Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
January-2022 Volume 23 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2022 Volume 23 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Diagnostic and prognostic value of serum miR‑145 and vascular endothelial growth factor in non‑small cell lung cancer

  • Authors:
    • Sarayut Lucien Geater
    • Pichitpon Chaniad
    • Keson Trakunram
    • Warangkana Keeratichananont
    • Suhaimee Buya
    • Paramee Thongsuksai
    • Pritsana Raungrut
  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine, Songklanagarind Hospital, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, Thailand, Department of Biomedical Sciences and Biomedical Engineering, Songklanagarind Hospital, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, Thailand, Medical Data Center for Research and Innovation, Songklanagarind Hospital, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, Thailand, Department of Pathology, Songklanagarind Hospital, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, Thailand
    Copyright: © Geater et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 12
    |
    Published online on: November 11, 2021
       https://doi.org/10.3892/ol.2021.13130
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Previous studies have reported the diagnostic and prognostic value of serum microRNA (miR)‑145 and vascular endothelial growth factor (VEGF) levels in various types of cancer; however, their clinical use in non‑small cell lung cancer (NSCLC) remains unclear. The present study included 215 patients, 106 with NSCLC and 109 with other lung diseases (OLDs). miR‑145 expression levels were determined using reverse transcription‑quantitative PCR (RT‑qPCR) and VEGF levels were measured using an ELISA. The diagnostic performance was assessed using a receiver operating characteristic curve and area under the curve (AUC) analysis. A Kaplan‑Meier survival curve and Cox regression analysis were employed to evaluate the prognostic significance of the markers. The biological function of miR‑145 was examined in A549 and H1792 cell lines. The effects of miR‑145 on cell proliferation of NSCLC cells were evaluated by flow cytometry, and the expression levels of miR‑145 and cell cycle‑related genes were determined by RT‑qPCR. The results revealed that miR‑145 and VEGF exhibited fair diagnostic performance [AUC, 0.61 (95% CI, 0.55‑0.68) and AUC, 0.64 (95% CI, 0.57‑0.71), respectively]. Combining age and smoking status with miR‑145 and VEGF provided the best model for differentiating patients with NSCLC from those with OLDs (AUC, 0.76; 95% CI, 0.69‑0.83). Furthermore, low serum miR‑145 levels were associated with poor overall survival [hazard ratio (HR), 0.48; 95% CI, 0.27‑0.85], whereas high VEGF levels were not associated with poor overall survival (HR, 1.47; 95% CI, 0.81‑2.68). In addition, the results of the in vitro experiments indicated that miR‑145 decreased cell proliferation via the induction of cell cycle arrest. In conclusion, the findings of the present study suggested that combining miR‑145 and VEGF levels with clinical risk factors may be a potential diagnostic scheme for NSCLC. In addition, serum miR‑145 may be used as a prognostic marker. These results indicated that miR‑145 may function as a tumor suppressor in NSCLC.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021. View Article : Google Scholar : PubMed/NCBI

2 

Cui M, Wang H, Yao X, Zhang D, Xie Y, Cui R and Zhang X: Circulating MicroRNAs in Cancer: Potential and Challenge. Front Genet. 10:6262019. View Article : Google Scholar : PubMed/NCBI

3 

Hirales Casillas CE, Flores Fernández JM, Padilla Camberos E, Herrera López EJ, Leal Pacheco G and Martínez Velázquez M: Current status of circulating protein biomarkers to aid the early detection of lung cancer. Future Oncol. 10:1501–1513. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Xu W, Chang J, Du X and Hou J: Long non-coding RNA PCAT-1 contributes to tumorigenesis by regulating FSCN1 via miR-145-5p in prostate cancer. Biomed Pharmacother. 95:1112–1118. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Zhang Y, Wen X, Hu XL, Cheng LZ, Yu JY and Wei ZB: Downregulation of miR-145-5p correlates with poor prognosis in gastric cancer. Eur Rev Med Pharmacol Sci. 20:3026–3030. 2016.PubMed/NCBI

7 

Chang Y, Yan W, Sun C, Liu Q, Wang J and Wang M: miR-145-5p inhibits epithelial-mesenchymal transition via the JNK signaling pathway by targeting MAP3K1 in non-small cell lung cancer cells. Oncol Lett. 14:6923–6928. 2017.PubMed/NCBI

8 

Wang M, Wang J, Deng J, Li X, Long W and Chang Y: MiR-145 acts as a metastasis suppressor by targeting metadherin in lung cancer. Med Oncol. 32:3442015. View Article : Google Scholar : PubMed/NCBI

9 

Kieran MW, Kalluri R and Cho YJ: The VEGF pathway in cancer and disease: Responses, resistance, and the path forward. Cold Spring Harb Perspect Med. 2:a0065932012. View Article : Google Scholar : PubMed/NCBI

