Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
July-2022 Volume 24 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2022 Volume 24 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

A retrospective study of parotid gland tumors at a single institution

  • Authors:
    • Shiori Suzuki
    • Nobuyuki Bandoh
    • Takashi Goto
    • Akinobu Kubota
    • Akihiro Uemura
    • Michihisa Kono
    • Ryosuke Sato
    • Ryuhei Takeda
    • Shota Sakaue
    • Tomomi Yamaguchi‑Isochi
    • Hiroshi Nishihara
    • Hidehiro Takei
    • Yasuaki Harabuchi
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology‑Head and Neck Surgery, Hokuto Hospital, Obihiro, Hokkaido 080‑0833, Japan, Department of Pathology and Genetics, Hokuto Hospital, Obihiro, Hokkaido 080‑0833, Japan, Genomics Unit, Keio Cancer Center, Keio University School of Medicine, Shinjukuku, Tokyo 160‑8582, Japan, Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA 71103, USA
    Copyright: © Suzuki et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 207
    |
    Published online on: May 13, 2022
       https://doi.org/10.3892/ol.2022.13328
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to analyze the clinical characteristics, surgical treatments and clinical outcome of patients with parotid gland tumors and to compare the results with those cited in the literature. A retrospective study was conducted in 140 patients (male, n=77; female, n=63) with parotid gland tumors who underwent parotidectomy at Hokuto Hospital Department of Otolaryngology‑Head and Neck Surgery (Obihiro, Japan) between April 2007 and December 2021. Of the 140 patients enrolled, 118 (84.3%) patients had benign tumors, including 63 (45%) patients with pleomorphic adenomas and 43 (30.7%) patients with Warthin tumors, and 22 patients (15.7%) had parotid carcinoma. Comparison of the three groups of patients with parotid gland tumors indicated that pack years as an indicator of smoking status were significantly higher in patients with Warthin tumors than in those with parotid carcinomas (P=0.011) or pleomorphic adenoma (P<0.001). Fine‑needle aspiration cytology (FNAC) was non‑diagnostic for only 6 (4.3%) of 140 patients. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of FNAC by both conventional smear and liquid‑based cytology (LBC) for parotid carcinomas were 70, 99, 93.3, 94.4 and 82.9%, respectively. Among the 22 patients with parotid carcinoma, extended total/total and superficial parotidectomy were performed in 10 (45%) and 11 (50%) cases, respectively. Total and selective neck dissection of the area from level II to I, II and III were performed in 6 (24%) and 7 (32%) patients, respectively. Postoperative radiotherapy (50 Gy) was performed in 15 (68%) patients. The overall survival (OS) and disease‑free survival (DFS) rates at 5 years were 51.5 and 76.4%, respectively. Univariate analysis revealed that age >65 years was significantly associated with poorer 5‑year OS (P<0.001) and DFS (P<0.001). Multivariate analysis revealed that an age of more than 65 years combined with high‑grade histologic malignancy was associated with worse DFS (P=0.02; hazard ratio, 3.628; 95% confidence interval, 1.283‑9.514). In conclusion, the clinical characteristics and treatment outcomes of parotid gland tumors were consistent with the results of previous reports. Smoking may be closely related to the pathogenesis of Warthin tumors. LBC potentially provides improved accuracy in FNAC.
View Figures

Figure 1

View References

1 

Seethala RR and Stenman G: Update from the 4th edition of the World Health Organization classification of head and neck tumours: Tumors of the salivary gland. Head Neck Pathol. 11:55–67. 2017. View Article : Google Scholar

2 

Suzuki M, Kawata R, Higashino M, Nishikawa S, Terada T, Haginomori SI, Kurisu Y and Hirose Y: Values of fine-needle aspiration cytology of parotid gland tumors: A review of 996 cases at a single institution. Head Neck. 41:358–365. 2019. View Article : Google Scholar : PubMed/NCBI

3 

Rarick JM, Wasman J and Michael CW: The utility of liquid-based cytology in salivary gland fine-needle aspirates: Experience of an academic institution. Acta Cytol. 58:552–562. 2014.

