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Epigenetic editing and tumor‑dependent immunosuppressive signaling in head and neck malignancies (Review)

  • Authors:
    • Spyridon Gougousis
    • Savvas Petanidis
    • Alexandros Poutoglidis
    • Nikolaos Tsetsos
    • Paraskevas Vrochidis
    • Ioannis Skoumpas
    • Nektarios Argyriou
    • Theodora Katopodi
    • Kalliopi Domvri
  • View Affiliations / Copyright

    Affiliations: Ear Nose Throat Department, General Hospital of Thessaloniki ‘G. Papanikolaou’, Thessaloniki GR‑57010, Greece, Department of Pulmonology, I.M. Sechenov First Moscow State Medical University, Moscow 119992, Russian Federation, Ear Nose Throat Department, General Hospital of Goumenissa, Kilkis GR‑61100, Greece, Ear Nose Throat Department, General Hospital of Katerini, Katerini GR‑60100, Greece, Ear Nose Throat Department, General Hospital of Thessaloniki ‘G. Gennimatas’, Thessaloniki GR‑54635, Greece, Department of Medicine, Laboratory of Medical Biology and Genetics, Aristotle University of Thessaloniki, Thessaloniki GR‑54124, Greece, Pulmonary Department, General Hospital of Thessaloniki ‘G. Papanikolaou’, Aristotle University of Thessaloniki, Thessaloniki GR‑57010, Greece
    Copyright: © Gougousis et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 196
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    Published online on: May 4, 2022
       https://doi.org/10.3892/ol.2022.13317
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Abstract

Head and neck cancer (HNC) comprises a heterogeneous variety of malignant tumors, characterized by a relatively high tumor mutation burden. Previous data have revealed that immune system dysfunction appears to serve a key role in the development and progression of HNC and established immunosuppression is vital for evading the host immune response. Despite progress in chemotherapy and radiotherapy, the survival rate of patients with HNC is still low. Therefore, the present review discusses the development of novel immunotherapy approaches based on the various immune cell signaling routes that trigger drug resistance and immunosuppression. Additionally, the present review discusses the epigenetic alterations, including DNA methylation, histone modifications, chromatin remodeling and non‑coding RNAs that drive and support HNC progression. Furthermore, the role of cancer‑associated fibroblasts, tumor macrophages and myeloid cells in tumor‑related immunosuppression are considered. Specifically, the molecular immune‑related mechanisms in the tumor microenvironment, which lead to decreased drug sensitivity and tumor relapse, and strategies for reversing drug resistance and targeting immunosuppressive tumor networks are discussed. Deciphering these molecular mechanisms is essential for preclinical and clinical investigations in order to enhance therapeutic efficacy. Furthermore, an improved understanding of these immune cell signaling pathways that drive immune surveillance, immune‑driven inflammation and tumor‑related immunosuppression is necessary for future personalized HNC‑based therapeutic approaches.
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Copy and paste a formatted citation
Spandidos Publications style
Gougousis S, Petanidis S, Poutoglidis A, Tsetsos N, Vrochidis P, Skoumpas I, Argyriou N, Katopodi T and Domvri K: Epigenetic editing and tumor‑dependent immunosuppressive signaling in head and neck malignancies (Review). Oncol Lett 23: 196, 2022.
APA
Gougousis, S., Petanidis, S., Poutoglidis, A., Tsetsos, N., Vrochidis, P., Skoumpas, I. ... Domvri, K. (2022). Epigenetic editing and tumor‑dependent immunosuppressive signaling in head and neck malignancies (Review). Oncology Letters, 23, 196. https://doi.org/10.3892/ol.2022.13317
MLA
Gougousis, S., Petanidis, S., Poutoglidis, A., Tsetsos, N., Vrochidis, P., Skoumpas, I., Argyriou, N., Katopodi, T., Domvri, K."Epigenetic editing and tumor‑dependent immunosuppressive signaling in head and neck malignancies (Review)". Oncology Letters 23.6 (2022): 196.
Chicago
Gougousis, S., Petanidis, S., Poutoglidis, A., Tsetsos, N., Vrochidis, P., Skoumpas, I., Argyriou, N., Katopodi, T., Domvri, K."Epigenetic editing and tumor‑dependent immunosuppressive signaling in head and neck malignancies (Review)". Oncology Letters 23, no. 6 (2022): 196. https://doi.org/10.3892/ol.2022.13317
Copy and paste a formatted citation
x
Spandidos Publications style
Gougousis S, Petanidis S, Poutoglidis A, Tsetsos N, Vrochidis P, Skoumpas I, Argyriou N, Katopodi T and Domvri K: Epigenetic editing and tumor‑dependent immunosuppressive signaling in head and neck malignancies (Review). Oncol Lett 23: 196, 2022.
APA
Gougousis, S., Petanidis, S., Poutoglidis, A., Tsetsos, N., Vrochidis, P., Skoumpas, I. ... Domvri, K. (2022). Epigenetic editing and tumor‑dependent immunosuppressive signaling in head and neck malignancies (Review). Oncology Letters, 23, 196. https://doi.org/10.3892/ol.2022.13317
MLA
Gougousis, S., Petanidis, S., Poutoglidis, A., Tsetsos, N., Vrochidis, P., Skoumpas, I., Argyriou, N., Katopodi, T., Domvri, K."Epigenetic editing and tumor‑dependent immunosuppressive signaling in head and neck malignancies (Review)". Oncology Letters 23.6 (2022): 196.
Chicago
Gougousis, S., Petanidis, S., Poutoglidis, A., Tsetsos, N., Vrochidis, P., Skoumpas, I., Argyriou, N., Katopodi, T., Domvri, K."Epigenetic editing and tumor‑dependent immunosuppressive signaling in head and neck malignancies (Review)". Oncology Letters 23, no. 6 (2022): 196. https://doi.org/10.3892/ol.2022.13317
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