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Review Open Access

Metformin: A promising drug for human cancers (Review)

  • Authors:
    • Hongnian Wu
    • Dan Huang
    • Hong Zhou
    • Xueqin Sima
    • Zhe Wu
    • Yanling Sun
    • Long Wang
    • Ying Ruan
    • Qian Wu
    • Feng Wu
    • Tonghui She
    • Ying Chu
    • Qizhi Huang
    • Zhifeng Ning
    • Hao Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Human Anatomy, Basic Medicine School, Hubei University of Science and Technology, Xianning, Hubei 437100, P.R. China, Department of Burn and Plastic Surgery, Enshi State Central Hospital, Enshi, Hubei 445099, P.R. China, Department of Histology and Embryology, Hubei University of Science and Technology, Xianning, Hubei 437100, P.R. China, Department of Microbiology, Basic Medicine School, Hubei University of Science and Technology, Xianning, Hubei 437100, P.R. China, Department of Dermatology, Clinical Medicine School, Hubei University of Science and Technology, Xianning, Hubei 437100, P.R. China, Nursing School, Hubei University of Science and Technology, Xianning, Hubei 437100, P.R. China, Stomatology and Optometry School, Hubei University of Science and Technology, Xianning, Hubei 437100, P.R. China, Department of Pathology, Basic Medicine School, Hubei University of Science and Technology, Xianning, Hubei 437100, P.R. China, Department of Clinical Lab, Second Affiliated Hospital, Hubei University of Science and Technology, Xianning, Hubei 437100, P.R. China, Department of Human Anatomy, Basic Medicine School, Hubei University of Science and Technology, Xianning, Hubei 437100, P.R. China, Institute of Precision Cancer Medicine and Pathology, Department of Pathology, Jinan University Medical College, Guangzhou, Guangdong 510630, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 204
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    Published online on: May 12, 2022
       https://doi.org/10.3892/ol.2022.13325
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Abstract

Small‑molecule chemical drugs are of great significance for tumor‑targeted and individualized therapies. However, the development of new small‑molecule drugs, from basic experimental research and clinical trials to final application in clinical practice, is a long process that has a high cost. It takes at least 5 years for most drugs to be developed in the laboratory to prove their effectiveness and safety. Compared with the development of new drugs, repurposing traditional non‑tumor drugs can be a shortcut. Metformin is a good model for a new use of an old drug. In recent years, the antitumor efficacy of metformin has attracted much attention. Epidemiological data and in vivo, and in vitro experiments have shown that metformin can reduce the incidence of cancer in patients with diabetes and has a strong antagonistic effect on metabolism‑related tumors. Recent studies have shown that metformin can induce autophagy in esophageal cancer cells, mainly by inhibiting inflammatory signaling pathways. In recent years, studies have shown that the antitumor functions and mechanisms of metformin are multifaceted. The present study aims to review the application of metformin in tumor prevention and treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Wu H, Huang D, Zhou H, Sima X, Wu Z, Sun Y, Wang L, Ruan Y, Wu Q, Wu F, Wu F, et al: Metformin: A promising drug for human cancers (Review). Oncol Lett 24: 204, 2022.
APA
Wu, H., Huang, D., Zhou, H., Sima, X., Wu, Z., Sun, Y. ... Zhang, H. (2022). Metformin: A promising drug for human cancers (Review). Oncology Letters, 24, 204. https://doi.org/10.3892/ol.2022.13325
MLA
Wu, H., Huang, D., Zhou, H., Sima, X., Wu, Z., Sun, Y., Wang, L., Ruan, Y., Wu, Q., Wu, F., She, T., Chu, Y., Huang, Q., Ning, Z., Zhang, H."Metformin: A promising drug for human cancers (Review)". Oncology Letters 24.1 (2022): 204.
Chicago
Wu, H., Huang, D., Zhou, H., Sima, X., Wu, Z., Sun, Y., Wang, L., Ruan, Y., Wu, Q., Wu, F., She, T., Chu, Y., Huang, Q., Ning, Z., Zhang, H."Metformin: A promising drug for human cancers (Review)". Oncology Letters 24, no. 1 (2022): 204. https://doi.org/10.3892/ol.2022.13325
Copy and paste a formatted citation
x
Spandidos Publications style
Wu H, Huang D, Zhou H, Sima X, Wu Z, Sun Y, Wang L, Ruan Y, Wu Q, Wu F, Wu F, et al: Metformin: A promising drug for human cancers (Review). Oncol Lett 24: 204, 2022.
APA
Wu, H., Huang, D., Zhou, H., Sima, X., Wu, Z., Sun, Y. ... Zhang, H. (2022). Metformin: A promising drug for human cancers (Review). Oncology Letters, 24, 204. https://doi.org/10.3892/ol.2022.13325
MLA
Wu, H., Huang, D., Zhou, H., Sima, X., Wu, Z., Sun, Y., Wang, L., Ruan, Y., Wu, Q., Wu, F., She, T., Chu, Y., Huang, Q., Ning, Z., Zhang, H."Metformin: A promising drug for human cancers (Review)". Oncology Letters 24.1 (2022): 204.
Chicago
Wu, H., Huang, D., Zhou, H., Sima, X., Wu, Z., Sun, Y., Wang, L., Ruan, Y., Wu, Q., Wu, F., She, T., Chu, Y., Huang, Q., Ning, Z., Zhang, H."Metformin: A promising drug for human cancers (Review)". Oncology Letters 24, no. 1 (2022): 204. https://doi.org/10.3892/ol.2022.13325
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