10 

Zou C, Xu Q, Mao F, Li D, Bian C, Liu LZ, Jiang Y, Chen X, Qi Y, Zhang X, et al: MiR-145 inhibits tumor angiogenesis and growth by N-RAS and VEGF. Cell Cycle. 11:2137–2145. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Chaniad P, Trakunran K, Geater SL, Keeratichananont W, Thongsuksai P and Raungrut P: Serum miRNAs associated with tumor-promoting cytokines in non-small cell lung cancer. PLoS One. 15:e02415932020. View Article : Google Scholar : PubMed/NCBI

12 

Zhang Y, Ta WW, Sun PF, Meng YF and Zhao CZ: Diagnostic and prognostic significance of serum miR-145-5p expression in glioblastoma. Int J Clin Exp Pathol. 12:2536–2543. 2019.PubMed/NCBI

13 

Liang H, Jiang Z, Xie G and Lu Y: Serum microRNA-145 as a novel biomarker in human ovarian cancer. Tumour Biol. 36:5305–5313. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Komatsu H, Oishi T, Itamochi H, Shimada M, Sato S, Chikumi J, Sato S, Nonaka M, Sawada M, Wakahara M, et al: Serum vascular endothelial growth factor-A as a prognostic biomarker for epithelial ovarian cancer. Int J Gynecol Cancer. 27:1325–1332. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Wang RJ, Zheng YH, Wang P and Zhang JZ: Serum miR-125a-5p, miR-145 and miR-146a as diagnostic biomarkers in non-small cell lung cancer. Int J Clin Exp Pathol. 8:765–771. 2015.PubMed/NCBI

16 

Chakra M, Pujol JL, Lamy PJ, Bozonnat MC, Quantin X, Jacot W and Daurès JP: Circulating serum vascular endothelial growth factor is not a prognostic factor of non-small cell lung cancer. J Thorac Oncol. 3:1119–1126. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Shen H, Shen J, Wang L, Shi Z, Wang M, Jiang BH and Shu Y: Low miR-145 expression level is associated with poor pathological differentiation and poor prognosis in non-small cell lung cancer. Biomed Pharmacother. 69:301–305. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Akın Kabalak P, Çiledağ A, Demir N, Çelik G, Yüksel C, Köycü G, Gökmen Öztuna D, Taner A, Kaya A, Kutlay H, et al: Prognostic significance of serum vascular endothelial growth factor and Angiopoietin-2 in patients with lung cancer. Tuberk Toraks. 63:71–77. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Bossuyt PM: Clinical validity: Defining biomarker performance. Scand J Clin Lab Invest Suppl. 242:46–52. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Trakunram K, Chaniad P, Geater SL, Keeratichananont W, Chittithavorn V, Uttayamakul S, Buya S, Raungrut P and Thongsuksai P: Serum miR-339-3p as a potential diagnostic marker for non-small cell lung cancer. Cancer Biol Med. 17:652–663. 2020. View Article : Google Scholar : PubMed/NCBI

21 

Travis WD, Brambilla E, Nicholson AG, Yatabe Y, Austin JHM, Beasley MB, Chirieac LR, Dacic S, Duhig E, Flieder DB, et al WHO Panel, : The 2015 World Health Organization Classification of Lung Tumors: Impact of genetic, clinical and radiologic advances since the 2004 classification. J Thorac Oncol. 10:1243–1260. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Edge SB and Compton CC: The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol. 17:1471–1474. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Rao X, Huang X, Zhou Z and Lin X: An improvement of the 2ˆ(−delta delta CT) method for quantitative real-time polymerase chain reaction data analysis. Biostat Bioinforma Biomath. 3:71–85. 2013.PubMed/NCBI

24 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Li S, Wang L, Meng Y, Chang Y, Xu J and Zhang Q: Increased levels of LAPTM4B, VEGF and survivin are correlated with tumor progression and poor prognosis in breast cancer patients. Oncotarget. 8:41282–41293. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Jiang L, Hochwald S, Deng S, Chen Y, Tan C, Zhong Q and Huang H: Diagnostic and prognostic performance of serum vascular endothelial growth factor, vascular endothelial growth factor receptor 2, and osteopontin for gastrointestinal cancers. Clin Lab. 65:652019. View Article : Google Scholar

27 

Zhang Y, Yu LK, Lu GJ, Xia N, Xie HY, Hu W, Hao KK, Xu CH and Qian Q: Prognostic values of VEGF and endostatin with malignant pleural effusions in patients with lung cancer. Asian Pac J Cancer Prev. 15:8435–8440. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Wozniak MB, Scelo G, Muller DC, Mukeria A, Zaridze D and Brennan P: Circulating microRNAs as non-invasive biomarkers for early detection of non-small-cell lung cancer. PLoS One. 10:e01250262015. View Article : Google Scholar : PubMed/NCBI

29 

Shimanuki Y, Takahashi K, Cui R, Hori S, Takahashi F, Miyamoto H and Fukurchi Y: Role of serum vascular endothelial growth factor in the prediction of angiogenesis and prognosis for non-small cell lung cancer. Lung. 183:29–42. 2005. View Article : Google Scholar : PubMed/NCBI

