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Article Open Access

Toxoplasma gondii causes changes in the host's expression of cancer‑associated miRNAs

  • Authors:
    • Lin Wang
    • Ning Wang
    • Ying Hui Zhao
    • Gang Lu
  • View Affiliations / Copyright

    Affiliations: Department of Epilepsy Center, Ji Nan Children's Hospital, Jinan, Shandong 250022, P.R. China, Department of Clinical Laboratory, Qingdao Third People's Hospital, Qingdao, Shandong 266041, P.R. China, Department of Pathogen Biology, School of Basic Medical Sciences, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong 250062, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 149
    |
    Published online on: March 15, 2022
       https://doi.org/10.3892/ol.2022.13267
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Abstract

Throughout the world, numerous individuals are infected with Toxoplasma gondii, which may improve immunity against cancer. Furthermore, microRNAs (miRs) may be differentially expressed in the host upon infection with T. gondii. In the present study, RNA‑sequencing analysis and reverse transcription‑quantitative PCR revealed that miR‑429‑3p, miR‑145a‑5p, miR‑211‑5p, miR‑31‑3p and miR‑135a‑5p were determined to be downregulated, while miR‑21a‑3p, miR‑135b‑5p, miR‑210‑5p and miR‑146‑3p were upregulated in mice post‑infection with T. gondii. Antitumor genes [TNF receptor superfamily member 11b, large tumor suppressor kinase (Lats)2 and Lats1] were identified as targets of miR‑429‑3p, miR‑145a‑5p, miR‑211‑5p, miR‑31‑3p and miR‑135a‑5p with a luciferase reporter assay. In addition, the protein levels of Lats2 and Lats1 were detected to be higher in T. gondii‑infected mice than in the control group. Therefore, these results provide favorable evidence for the suppression of cancer upon T. gondii infection and may give novel ideas for the treatment of tumors.
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Copy and paste a formatted citation
Spandidos Publications style
Wang L, Wang N, Zhao YH and Lu G: <em>Toxoplasma gondii</em> causes changes in the host's expression of cancer‑associated miRNAs. Oncol Lett 23: 149, 2022.
APA
Wang, L., Wang, N., Zhao, Y.H., & Lu, G. (2022). <em>Toxoplasma gondii</em> causes changes in the host's expression of cancer‑associated miRNAs. Oncology Letters, 23, 149. https://doi.org/10.3892/ol.2022.13267
MLA
Wang, L., Wang, N., Zhao, Y. H., Lu, G."<em>Toxoplasma gondii</em> causes changes in the host's expression of cancer‑associated miRNAs". Oncology Letters 23.5 (2022): 149.
Chicago
Wang, L., Wang, N., Zhao, Y. H., Lu, G."<em>Toxoplasma gondii</em> causes changes in the host's expression of cancer‑associated miRNAs". Oncology Letters 23, no. 5 (2022): 149. https://doi.org/10.3892/ol.2022.13267
Copy and paste a formatted citation
x
Spandidos Publications style
Wang L, Wang N, Zhao YH and Lu G: <em>Toxoplasma gondii</em> causes changes in the host's expression of cancer‑associated miRNAs. Oncol Lett 23: 149, 2022.
APA
Wang, L., Wang, N., Zhao, Y.H., & Lu, G. (2022). <em>Toxoplasma gondii</em> causes changes in the host's expression of cancer‑associated miRNAs. Oncology Letters, 23, 149. https://doi.org/10.3892/ol.2022.13267
MLA
Wang, L., Wang, N., Zhao, Y. H., Lu, G."<em>Toxoplasma gondii</em> causes changes in the host's expression of cancer‑associated miRNAs". Oncology Letters 23.5 (2022): 149.
Chicago
Wang, L., Wang, N., Zhao, Y. H., Lu, G."<em>Toxoplasma gondii</em> causes changes in the host's expression of cancer‑associated miRNAs". Oncology Letters 23, no. 5 (2022): 149. https://doi.org/10.3892/ol.2022.13267
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