Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
January-2022 Volume 23 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2022 Volume 23 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Identification of two downregulated circRNAs in patients with acute B‑lymphocytic leukemia

  • Authors:
    • Bo Zhou
    • Liansheng Zhong
    • Liu Tian
    • Ye Zhang
    • Runan Wang
    • Qun He
    • Yujie Zhao
  • View Affiliations / Copyright

    Affiliations: Key Laboratory of Cell Biology of Ministry of Public Health, College of Life Sciences, China Medical University, Shenyang, Liaoning 110122, P.R. China, Department of Bioinformatics, College of Life Sciences, China Medical University, Shenyang, Liaoning 110122, P.R. China, Psychiatry and Mental Health Center, Shenyang Mental Health Center, Shenyang, Liaoning 110122, P.R. China, Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110122, P.R. China
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 40
    |
    Published online on: December 3, 2021
       https://doi.org/10.3892/ol.2021.13158
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Acute B‑lymphocytic leukemia (B‑ALL) is associated with a high mortality rate, with no effective treatment strategies available. The identification of diagnostic and prognostic biomarkers of B‑ALL can contribute to the development of novel therapeutic methods and drugs, which can improve the survival outcomes of patients with B‑ALL. The present study aimed to identify downregulated circular RNAs (circRNAs) in patients with B‑ALL. RNA sequencing was performed to construct the circRNA expression profiles in B‑ALL cells and normal human lymphoblasts. The Database for Annotation, Visualization and Integrated Discovery was used to perform Gene Ontology enrichment and Kyoto Encyclopedia of Genes and Genomes pathway analyses. In addition, reverse transcription‑quantitative (RT‑q)PCR analysis was performed to detect the expression levels of the downregulated circRNAs. A total of 263 differentially expressed circRNAs were identified, including 76 upregulated and 187 downregulated circRNAs, respectively. The upregulated circRNAs were mainly enriched in ‘macromolecule modification’, ‘protein modification’ and ‘cellular protein modification processes’, while the downregulated circRNAs were mainly enriched in the ‘negative regulation of RNA biosynthetic processes’, ‘natural killer cell‑mediated cytotoxicity’ and ‘viral carcinogenesis’. RT‑qPCR analysis demonstrated that two of the downregulated circRNAs (hsa_circ_0000745 and chr15:87949594‑87966067‑), identified during microarray analysis were also significantly downregulated in Ball‑1 cells and B‑ALL bone marrow samples. Thus, these circRNAs may serve as biomarkers for patients with B‑ALL.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Kantarjian HM, Keating MJ and Freireich EJ: Toward the potential cure of leukemias in the next decade. Cancer. 124:4301–4313. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Miranda-Filho A, Piñeros M, Ferlay J, Soerjomataram I, Monnereau A and Bray F: Epidemiological patterns of leukaemia in 184 countries: A population-based study. Lancet Haematol. 5:e14–e24. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Atsuta Y, Kato S, Morishima Y, Ohashi K, Fukuda T, Ozawa Y, Eto T, Iwato K, Uchida N, Ota S, et al HLA Working Group of the Japan Society for Hematopoietic Cell Transplantation, : Comparison of HLA allele mismatch and antigen mismatch in unrelated bone marrow transplantation in patients with leukemia. Biol Blood Marrow Transplant. 25:436–442. 2019. View Article : Google Scholar : PubMed/NCBI

4 

Chung C and Ma H: Driving toward precision medicine for acute leukemias: Are we there yet? Pharmacotherapy. 37:1052–1072. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Fousek K, Watanabe J, Joseph SK, George A, An X, Byrd TT, Morris JS, Luong A, Martínez-Paniagua MA, Sanber K, et al: CAR T-cells that target acute B-lineage leukemia irrespective of CD19 expression. Leukemia. 35:75–89. 2021. View Article : Google Scholar : PubMed/NCBI

6 

Davila ML, Riviere I, Wang X, Bartido S, Park J, Curran K, Chung SS, Stefanski J, Borquez-Ojeda O, Olszewska M, et al: Efficacy and toxicity management of 19–28z CAR T cell therapy in B cell acute lymphoblastic leukemia. Sci Transl Med. 6:224ra252014. View Article : Google Scholar : PubMed/NCBI

