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Cordycepin inhibits the proliferation and progression of NPC by targeting the MAPK/ERK and β‑catenin pathways

  • Authors:
    • Yaqi Zhou
    • Xueshuang Mei
    • Ying Li
    • Weiqiang Yang
    • Xi Su
    • Hongyi Hu
  • View Affiliations / Copyright

    Affiliations: Department of Otorhinolaryngology, Peking University Shenzhen Hospital, Shenzhen Peking University‑The Hong Kong University of Science and Technology Medical Centre, Shenzhen, Guangdong 518000, P.R. China, Department of Radiology, Peking University Shenzhen Hospital, Shenzhen Peking University‑The Hong Kong University of Science and Technology Medical Centre, Shenzhen, Guangdong 518000, P.R. China, Department of Thyroid and Breast Surgery, Peking University Shenzhen Hospital, Shenzhen Peking University‑The Hong Kong University of Science and Technology Medical Centre, Shenzhen, Guangdong 518000, P.R. China
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 20
    |
    Published online on: November 16, 2021
       https://doi.org/10.3892/ol.2021.13138
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Abstract

Cordycepin is an extract from the Cordyceps genus of ascomycete fungi. In the present study, the anticancer potential of cordycepin against nasopharyngeal carcinoma (NPC), and the potential underlying mechanisms, were investigated. Using Cell Counting Kit 8, wound‑healing and Transwell assays, cordycepin was found to reduce the viability and inhibit the migration of C666‑1 cells in a dose‑dependent manner. In addition, in colony formation assays, co‑treatment with cordycepin and cisplatin inhibited the proliferation of C666‑1 cells. Furthermore, RNA sequencing analysis identified 72 significantly differentially expressed genes and different signaling pathways that may be regulated by cordycepin. After treatment with cordycepin, the expression levels of ERK1/2, phosphorylated ERK1/2 and β‑catenin were significantly downregulated. Therefore, cordycepin may be a novel candidate for NPC treatment or a co‑treatment candidate with cisplatin in chemotherapy.
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1 

Chen YP, Chan ATC, Le QT, Blanchard P, Sun Y and Ma J: Nasopharyngeal carcinoma. Lancet. 394:64–80. 2019. View Article : Google Scholar : PubMed/NCBI

2 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Lee AW, Ng WT, Chan LL, Hung WM, Chan CC, Sze HC, Chan OS, Chang AT and Yeung RM: Evolution of treatment for nasopharyngeal cancer - success and setback in the intensity-modulated radiotherapy era. Radiother Oncol. 110:377–384. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Colevas AD, Yom SS, Pfister DG, Spencer S, Adelstein D, Adkins D, Brizel DM, Burtness B, Busse PM, Caudell JJ, et al: NCCN Guidelines Insights: Head and Neck Cancers, Version 1.2018. J Natl Compr Canc Netw. 16:479–490. 2018. View Article : Google Scholar : PubMed/NCBI

5 

Zhang Y, Chen L, Hu GQ, Zhang N, Zhu XD, Yang KY, Jin F, Shi M, Chen YP, Hu WH, et al: Gemcitabine and Cisplatin Induction Chemotherapy in Nasopharyngeal Carcinoma. N Engl J Med. 381:1124–1135. 2019. View Article : Google Scholar : PubMed/NCBI

6 

Huang YM, Qiao SQ, Lu L, Chen WP, Li SL and Qi CH: Gemcitabine combined with cisplatin vs. taxane, cisplatin, and fluorouracil in the treatment of locally advanced nasopharyngeal carcinoma: A retrospective case-control study. Eur Rev Med Pharmacol Sci. 24:7655–7663. 2020.PubMed/NCBI

7 

Lu Y, Chen D, Liang J, Gao J, Luo Z, Wang R, Liu W, Huang C, Ning X, Liu M, et al: Administration of nimotuzumab combined with cisplatin plus 5-fluorouracil as induction therapy improves treatment response and tolerance in patients with locally advanced nasopharyngeal carcinoma receiving concurrent radiochemotherapy: A multicenter randomized controlled study. BMC Cancer. 19:12622019. View Article : Google Scholar : PubMed/NCBI

8 

Jin T, Qin WF, Jiang F, Jin QF, Wei QC, Jia YS, Sun XN, Li WF and Chen XZ: Cisplatin and Fluorouracil Induction Chemotherapy With or Without Docetaxel in Locoregionally Advanced Nasopharyngeal Carcinoma. Transl Oncol. 12:633–639. 2019. View Article : Google Scholar : PubMed/NCBI

