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Article Open Access

High postoperative carcinoembryonic antigen as an indicator of high‑risk stage II colon cancer

  • Authors:
    • Yoshihiro Morimoto
    • Hidekazu Takahashi
    • Asami Arita
    • Hiroaki Itakura
    • Makoto Fujii
    • Yuki Sekido
    • Tsuyoshi Hata
    • Shiki Fujino
    • Takayuki Ogino
    • Norikatsu Miyoshi
    • Mamoru Uemura
    • Chu Matsuda
    • Hirofumi Yamamoto
    • Tsunekazu Mizushima
    • Yuichiro Doki
    • Hidetoshi Eguchi
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita, Osaka 565‑0871, Japan, Department of Mathematical Health Science, Graduate School of Medicine, Osaka University, Suita, Osaka 565‑0871, Japan
    Copyright: © Morimoto et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 167
    |
    Published online on: March 30, 2022
       https://doi.org/10.3892/ol.2022.13287
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Abstract

Postoperative carcinoembryonic antigen (post‑CEA) has recently been reported to be a reliable prognostic factor for colon cancer. However, most clinicians decide whether or not to conduct adjuvant chemotherapy (AC) for stage II colon cancer according to major guidelines, which do not include post‑CEA in their high‑risk criteria. The present study aimed to assess post‑CEA in stage II colon cancer for which the significance of AC is unknown. The present study analyzed 199 consecutive patients with stage II colon cancer who underwent curative surgery between January 2007 and December 2016. The CEA value was considered high when it was ≥5.0 ng/ml. The prognostic value of high post‑CEA values was assessed. Overall, 19 patients exhibited high post‑CEA levels. Kaplan‑Meier survival curve analysis demonstrated that patients with high post‑CEA levels had significantly worse relapse‑free survival (RFS) and overall survival (OS) than those with normal post‑CEA [RFS, 63.5 (high post‑CEA) vs. 88.0% (normal post‑CEA), P=0.003; OS, 76.5 (high post‑CEA) vs. 96.8% (normal post‑CEA), P<0.001]. Multivariate analysis demonstrated that high post‑CEA remained a significant independent risk factor for worse RFS [hazard ratio (HR), 3.98; P=0.006]. The same was also demonstrated for patients without AC (HR, 5.43; P=0.008). To the best of our knowledge, the present study was the first to demonstrate that high post‑CEA levels may be an indicator of high‑risk stage II colon cancer, even for patients without AC. These results highlight the need for a multicenter prospective study.
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Copy and paste a formatted citation
Spandidos Publications style
Morimoto Y, Takahashi H, Arita A, Itakura H, Fujii M, Sekido Y, Hata T, Fujino S, Ogino T, Miyoshi N, Miyoshi N, et al: High postoperative carcinoembryonic antigen as an indicator of high‑risk stage II colon cancer. Oncol Lett 23: 167, 2022.
APA
Morimoto, Y., Takahashi, H., Arita, A., Itakura, H., Fujii, M., Sekido, Y. ... Eguchi, H. (2022). High postoperative carcinoembryonic antigen as an indicator of high‑risk stage II colon cancer. Oncology Letters, 23, 167. https://doi.org/10.3892/ol.2022.13287
MLA
Morimoto, Y., Takahashi, H., Arita, A., Itakura, H., Fujii, M., Sekido, Y., Hata, T., Fujino, S., Ogino, T., Miyoshi, N., Uemura, M., Matsuda, C., Yamamoto, H., Mizushima, T., Doki, Y., Eguchi, H."High postoperative carcinoembryonic antigen as an indicator of high‑risk stage II colon cancer". Oncology Letters 23.5 (2022): 167.
Chicago
Morimoto, Y., Takahashi, H., Arita, A., Itakura, H., Fujii, M., Sekido, Y., Hata, T., Fujino, S., Ogino, T., Miyoshi, N., Uemura, M., Matsuda, C., Yamamoto, H., Mizushima, T., Doki, Y., Eguchi, H."High postoperative carcinoembryonic antigen as an indicator of high‑risk stage II colon cancer". Oncology Letters 23, no. 5 (2022): 167. https://doi.org/10.3892/ol.2022.13287
Copy and paste a formatted citation
x
Spandidos Publications style
Morimoto Y, Takahashi H, Arita A, Itakura H, Fujii M, Sekido Y, Hata T, Fujino S, Ogino T, Miyoshi N, Miyoshi N, et al: High postoperative carcinoembryonic antigen as an indicator of high‑risk stage II colon cancer. Oncol Lett 23: 167, 2022.
APA
Morimoto, Y., Takahashi, H., Arita, A., Itakura, H., Fujii, M., Sekido, Y. ... Eguchi, H. (2022). High postoperative carcinoembryonic antigen as an indicator of high‑risk stage II colon cancer. Oncology Letters, 23, 167. https://doi.org/10.3892/ol.2022.13287
MLA
Morimoto, Y., Takahashi, H., Arita, A., Itakura, H., Fujii, M., Sekido, Y., Hata, T., Fujino, S., Ogino, T., Miyoshi, N., Uemura, M., Matsuda, C., Yamamoto, H., Mizushima, T., Doki, Y., Eguchi, H."High postoperative carcinoembryonic antigen as an indicator of high‑risk stage II colon cancer". Oncology Letters 23.5 (2022): 167.
Chicago
Morimoto, Y., Takahashi, H., Arita, A., Itakura, H., Fujii, M., Sekido, Y., Hata, T., Fujino, S., Ogino, T., Miyoshi, N., Uemura, M., Matsuda, C., Yamamoto, H., Mizushima, T., Doki, Y., Eguchi, H."High postoperative carcinoembryonic antigen as an indicator of high‑risk stage II colon cancer". Oncology Letters 23, no. 5 (2022): 167. https://doi.org/10.3892/ol.2022.13287
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