Malignant transformation of Warthin's tumor into squamous cell carcinoma: A case report

Shou,Leyi; Chen,Xiaodan; Yang,Junjie; Jiang,Yiqian

doi:10.3892/ol.2022.13322

July-2022 Volume 24 Issue 1

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July-2022 Volume 24 Issue 1

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Case Report Open Access

Malignant transformation of Warthin's tumor into squamous cell carcinoma: A case report

Authors:
- Leyi Shou
- Xiaodan Chen
- Junjie Yang
- Yiqian Jiang
View Affiliations / Copyright

Affiliations: Department of Pathology, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou, Zhejiang 311200, P.R. China, Department of Pathology, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou, Zhejiang 311200, P.R. China, Department of Radiotherapy, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou, Zhejiang 311200, P.R. China

Copyright: © Shou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Article Number: 201
|
Published online on: May 12, 2022

https://doi.org/10.3892/ol.2022.13322
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Abstract

Malignant transformation of Warthin's tumor into squamous cell carcinoma is rare. The present study reported on a case of a 67‑year‑old male patient diagnosed with this condition. Microscopically, the tumor was mainly composed of squamous cell carcinoma and lymphoid stroma. Furthermore, the squamous cell carcinoma cells were arranged in a solid flake‑like, papillary and cystic shape. Local bleeding was observed in the mass and a large number of lymphoid stroma‑associated centers were observed between the cancer cells. The expression of cytokeratin (CK)5/6, P40, CK7, CK18, CK8 and MutS protein homolog 2 was detected by immunohistochemistry, in addition to Epstein‑Barr encoding region in situ hybridization (‑), Ki‑67 (epithelial 25% +) and p53 (wild‑type). The diagnosis of malignant transformation of Warthin's tumor into squamous cell carcinoma depends on the histopathology. The microscopic diagnosis is based on the dynamic process of scaling, atypical hyperplasia and cancerization of the eosinophilic columnar epithelium. Of note, it is also necessary to differentiate it from cervical malignant tumors such as lymphoepithelial carcinoma. The main clinical treatment is surgical resection with negative margins.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Malignant transformation of Warthin's tumor into squamous cell carcinoma: A case report

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Abstract

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