4 

Sood AJ, Houlton JJ, Nguyen SA and Gillespie MB: Facial nerve monitoring during parotidectomy: A systematic review and meta-analysis. Otolaryngol Head Neck Surg. 152:631–637. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Yamaguchi T, Akahane T, Harada O, Kato Y, Aimono E, Takei H, Tasaki T, Noguchi H, Nishihara H, Kamata H and Tanimoto A: Next-generation sequencing in residual liquid-based cytology specimens for cancer genome analysis. Diagn Cytopathol. 48:965–971. 2020. View Article : Google Scholar

6 

Kawata R, Kinoshita I, Omura S, Higashino M, Nishikawa S, Terada T, Haginomori SI, Kurisu Y, Hirose Y and Tochizawa T: Risk factors of postoperative facial palsy for benign parotid tumors: Outcome of 1,018 patients. Laryngoscope. 131:E2857–E2864. 2021. View Article : Google Scholar : PubMed/NCBI

7 

Iizuka K and Ishikawa K: Surgical techniques for benign parotid tumors: Segmental resection vs extracapsular lumpectomy. Acta Otolaryngol Suppl. 537:75–81. 1998.

8 

Witt RL: Minimally invasive surgery for parotid pleomorphic adenoma. Ear Nose Throat J. 84(308): 310–1. 2005. View Article : Google Scholar

9 

Numano Y, Ogawa T, Ishikawa T, Usubuchi H, Nakanome A, Ohkoshi A, Ishida E, Rokugo M and Katori Y: Parotid secretory carcinoma with high-grade transformation. Auris Nasus Larynx. 47:1043–1048. 2020. View Article : Google Scholar : PubMed/NCBI

10 

Li LJ, Li Y, Wen YM, Liu H and Zhao HW: Clinical analysis of salivary gland tumor cases in West China in past 50 years. Oral Oncol. 44:187–192. 2008. View Article : Google Scholar

11 

Grasl S, Kadletz L, Janik S, Riedl A, Erlacher B, Formanek M, Grasl MC and Erovic BM: Fine-needle aspiration cytology and intraoperative frozen section in parotid gland tumour surgery: A retrospective multicenter analysis of 417 cases. Clin Otolaryngol. 44:461–465. 2019. View Article : Google Scholar

12 

Gatta G, Guzzo M, Locati LD, McGurk M and Prott FJ: Major and minor salivary gland tumours. Crit Rev Oncol Hematol. 152:1029592020. View Article : Google Scholar

13 

Godballe C, Schultz JH, Krogdahl A, Moller-Grontved A and Johansen J: Parotid carcinoma: Impact of clinical factors on prognosis in a histologically revised series. Laryngoscope. 113:1411–1417. 2003. View Article : Google Scholar : PubMed/NCBI

14 

Pohar S, Gay H, Rosenbaum P, Klish D, Bogart J, Sagerman R, Hsu J and Kellman R: Malignant parotid tumors: Presentation, clinical/pathologic prognostic factors, and treatment outcomes. Int J Radiat Oncol Biol Phys. 61:112–118. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Nishikado A, Kawata R, Haginomori SI, Terada T, Higashino M, Kurisu Y and Hirose Y: A clinicopathological study of parotid carcinoma: 18-year review of 171 patients at a single institution. Int J Clin Oncol. 23:615–624. 2018. View Article : Google Scholar

16 

Terhaard C, Lubsen H, Tan B, Merkx T, van der Laan B, Baatenburg de Jong R, Manni H and Knegt P: Facial nerve function in carcinoma of the parotid gland. Eur J Cancer. 42:2744–2750. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Inaka Y, Kawata R, Haginomori SI, Terada T, Higashino M, Omura S and Kikuoka Y: Symptoms and signs of parotid tumors and their value for diagnosis and prognosis: A 20-year review at a single institution. Int J Clin Oncol. 26:1170–1178. 2021. View Article : Google Scholar

18 

de Oliveira FA, Duarte EC, Taveira CT, Maximo AA, de Aquino EC, Alencar Rde C and Vencio EF: Salivary gland tumor: A review of 599 cases in a Brazilian population. Head Neck Pathol. 3:271–275. 2009. View Article : Google Scholar

19 

Peter Klussmann J, Wittekindt C, Florian Preuss S, Al Attab A, Schroeder U and Guntinas-Lichius O: High risk for bilateral Warthin tumor in heavy smokers-review of 185 cases. Acta Otolaryngol. 126:1213–1217. 2006. View Article : Google Scholar

20 

Ethunandan M, Pratt CA, Morrison A, Anand R, Macpherson DW and Wilson AW: Multiple synchronous and metachronous neoplasms of the parotid gland: The Chichester experience. Br J Oral Maxillofac Surg. 44:397–401. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Kotwall CA: Smoking as an etiologic factor in the development of Warthin's tumor of the parotid gland. Am J Surg. 164:646–647. 1992. View Article : Google Scholar : PubMed/NCBI