9 

Li Y, Li S, Meng X, Gan RY, Zhang JJ and Li HB: Dietary Natural Products for Prevention and Treatment of Breast Cancer. Nutrients. 9:E7282017. View Article : Google Scholar

10 

Luo H, Vong CT, Chen H, Gao Y, Lyu P, Qiu L, Zhao M, Liu Q, Cheng Z, Zou J, et al: Naturally occurring anti-cancer compounds: Shining from Chinese herbal medicine. Chin Med. 14:482019. View Article : Google Scholar : PubMed/NCBI

11 

Tuli HS, Sharma AK, Sandhu SS and Kashyap D: Cordycepin: A bioactive metabolite with therapeutic potential. Life Sci. 93:863–869. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Zhu X, Shen H, Yin X, Long L, Xie C, Liu Y, Hui L, Lin X, Fang Y, Cao Y, et al: miR-186 regulation of Twist1 and ovarian cancer sensitivity to cisplatin. Oncogene. 35:323–332. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Guo Z, Chen W, Dai G and Huang Y: Cordycepin suppresses the migration and invasion of human liver cancer cells by downregulating the expression of CXCR4. Int J Mol Med. 45:141–150. 2020.PubMed/NCBI

14 

Ho SY, Wu WS, Lin LC, Wu YH, Chiu HW, Yeh YL, Huang BM and Wang YJ: Cordycepin Enhances Radiosensitivity in Oral Squamous Carcinoma Cells by Inducing Autophagy and Apoptosis Through Cell Cycle Arrest. Int J Mol Sci. 20:E53662019. View Article : Google Scholar

15 

Wei C, Yao X, Jiang Z, Wang Y, Zhang D, Chen X, Fan X, Xie C, Cheng J, Fu J, et al: Cordycepin Inhibits Drug-resistance Non-small Cell Lung Cancer Progression by Activating AMPK Signaling Pathway. Pharmacol Res. 144:79–89. 2019. View Article : Google Scholar : PubMed/NCBI

16 

Khan MA and Tania M: Cordycepin in Anticancer Research: Molecular Mechanism of Therapeutic Effects. Curr Med Chem. 27:983–996. 2020. View Article : Google Scholar : PubMed/NCBI

17 

Yoon SY, Park SJ and Park YJ: The Anticancer Properties of Cordycepin and Their Underlying Mechanisms. Int J Mol Sci. 19:E30272018. View Article : Google Scholar

18 

Knapek KJ, Georges HM, Van Campen H, Bishop JV, Bielefeldt-Ohmann H, Smirnova NP and Hansen TR: Fetal Lymphoid Organ Immune Responses to Transient and Persistent Infection with Bovine Viral Diarrhea Virus. Viruses. 12:E8162020. View Article : Google Scholar : PubMed/NCBI

19 

Cheung ST, Huang DP, Hui AB, Lo KW, Ko CW, Tsang YS, Wong N, Whitney BM and Lee JC: Nasopharyngeal carcinoma cell line (C666-1) consistently harbouring Epstein-Barr virus. Int J Cancer. 83:121–126. 1999. View Article : Google Scholar : PubMed/NCBI

20 

Chang MM, Hong SY, Yang SH, Wu CC, Wang CY and Huang BM: Anti-Cancer Effect of Cordycepin on FGF9-Induced Testicular Tumorigenesis. Int J Mol Sci. 21:E83362020. View Article : Google Scholar

21 

Wang Z, Wu X, Liang YN, Wang L, Song ZX, Liu JL and Tang ZS: Cordycepin Induces Apoptosis and Inhibits Proliferation of Human Lung Cancer Cell Line H1975 via Inhibiting the Phosphorylation of EGFR. Molecules. 21:E12672016. View Article : Google Scholar

22 

Chen Y, Yang SH, Hueng DY, Syu JP, Liao CC and Wu YC: Cordycepin induces apoptosis of C6 glioma cells through the adenosine 2A receptor-p53-caspase-7-PARP pathway. Chem Biol Interact. 216:17–25. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Lee SY, Debnath T, Kim SK and Lim BO: Anti-cancer effect and apoptosis induction of cordycepin through DR3 pathway in the human colonic cancer cell HT-29. Food Chemical Toxicol. 60:439–447. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Tao X, Ning Y, Zhao X and Pan T: The effects of cordycepin on the cell proliferation, migration and apoptosis in human lung cancer cell lines A549 and NCI-H460. J Pharm Pharmacol. 68:901–911. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Li XY, Tao H, Jin C, Du ZY, Liao WF, Tang QJ and Ding K: Cordycepin inhibits pancreatic cancer cell growth in vitro and in vivo via targeting FGFR2 and blocking ERK signaling. Chin J Nat Med. 18:345–355. 2020.PubMed/NCBI

