Open Access

Role of von Willebrand factor in the angiogenesis of lung adenocarcinoma (Review)

  • Authors:
    • Xin Li
    • Zhong Lu
  • View Affiliations

  • Published online on: May 5, 2022     https://doi.org/10.3892/ol.2022.13319
  • Article Number: 198
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Lung adenocarcinoma (LUAD) has a high morbidity and mortality rate worldwide, and its growth and metastasis require angiogenesis. The density of microvessels in LUAD is positively correlated with metastasis and recurrence. Von Willebrand factor (VWF) is a multifunctional glycoprotein in blood plasma. Recent evidence shows that VWF inhibits angiogenesis through regulation of angiopoietin‑2 (Ang‑2) and integrin αvβ3. LUAD patients exhibit an increase in the plasma VWF/ADAMTS‑13 ratio. Gene expression profiles of LUAD tissues indicate that VWF is differentially expressed in LUAD tissues compared to normal tissues. GATA binding protein 3 (GATA3) transcription factor may mediate VWF expression in LUAD. In this review, we summarize the role of VWF in LUAD and its regulatory mechanisms. We also discuss the potential of VWF as a diagnostic indicator and therapeutic target of LUAD.

Related Articles

Journal Cover

June-2022
Volume 23 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Li X and Li X: Role of von Willebrand factor in the angiogenesis of lung adenocarcinoma (Review). Oncol Lett 23: 198, 2022
APA
Li, X., & Li, X. (2022). Role of von Willebrand factor in the angiogenesis of lung adenocarcinoma (Review). Oncology Letters, 23, 198. https://doi.org/10.3892/ol.2022.13319
MLA
Li, X., Lu, Z."Role of von Willebrand factor in the angiogenesis of lung adenocarcinoma (Review)". Oncology Letters 23.6 (2022): 198.
Chicago
Li, X., Lu, Z."Role of von Willebrand factor in the angiogenesis of lung adenocarcinoma (Review)". Oncology Letters 23, no. 6 (2022): 198. https://doi.org/10.3892/ol.2022.13319