22 

Sadetzki S, Oberman B, Mandelzweig L, Chetrit A, Ben-Tal T, Jarus-Hakak A, Duvdevani S, Cardis E and Wolf M: Smoking and risk of parotid gland tumors: A nationwide case-control study. Cancer. 112:1974–1982. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Allegra SR: Warthin's tumor: A hypersensitivity disease? Ultrastructural, light, and immunofluorescent study. Hum Pathol. 2:403–420. 1971. View Article : Google Scholar

24 

Lewis PD, Baxter P, Paul Griffiths A, Parry JM and Skibinski DO: Detection of damage to the mitochondrial genome in the oncocytic cells of Warthin's tumour. J Pathol. 191:274–281. 2000. View Article : Google Scholar

25 

Yu GY, Liu XB, Li ZL and Peng X: Smoking and the development of Warthin's tumour of the parotid gland. Br J Oral Maxillofac Surg. 36:183–185. 1998. View Article : Google Scholar : PubMed/NCBI

26 

de Ru JA, Plantinga RF, Majoor MH, van Benthem PP, Slootweg PJ, Peeters PH and Hordijk GJ: Warthin's tumour and smoking. B-ENT. 1:63–66. 2005.PubMed/NCBI

27 

Aguirre JM, Echebarria MA, Martinez-Conde R, Rodriguez C, Burgos JJ and Rivera JM: Warthin tumor. A new hypothesis concerning its development. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 85:60–63. 1998. View Article : Google Scholar : PubMed/NCBI

28 

Schmidt RL, Hall BJ, Wilson AR and Layfield LJ: A systematic review and meta-analysis of the diagnostic accuracy of fine-needle aspiration cytology for parotid gland lesions. Am J Clin Pathol. 136:45–59. 2011. View Article : Google Scholar

29 

Bandoh N, Goto T, Akahane T, Ohnuki N, Yamaguchi T, Kamada H, Harabuchi Y, Tanaka S and Nishihara H: Diagnostic value of liquid-based cytology with fine needle aspiration specimens for cervical lymphadenopathy. Diagn Cytopathol. 44:169–176. 2016. View Article : Google Scholar

30 

Que Hee CG and Perry CF: Fine-needle aspiration cytology of parotid tumours: Is it useful? ANZ J Surg. 71:345–348. 2001. View Article : Google Scholar : PubMed/NCBI

31 

Cohen EG, Patel SG, Lin O, Boyle JO, Kraus DH, Singh B, Wong RJ, Shah JP and Shaha AR: Fine-needle aspiration biopsy of salivary gland lesions in a selected patient population. Arch Otolaryngol Head Neck Surg. 130:773–778. 2004. View Article : Google Scholar : PubMed/NCBI

32 

Mallon DH, Kostalas M, MacPherson FJ, Parmar A, Drysdale A, Chisholm E and Sadek S: The diagnostic value of fine needle aspiration in parotid lumps. Ann R Coll Surg Engl. 95:258–262. 2013. View Article : Google Scholar

33 

Singh Nanda KD, Mehta A and Nanda J: Fine-needle aspiration cytology: A reliable tool in the diagnosis of salivary gland lesions. J Oral Pathol Med. 41:106–112. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Altin F, Alimoglu Y, Acikalin RM and Yasar H: Is fine needle aspiration biopsy reliable in the diagnosis of parotid tumors? Comparison of preoperative and postoperative results and the factors affecting accuracy. Braz J Otorhinolaryngol. 85:275–281. 2019. View Article : Google Scholar

35 

Stathopoulos P, Igoumenakis D and Smith WP: Partial superficial, superficial, and total parotidectomy in the management of benign parotid gland tumors: A 10-year prospective study of 205 patients. J Oral Maxillofac Surg. 76:455–459. 2018. View Article : Google Scholar : PubMed/NCBI

36 

O'Brien KF, Shah SD, Pope E, Phillips RJ, Blei F, Baselga E, Garzon MC, McCuaig C, Haggstrom AN, Hoeger PH, et al: Late growth of infantile hemangiomas in children >3 years of age: A retrospective study. J Am Acad Dermatol. 80:493–499. 2019. View Article : Google Scholar

37 

Guntinas-Lichius O, Klussmann JP, Schroeder U, Quante G, Jungehuelsing M and Stennert E: Primary parotid malignoma surgery in patients with normal preoperative facial nerve function: Outcome and long-term postoperative facial nerve function. Laryngoscope. 114:949–956. 2004. View Article : Google Scholar : PubMed/NCBI

38 

Lim YC, Lee SY, Kim K, Lee JS, Koo BS, Shin HA and Choi EC: Conservative parotidectomy for the treatment of parotid cancers. Oral Oncol. 41:1021–1027. 2005. View Article : Google Scholar