7 

Tambaro FP, Garcia-Manero G, O'Brien SM, Faderl SH, Ferrajoli A, Burger JA, Pierce S, Wang X, Do KA, Kantarjian HM, et al: Outcomes for patients with chronic lymphocytic leukemia and acute leukemia or myelodysplastic syndrome. Leukemia. 30:325–330. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Chen LL and Yang L: Regulation of circRNA biogenesis. RNA Biol. 12:381–388. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Patop IL, Wüst S and Kadener S: Past, present, and future of circRNAs. EMBO J. 38:e1008362019. View Article : Google Scholar : PubMed/NCBI

10 

Zhang HD, Jiang LH, Sun DW, Hou JC and Ji ZL: circRNA: A novel type of biomarker for cancer. Breast Cancer. 25:1–7. 2018. View Article : Google Scholar : PubMed/NCBI

11 

Qu S, Yang X, Li X, Wang J, Gao Y, Shang R, Sun W, Dou K and Li H: Circular RNA: A new star of noncoding RNAs. Cancer Lett. 365:141–148. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Shuai M, Hong J, Huang D, Zhang X and Tian Y: Upregulation of circRNA_0000285 serves as a prognostic biomarker for nasopharyngeal carcinoma and is involved in radiosensitivity. Oncol Lett. 16:6495–6501. 2018.PubMed/NCBI

13 

Lin G, Sheng H, Xie H, Zheng Q, Shen Y, Shi G and Ye D: circLPAR1 is a novel biomarker of prognosis for muscle-invasive bladder cancer with invasion and metastasis by miR-762. Oncol Lett. 17:3537–3547. 2019.PubMed/NCBI

14 

Chaichian S, Shafabakhsh R, Mirhashemi SM, Moazzami B and Asemi Z: Circular RNAs: A novel biomarker for cervical cancer. J Cell Physiol. 235:718–724. 2020. View Article : Google Scholar : PubMed/NCBI

15 

Cui L, Li ZG, Chai YH, Yu J, Gao J, Zhu XF, Jin RM, Shi XD, Zhang LP, Gao YJ, et al; Chinese Children Leukemia Group (CCLG), . Outcome of children with newly diagnosed acute lymphoblastic leukemia treated with CCLG-ALL 2008: The first nation-wide prospective multicenter study in China. Am J Hematol. 93:913–920. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Vardiman JW, Thiele J, Arber DA, Brunning RD, Borowitz MJ, Porwit A, Harris NL, Le Beau MM, Hellström-Lindberg E, Tefferi A, et al: The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: Rationale and important changes. Blood. 114:937–951. 2009. View Article : Google Scholar : PubMed/NCBI

17 

He M, Dong C, Konishi T, Tu W, Liu W, Shiomi N, Kobayashi A, Uchihori Y, Furusawa Y, Hei TK, et al: Differential effects of p53 on bystander phenotypes induced by gamma ray and high LET heavy ion radiation. Life Sci Space Res (Amst). 1:53–59. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Ye S, Yuan D, Xie Y, Pan Y and Shao C: Role of DNA methylation in long-term low-dose γ-rays induced adaptive response in human B lymphoblast cells. Int J Radiat Biol. 89:898–906. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Liu L, Tan Q, Hu B, Wu H, Wang C, Liu R and Tang C: Somatostatin improved B cells mature in macaques during intestinal ischemia-reperfusion. PLoS One. 10:e01336922015. View Article : Google Scholar : PubMed/NCBI

20 

Ye S, Yuan D, Xie Y, Pan Y and Shao C: Role of DNA methylation in the adaptive responses induced in a human B lymphoblast cell line by long-term low-dose exposures to γ-rays and cadmium. Mutat Res Genet Toxicol Environ Mutagen. 773:34–38. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Kim D, Pertea G, Trapnell C, Pimentel H, Kelley R and Salzberg SL: TopHat2: Accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions. Genome Biol. 14:R362013. View Article : Google Scholar : PubMed/NCBI

