Open Access

High expression of 14‑3‑3ơ indicates poor prognosis and progression of lung adenocarcinoma

  • Authors:
    • Junfei Feng
    • Jing Leng
    • Changdi Zhao
    • Jie Guo
    • Yongbing Chen
    • Haifeng Li
  • View Affiliations

  • Published online on: May 12, 2022     https://doi.org/10.3892/ol.2022.13323
  • Article Number: 203
  • Copyright: © Feng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Lung adenocarcinoma (LUAD) is one of the leading causes of cancer‑related death worldwide. 14‑3‑3ơ is an intracellular phosphoserine‑binding protein that has been proposed to be involved in tumorigenesis. However, the biofunctional role of 14‑3‑3ơ and its clinicopathological/prognostic significance in LUAD have remained elusive. In the present study, western blot and immunohistochemical analyses of cancer tissues/cells and the corresponding normal controls were performed to verify that 14‑3‑3ơ was upregulated in LUAD. Univariate and multivariate logistic regression analysis indicated that high expression of 14‑3‑3ơ predicted poor overall survival and progression‑free survival of patients with LUAD. Furthermore, in vivo and in vitro experiments demonstrated that overexpression of 14‑3‑3ơ markedly promoted cell proliferation, colony formation, anchorage‑independent growth and tumor growth, whereas 14‑3‑3ơ depletion produced the opposite effects. Of note, 14‑3‑3ơ was identified as an independent prognostic factor for patients with LUAD. Collectively, the present results revealed that high expression of 14‑3‑3ơ may serve as an independent biomarker, contributing to poor prognosis and progression of LUAD.
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July-2022
Volume 24 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Feng J, Leng J, Zhao C, Guo J, Chen Y and Li H: High expression of 14‑3‑3ơ indicates poor prognosis and progression of lung adenocarcinoma. Oncol Lett 24: 203, 2022
APA
Feng, J., Leng, J., Zhao, C., Guo, J., Chen, Y., & Li, H. (2022). High expression of 14‑3‑3ơ indicates poor prognosis and progression of lung adenocarcinoma. Oncology Letters, 24, 203. https://doi.org/10.3892/ol.2022.13323
MLA
Feng, J., Leng, J., Zhao, C., Guo, J., Chen, Y., Li, H."High expression of 14‑3‑3ơ indicates poor prognosis and progression of lung adenocarcinoma". Oncology Letters 24.1 (2022): 203.
Chicago
Feng, J., Leng, J., Zhao, C., Guo, J., Chen, Y., Li, H."High expression of 14‑3‑3ơ indicates poor prognosis and progression of lung adenocarcinoma". Oncology Letters 24, no. 1 (2022): 203. https://doi.org/10.3892/ol.2022.13323