39 

Eisele DW, Wang SJ and Orloff LA: Electrophysiologic facial nerve monitoring during parotidectomy. Head Neck. 32:399–405. 2010.PubMed/NCBI

40 

Bonavolonta P, Dell'Aversana Orabona G, Maglitto F, Abbate V, Committeri U, Salzano G, Improta G, Iaconetta G and Califano L: Postoperative complications after removal of pleomorphic adenoma from the parotid gland: A long-term follow up of 297 patients from 2002 to 2016 and a review of publications. Br J Oral Maxillofac Surg. 57:998–1002. 2019. View Article : Google Scholar : PubMed/NCBI

41 

Ikoma R, Ishitoya J, Sakuma Y, Hirama M, Shiono O, Komatsu M and Oridate N: Temporary facial nerve dysfunction after parotidectomy correlates with tumor location. Auris Nasus Larynx. 41:479–484. 2014. View Article : Google Scholar : PubMed/NCBI

42 

Patel DK, Ahmad Z and Morton RP: Partial superficial parotidectomy with retrograde dissection of the facial nerve for clinically ‘Benign’ parotid tumors. Ann Otol Rhinol Laryngol. 125:808–814. 2016. View Article : Google Scholar

43 

Auger SR, Kramer DE, Hardy B, Jandali D, Stenson K, Kocak M and Al-Khudari S: Functional outcomes after extracapsular dissection with partial facial nerve dissection for small and large parotid neoplasms. Am J Otolaryngol. 42:1027702021. View Article : Google Scholar

44 

Cannon CR, Replogle WH and Schenk MP: Facial nerve in parotidectomy: A topographical analysis. Laryngoscope. 114:2034–2037. 2004. View Article : Google Scholar : PubMed/NCBI

45 

Wong WK and Shetty S: The extent of surgery for benign parotid pathology and its influence on complications: A prospective cohort analysis. Am J Otolaryngol. 39:162–166. 2018. View Article : Google Scholar

46 

Savvas E, Hillmann S, Weiss D, Koopmann M, Rudack C and Alberty J: Association between facial nerve monitoring with postoperative facial paralysis in parotidectomy. JAMA Otolaryngol Head Neck Surg. 142:828–833. 2016. View Article : Google Scholar : PubMed/NCBI

47 

Goode RK, Auclair PL and Ellis GL: Mucoepidermoid carcinoma of the major salivary glands: Clinical and histopathologic analysis of 234 cases with evaluation of grading criteria. Cancer. 82:1217–1224. 1998. View Article : Google Scholar : PubMed/NCBI

48 

Brandwein MS, Ivanov K, Wallace DI, Hille JJ, Wang B, Fahmy A, Bodian C, Urken ML, Gnepp DR, Huvos A, et al: Mucoepidermoid carcinoma: A clinicopathologic study of 80 patients with special reference to histological grading. Am J Surg Pathol. 25:835–845. 2001. View Article : Google Scholar

49 

Tonon G, Modi S, Wu L, Kubo A, Coxon AB, Komiya T, O'Neil K, Stover K, El-Naggar A, Griffin JD, et al: t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway. Nat Genet. 33:208–213. 2003. View Article : Google Scholar

50 

Okabe M, Miyabe S, Nagatsuka H, Terada A, Hanai N, Yokoi M, Shimozato K, Eimoto T, Nakamura S, Nagai N, et al: MECT1-MAML2 fusion transcript defines a favorable subset of mucoepidermoid carcinoma. Clin Cancer Res. 12:3902–3907. 2006. View Article : Google Scholar : PubMed/NCBI

51 

Griffith CC, Schmitt AC, Little JL and Magliocca KR: New developments in salivary gland pathology: Clinically useful ancillary testing and new potentially targetable molecular alterations. Arch Pathol Lab Med. 141:381–395. 2017. View Article : Google Scholar : PubMed/NCBI

52 

Cipriani NA, Lusardi JJ, McElherne J, Pearson AT, Olivas AD, Fitzpatrick C, Lingen MW and Blair EA: Mucoepidermoid carcinoma: A comparison of histologic grading systems and relationship to MAML2 rearrangement and prognosis. Am J Surg Pathol. 43:885–897. 2019. View Article : Google Scholar

53 

Kawata R, Koutetsu L, Yoshimura K, Nishikawa S and Takenaka H: Indication for elective neck dissection for N0 carcinoma of the parotid gland: A single institution's 20-year experience. Acta Otolaryngol. 130:286–292. 2010. View Article : Google Scholar

