Malignant transformation of Warthin's tumor into squamous cell carcinoma: A case report

Shou,Leyi; Chen,Xiaodan; Yang,Junjie; Jiang,Yiqian

doi:10.3892/ol.2022.13322

Malignant transformation of Warthin's tumor into squamous cell carcinoma: A case report

Authors:
- Leyi Shou
- Xiaodan Chen
- Junjie Yang
- Yiqian Jiang
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Affiliations: Department of Pathology, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou, Zhejiang 311200, P.R. China, Department of Pathology, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou, Zhejiang 311200, P.R. China, Department of Radiotherapy, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou, Zhejiang 311200, P.R. China
Published online on: May 12, 2022 https://doi.org/10.3892/ol.2022.13322
Article Number: 201
Copyright: © Shou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Malignant transformation of Warthin's tumor into squamous cell carcinoma is rare. The present study reported on a case of a 67‑year‑old male patient diagnosed with this condition. Microscopically, the tumor was mainly composed of squamous cell carcinoma and lymphoid stroma. Furthermore, the squamous cell carcinoma cells were arranged in a solid flake‑like, papillary and cystic shape. Local bleeding was observed in the mass and a large number of lymphoid stroma‑associated centers were observed between the cancer cells. The expression of cytokeratin (CK)5/6, P40, CK7, CK18, CK8 and MutS protein homolog 2 was detected by immunohistochemistry, in addition to Epstein‑Barr encoding region in situ hybridization (‑), Ki‑67 (epithelial 25% +) and p53 (wild‑type). The diagnosis of malignant transformation of Warthin's tumor into squamous cell carcinoma depends on the histopathology. The microscopic diagnosis is based on the dynamic process of scaling, atypical hyperplasia and cancerization of the eosinophilic columnar epithelium. Of note, it is also necessary to differentiate it from cervical malignant tumors such as lymphoepithelial carcinoma. The main clinical treatment is surgical resection with negative margins.

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