30 

Zeinali T, Karimi L, Hosseinahli N, Shanehbandi D, Mansoori B, Mohammadi A, Hajiasgharzadeh K, Babaloo Z, Majidi-Zolbanin J and Baradaran B: Overexpression of miRNA-145 induces apoptosis and prevents proliferation and migration of MKN-45 gastric cancer cells. EXCLI J. 19:1446–1458. 2020.PubMed/NCBI

31 

Ding W, Tan H, Zhao C, Li X, Li Z, Jiang C, Zhang Y and Wang L: MiR-145 suppresses cell proliferation and motility by inhibiting ROCK1 in hepatocellular carcinoma. Tumour Biol. 37:6255–6260. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Pan Y, Ye C, Tian Q, Yan S, Zeng X, Xiao C, Wang L and Wang H: miR-145 suppresses the proliferation, invasion and migration of NSCLC cells by regulating the BAX/BCL-2 ratio and the caspase-3 cascade. Oncol Lett. 15:4337–4343. 2018.PubMed/NCBI

33 

Ye Z, Shen N, Weng Y, Li K, Hu L, Liao H, An J, Liu L, Lao S and Cai S: Low miR-145 silenced by DNA methylation promotes NSCLC cell proliferation, migration and invasion by targeting mucin 1. Cancer Biol Ther. 16:1071–1079. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Chen Z, Zeng H, Guo Y, Liu P, Pan H, Deng A and Hu J: miRNA-145 inhibits non-small cell lung cancer cell proliferation by targeting c-Myc. J Exp Clin Cancer Res. 29:1512010. View Article : Google Scholar : PubMed/NCBI

35 

Fan L, Wu Q, Xing X, Wei Y and Shao Z: MicroRNA-145 targets vascular endothelial growth factor and inhibits invasion and metastasis of osteosarcoma cells. Acta Biochim Biophys Sin (Shanghai). 44:407–414. 2012. View Article : Google Scholar : PubMed/NCBI

36 

Li YQ, He QM, Ren XY, Tang XR, Xu YF, Wen X, Yang XJ, Ma J and Liu N: MiR-145 inhibits metastasis by targeting fascin actin-bundling protein 1 in nasopharyngeal carcinoma. PLoS One. 10:e01222282015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Geater SL, Chaniad P, Trakunram K, Keeratichananont W, Buya S, Thongsuksai P and Raungrut P: Diagnostic and prognostic value of serum miR‑145 and vascular endothelial growth factor in non‑small cell lung cancer. Oncol Lett 23: 12, 2022.
APA
Geater, S.L., Chaniad, P., Trakunram, K., Keeratichananont, W., Buya, S., Thongsuksai, P., & Raungrut, P. (2022). Diagnostic and prognostic value of serum miR‑145 and vascular endothelial growth factor in non‑small cell lung cancer. Oncology Letters, 23, 12. https://doi.org/10.3892/ol.2021.13130
MLA
Geater, S. L., Chaniad, P., Trakunram, K., Keeratichananont, W., Buya, S., Thongsuksai, P., Raungrut, P."Diagnostic and prognostic value of serum miR‑145 and vascular endothelial growth factor in non‑small cell lung cancer". Oncology Letters 23.1 (2022): 12.
Chicago
Geater, S. L., Chaniad, P., Trakunram, K., Keeratichananont, W., Buya, S., Thongsuksai, P., Raungrut, P."Diagnostic and prognostic value of serum miR‑145 and vascular endothelial growth factor in non‑small cell lung cancer". Oncology Letters 23, no. 1 (2022): 12. https://doi.org/10.3892/ol.2021.13130
Copy and paste a formatted citation
x
Spandidos Publications style
Geater SL, Chaniad P, Trakunram K, Keeratichananont W, Buya S, Thongsuksai P and Raungrut P: Diagnostic and prognostic value of serum miR‑145 and vascular endothelial growth factor in non‑small cell lung cancer. Oncol Lett 23: 12, 2022.
APA
Geater, S.L., Chaniad, P., Trakunram, K., Keeratichananont, W., Buya, S., Thongsuksai, P., & Raungrut, P. (2022). Diagnostic and prognostic value of serum miR‑145 and vascular endothelial growth factor in non‑small cell lung cancer. Oncology Letters, 23, 12. https://doi.org/10.3892/ol.2021.13130
MLA
Geater, S. L., Chaniad, P., Trakunram, K., Keeratichananont, W., Buya, S., Thongsuksai, P., Raungrut, P."Diagnostic and prognostic value of serum miR‑145 and vascular endothelial growth factor in non‑small cell lung cancer". Oncology Letters 23.1 (2022): 12.
Chicago
Geater, S. L., Chaniad, P., Trakunram, K., Keeratichananont, W., Buya, S., Thongsuksai, P., Raungrut, P."Diagnostic and prognostic value of serum miR‑145 and vascular endothelial growth factor in non‑small cell lung cancer". Oncology Letters 23, no. 1 (2022): 12. https://doi.org/10.3892/ol.2021.13130
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team