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High expression of 14‑3‑3ơ indicates poor prognosis and progression of lung adenocarcinoma

  • Authors:
    • Junfei Feng
    • Jing Leng
    • Changdi Zhao
    • Jie Guo
    • Yongbing Chen
    • Haifeng Li
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory and Critical Care Medicine, The Third People's Hospital of Yunnan Province, Kunming, Yunnan 650011, P.R. China, Department of Respiratory Medicine, People's Hospital of Beilun District, Ningbo, Zhejiang 315826, P.R. China
    Copyright: © Feng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 203
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    Published online on: May 12, 2022
       https://doi.org/10.3892/ol.2022.13323
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Abstract

Lung adenocarcinoma (LUAD) is one of the leading causes of cancer‑related death worldwide. 14‑3‑3ơ is an intracellular phosphoserine‑binding protein that has been proposed to be involved in tumorigenesis. However, the biofunctional role of 14‑3‑3ơ and its clinicopathological/prognostic significance in LUAD have remained elusive. In the present study, western blot and immunohistochemical analyses of cancer tissues/cells and the corresponding normal controls were performed to verify that 14‑3‑3ơ was upregulated in LUAD. Univariate and multivariate logistic regression analysis indicated that high expression of 14‑3‑3ơ predicted poor overall survival and progression‑free survival of patients with LUAD. Furthermore, in vivo and in vitro experiments demonstrated that overexpression of 14‑3‑3ơ markedly promoted cell proliferation, colony formation, anchorage‑independent growth and tumor growth, whereas 14‑3‑3ơ depletion produced the opposite effects. Of note, 14‑3‑3ơ was identified as an independent prognostic factor for patients with LUAD. Collectively, the present results revealed that high expression of 14‑3‑3ơ may serve as an independent biomarker, contributing to poor prognosis and progression of LUAD.
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Copy and paste a formatted citation
Spandidos Publications style
Feng J, Leng J, Zhao C, Guo J, Chen Y and Li H: High expression of 14‑3‑3ơ indicates poor prognosis and progression of lung adenocarcinoma. Oncol Lett 24: 203, 2022.
APA
Feng, J., Leng, J., Zhao, C., Guo, J., Chen, Y., & Li, H. (2022). High expression of 14‑3‑3ơ indicates poor prognosis and progression of lung adenocarcinoma. Oncology Letters, 24, 203. https://doi.org/10.3892/ol.2022.13323
MLA
Feng, J., Leng, J., Zhao, C., Guo, J., Chen, Y., Li, H."High expression of 14‑3‑3ơ indicates poor prognosis and progression of lung adenocarcinoma". Oncology Letters 24.1 (2022): 203.
Chicago
Feng, J., Leng, J., Zhao, C., Guo, J., Chen, Y., Li, H."High expression of 14‑3‑3ơ indicates poor prognosis and progression of lung adenocarcinoma". Oncology Letters 24, no. 1 (2022): 203. https://doi.org/10.3892/ol.2022.13323
Copy and paste a formatted citation
x
Spandidos Publications style
Feng J, Leng J, Zhao C, Guo J, Chen Y and Li H: High expression of 14‑3‑3ơ indicates poor prognosis and progression of lung adenocarcinoma. Oncol Lett 24: 203, 2022.
APA
Feng, J., Leng, J., Zhao, C., Guo, J., Chen, Y., & Li, H. (2022). High expression of 14‑3‑3ơ indicates poor prognosis and progression of lung adenocarcinoma. Oncology Letters, 24, 203. https://doi.org/10.3892/ol.2022.13323
MLA
Feng, J., Leng, J., Zhao, C., Guo, J., Chen, Y., Li, H."High expression of 14‑3‑3ơ indicates poor prognosis and progression of lung adenocarcinoma". Oncology Letters 24.1 (2022): 203.
Chicago
Feng, J., Leng, J., Zhao, C., Guo, J., Chen, Y., Li, H."High expression of 14‑3‑3ơ indicates poor prognosis and progression of lung adenocarcinoma". Oncology Letters 24, no. 1 (2022): 203. https://doi.org/10.3892/ol.2022.13323
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