26 

Chen YH, Wang JY, Pan BS, Mu YF, Lai MS, So EC, Wong TS and Huang BM: Cordycepin enhances cisplatin apoptotic effect through caspase/MAPK pathways in human head and neck tumor cells. OncoTargets Ther. 6:983–998. 2013.PubMed/NCBI

27 

Gao Y, Chen DL, Zhou M, Zheng ZS, He MF, Huang S, Liao XZ and Zhang JX: Cordycepin enhances the chemosensitivity of esophageal cancer cells to cisplatin by inducing the activation of AMPK and suppressing the AKT signaling pathway. Cell Death Dis. 11:8662020. View Article : Google Scholar : PubMed/NCBI

28 

Clevers H and Nusse R: Wnt/β-catenin signaling and disease. Cell. 149:1192–1205. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Krishnamurthy N and Kurzrock R: Targeting the Wnt/beta-catenin pathway in cancer: Update on effectors and inhibitors. Cancer Treat Rev. 62:50–60. 2018. View Article : Google Scholar : PubMed/NCBI

30 

Su NW, Wu SH, Chi CW, Liu CJ, Tsai TH and Chen YJ: Metronomic Cordycepin Therapy Prolongs Survival of Oral Cancer-Bearing Mice and Inhibits Epithelial-Mesenchymal Transition. Molecules. 22:E6292017. View Article : Google Scholar

31 

Liu T, Zhu G, Yan W, Lv Y, Wang X, Jin G, Cui M, Lin Z and Ren X: Cordycepin Inhibits Cancer Cell Proliferation and Angiogenesis through a DEK Interaction via ERK Signaling in Cholangiocarcinoma. J Pharmacol Exp Ther. 373:279–289. 2020. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhou Y, Mei X, Li Y, Yang W, Su X and Hu H: Cordycepin inhibits the proliferation and progression of NPC by targeting the MAPK/ERK and β‑catenin pathways. Oncol Lett 23: 20, 2022.
APA
Zhou, Y., Mei, X., Li, Y., Yang, W., Su, X., & Hu, H. (2022). Cordycepin inhibits the proliferation and progression of NPC by targeting the MAPK/ERK and β‑catenin pathways. Oncology Letters, 23, 20. https://doi.org/10.3892/ol.2021.13138
MLA
Zhou, Y., Mei, X., Li, Y., Yang, W., Su, X., Hu, H."Cordycepin inhibits the proliferation and progression of NPC by targeting the MAPK/ERK and β‑catenin pathways". Oncology Letters 23.1 (2022): 20.
Chicago
Zhou, Y., Mei, X., Li, Y., Yang, W., Su, X., Hu, H."Cordycepin inhibits the proliferation and progression of NPC by targeting the MAPK/ERK and β‑catenin pathways". Oncology Letters 23, no. 1 (2022): 20. https://doi.org/10.3892/ol.2021.13138
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou Y, Mei X, Li Y, Yang W, Su X and Hu H: Cordycepin inhibits the proliferation and progression of NPC by targeting the MAPK/ERK and β‑catenin pathways. Oncol Lett 23: 20, 2022.
APA
Zhou, Y., Mei, X., Li, Y., Yang, W., Su, X., & Hu, H. (2022). Cordycepin inhibits the proliferation and progression of NPC by targeting the MAPK/ERK and β‑catenin pathways. Oncology Letters, 23, 20. https://doi.org/10.3892/ol.2021.13138
MLA
Zhou, Y., Mei, X., Li, Y., Yang, W., Su, X., Hu, H."Cordycepin inhibits the proliferation and progression of NPC by targeting the MAPK/ERK and β‑catenin pathways". Oncology Letters 23.1 (2022): 20.
Chicago
Zhou, Y., Mei, X., Li, Y., Yang, W., Su, X., Hu, H."Cordycepin inhibits the proliferation and progression of NPC by targeting the MAPK/ERK and β‑catenin pathways". Oncology Letters 23, no. 1 (2022): 20. https://doi.org/10.3892/ol.2021.13138
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