, et al: Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells. Mol Cell Biol. 24:2890–2904. 2004. View Article : Google Scholar : PubMed/NCBI |
|
|
Hoffman B and Liebermann DA: Apoptotic signaling by c-MYC. Oncogene. 27:6462–6472. 2008. View Article : Google Scholar : PubMed/NCBI |
|
|
Johansen LM, Iwama A, Lodie TA, Sasaki K, Felsher DW, Golub TR and Tenen DG: c-Myc is a critical target for c/EBPalpha in granulopoiesis. Mol Cell Biol. 21:3789–3806. 2001. View Article : Google Scholar : PubMed/NCBI |
|
|
Felsher DW and Bishop JM: Reversible tumorigenesis by MYC in hematopoietic lineages. Mol Cell. 4:199–207. 1999. View Article : Google Scholar : PubMed/NCBI |
|
|
Li T, Huang Y, Zhou W and Yan Q: Let-7c-3p regulates autophagy under oxidative stress by targeting ATG3 in lens epithelial cells. Biomed Res Int. 2020:60693902020.PubMed/NCBI |
|
|
Pelosi A, Careccia S, Lulli V, Romania P, Marziali G, Testa U, Lavorgna S, Lo-Coco F, Petti MC, Calabretta B, et al: miRNA let-7c promotes granulocytic differentiation in acute myeloid leukemia. Oncogene. 32:3648–3654. 2013. View Article : Google Scholar : PubMed/NCBI |
|
|
Karreth FA, Tay Y, Perna D, Ala U, Tan SM, Rust AG, DeNicola G, Webster KA, Weiss D, Perez-Mancera PA, et al: In vivo identification of tumor-suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma. Cell. 147:382–395. 2011. View Article : Google Scholar : PubMed/NCBI |
|
|
Fasihi-Ramandi M, Moridnia A, Najafi A and Sharifi M: Inducing apoptosis and decreasing cell proliferation in human acute promyelocytic leukemia through regulation expression of CASP3 by Let-7a-5p blockage. Indian J Hematol Blood Transfus. 34:70–77. 2018. View Article : Google Scholar : PubMed/NCBI |
|
|
Wang W, Corrigan-Cummins M, Barber EA, Saleh LM, Zingone A, Ghafoor A, Costello R, Zhang Y, Kurlander RJ, Korde N, et al: Aberrant levels of miRNAs in bone marrow microenvironment and peripheral blood of myeloma patients and disease progression. J Mol Diagn. 17:669–678. 2015. View Article : Google Scholar : PubMed/NCBI |
|
|
Liu Y, Cheng Z, Pang Y, Cui L, Qian T, Quan L, Zhao H, Shi J, Ke X and Fu L: Role of microRNAs, circRNAs and long noncoding RNAs in acute myeloid leukemia. J Hematol Oncol. 12:512019. View Article : Google Scholar : PubMed/NCBI |
|
|
Li Y, Li P and Wang N: Effect of let-7c on the PI3K/Akt/FoxO signaling pathway in hepatocellular carcinoma. Oncol Lett. 21:962021. View Article : Google Scholar : PubMed/NCBI |
|
|
Yang X, Liu M, Li M, Zhang S, Hiju H, Sun J, Mao Z, Zheng M and Feng B: Epigenetic modulations of noncoding RNA: A novel dimension of cancer biology. Mol Cancer. 19:642020. View Article : Google Scholar : PubMed/NCBI |
|
|
Allegra A, Musolino C, Tonacci A, Pioggia G, Casciaro M and Gangemi S: Clinico-biological implications of modified levels of cytokines in chronic lymphocytic leukemia: A possible therapeutic role. Cancers (Basel). 12:5242020. View Article : Google Scholar : PubMed/NCBI |
|
|
Mauri C and Bosma A: Immune regulatory function of B cells. Annu Rev Immunol. 30:221–241. 2012. View Article : Google Scholar : PubMed/NCBI |
|
|
Bajan S and Hutvagner G: RNA-based therapeutics: From antisense oligonucleotides to miRNAs. Cells. 9:1372020. View Article : Google Scholar : PubMed/NCBI |
|
|
Chakraborty C, Sharma AR, Sharma G and Lee SS: The interplay among miRNAs, major cytokines, and cancer-related inflammation. Mol Ther Nucleic Acids. 20:606–620. 2020. View Article : Google Scholar : PubMed/NCBI |
|
|
Fernandez-Piñeiro I, Badiola I and Sanchez A: Nanocarriers for microRNA delivery in cancer medicine. Biotechnol Adv. 35:350–360. 2017. View Article : Google Scholar : PubMed/NCBI |