22 

Wang L, Feng Z, Wang X, Wang X and Zhang X: DEGseq: An R package for identifying differentially expressed genes from RNA-seq data. Bioinformatics. 26:136–138. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Adnan M, Morton G and Hadi S: Analysis of rpoS and bolA gene expression under various stress-induced environments in planktonic and biofilm phase using 2(−ΔΔCT) method. Mol Cell Biochem. 357:275–282. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Vo JN, Cieslik M, Zhang Y, Shukla S, Xiao L, Zhang Y, Wu YM, Dhanasekaran SM, Engelke CG, Cao X, et al: The landscape of circular RNA in cancer. Cell. 176:869–881.e13. 2019. View Article : Google Scholar : PubMed/NCBI

25 

Dahl M, Kristensen LS and Grønbæk K: Long non-coding RNAs guide the fine-tuning of gene regulation in B-cell development and malignancy. Int J Mol Sci. 19:24572018. View Article : Google Scholar

26 

Hansen TB, Jensen TI, Clausen BH, Bramsen JB, Finsen B, Damgaard CK and Kjems J: Natural RNA circles function as efficient microRNA sponges. Nature. 495:384–388. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, et al: Circular RNAs are a large class of animal RNAs with regulatory potency. Nature. 495:333–338. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Locatelli F, Schrappe M, Bernardo ME and Rutella S: How I treat relapsed childhood acute lymphoblastic leukemia. Blood. 120:2807–2816. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Bhojwani D and Pui CH: Relapsed childhood acute lymphoblastic leukaemia. Lancet Oncol. 14:e205–e217. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Hunger SP, Lu X, Devidas M, Camitta BM, Gaynon PS, Winick NJ, Reaman GH and Carroll WL: Improved survival for children and adolescents with acute lymphoblastic leukemia between 1990 and 2005: A report from the children's oncology group. J Clin Oncol. 30:1663–1669. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Jing W and Li J: Identification of biomarkers for the prediction of relapse free survival in pediatric B precursor acute lymphoblastic leukemia. Oncol Rep. 41:659–667. 2019.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhou B, Zhong L, Tian L, Zhang Y, Wang R, He Q and Zhao Y: Identification of two downregulated circRNAs in patients with acute B‑lymphocytic leukemia. Oncol Lett 23: 40, 2022.
APA
Zhou, B., Zhong, L., Tian, L., Zhang, Y., Wang, R., He, Q., & Zhao, Y. (2022). Identification of two downregulated circRNAs in patients with acute B‑lymphocytic leukemia. Oncology Letters, 23, 40. https://doi.org/10.3892/ol.2021.13158
MLA
Zhou, B., Zhong, L., Tian, L., Zhang, Y., Wang, R., He, Q., Zhao, Y."Identification of two downregulated circRNAs in patients with acute B‑lymphocytic leukemia". Oncology Letters 23.1 (2022): 40.
Chicago
Zhou, B., Zhong, L., Tian, L., Zhang, Y., Wang, R., He, Q., Zhao, Y."Identification of two downregulated circRNAs in patients with acute B‑lymphocytic leukemia". Oncology Letters 23, no. 1 (2022): 40. https://doi.org/10.3892/ol.2021.13158
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou B, Zhong L, Tian L, Zhang Y, Wang R, He Q and Zhao Y: Identification of two downregulated circRNAs in patients with acute B‑lymphocytic leukemia. Oncol Lett 23: 40, 2022.
APA
Zhou, B., Zhong, L., Tian, L., Zhang, Y., Wang, R., He, Q., & Zhao, Y. (2022). Identification of two downregulated circRNAs in patients with acute B‑lymphocytic leukemia. Oncology Letters, 23, 40. https://doi.org/10.3892/ol.2021.13158
MLA
Zhou, B., Zhong, L., Tian, L., Zhang, Y., Wang, R., He, Q., Zhao, Y."Identification of two downregulated circRNAs in patients with acute B‑lymphocytic leukemia". Oncology Letters 23.1 (2022): 40.
Chicago
Zhou, B., Zhong, L., Tian, L., Zhang, Y., Wang, R., He, Q., Zhao, Y."Identification of two downregulated circRNAs in patients with acute B‑lymphocytic leukemia". Oncology Letters 23, no. 1 (2022): 40. https://doi.org/10.3892/ol.2021.13158
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team