54 

Shinomiya H, Otsuki N, Yamashita D and Nibu K: Patterns of lymph node metastasis of parotid cancer. Auris Nasus Larynx. 43:446–450. 2016. View Article : Google Scholar : PubMed/NCBI

55 

Lau VH, Aouad R, Farwell DG, Donald PJ and Chen AM: Patterns of nodal involvement for clinically N0 salivary gland carcinoma: Refining the role of elective neck irradiation. Head Neck. 36:1435–1439. 2014. View Article : Google Scholar : PubMed/NCBI

56 

Stodulski D, Mikaszewski B, Majewska H, Wisniewski P and Stankiewicz C: Probability and pattern of occult cervical lymph node metastases in primary parotid carcinoma. Eur Arch Otorhinolaryngol. 274:1659–1664. 2017. View Article : Google Scholar

57 

Armstrong JG, Harrison LB, Thaler HT, Friedlander-Klar H, Fass DE, Zelefsky MJ, Shah JP, Strong EW and Spiro RH: The indications for elective treatment of the neck in cancer of the major salivary glands. Cancer. 69:615–619. 1992. View Article : Google Scholar : PubMed/NCBI

58 

Medina JE: Neck dissection in the treatment of cancer of major salivary glands. Otolaryngol Clin North Am. 31:815–822. 1998. View Article : Google Scholar : PubMed/NCBI

59 

Trojanowski P, Szymanski M, Trojanowska A, Andrzejczak A, Szczepanek D and Klatka J: Anterolateral thigh free flap in reconstruction of lateral skull base defects after oncological resection. Eur Arch Otorhinolaryngol. 276:3487–3494. 2019. View Article : Google Scholar

60 

Aro K, Ho AS, Luu M, Kim S, Tighiouart M, Yoshida EJ, Mallen-St Clair J, Shiao SL, Leivo I and Zumsteg ZS: Survival impact of adjuvant therapy in salivary gland cancers following resection and neck dissection. Otolaryngol Head Neck Surg. 160:1048–1057. 2019. View Article : Google Scholar : PubMed/NCBI

61 

Renehan AG, Gleave EN, Slevin NJ and McGurk M: Clinico-pathological and treatment-related factors influencing survival in parotid cancer. Br J Cancer. 80:1296–1300. 1999. View Article : Google Scholar : PubMed/NCBI

62 

Kim YH, Chung WK, Jeong JU, Cho IJ, Yoon MS, Song JY, Nam TK, Ahn SJ, Lee DH, Yoon TM, et al: Evaluation of prognostic factors for the parotid cancer treated with surgery and postoperative radiotherapy. Clin Exp Otorhinolaryngol. 13:69–76. 2020. View Article : Google Scholar

63 

Erovic BM, Shah MD, Bruch G, Johnston M, Kim J, O'Sullivan B, Perez-Ordonez B, Weinreb I, Atenafu EG, de Almeida JR, et al: Outcome analysis of 215 patients with parotid gland tumors: A retrospective cohort analysis. J Otolaryngol Head Neck Surg. 44:432015. View Article : Google Scholar : PubMed/NCBI

64 

Vander Poorten VL, Hart AA, van der Laan BF, Baatenburg de Jong RJ, Manni JJ, Marres HA, Meeuwis CA, Lubsen H, Terhaard CH and Balm AJ: Prognostic index for patients with parotid carcinoma: External validation using the nationwide 1985–1994 dutch head and neck oncology cooperative group database. Cancer. 97:1453–1463. 2003. View Article : Google Scholar : PubMed/NCBI

65 

Mercante G, Marchese C, Giannarelli D, Pellini R, Cristalli G, Manciocco V, Ruscito P, Pichi B, Marchesi P and Spriano G: Oncological outcome and prognostic factors in malignant parotid tumours. J Craniomaxillofac Surg. 42:59–65. 2014. View Article : Google Scholar : PubMed/NCBI

66 

Lima RA, Tavares MR, Dias FL, Kligerman J, Nascimento MF, Barbosa MM, Cernea CR, Soares JR, Santos IC and Salviano S: Clinical prognostic factors in malignant parotid gland tumors. Otolaryngol Head Neck Surg. 133:702–708. 2005. View Article : Google Scholar : PubMed/NCBI

67 

Shang J, Wu Y, Wang W, Wang K and Ge M: Analysis of prognostic risk factors and treatment of parotid cancer. Oncol Lett. 3:1307–1310. 2012. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Suzuki S, Bandoh N, Goto T, Kubota A, Uemura A, Kono M, Sato R, Takeda R, Sakaue S, Yamaguchi‑Isochi T, Yamaguchi‑Isochi T, et al: A retrospective study of parotid gland tumors at a single institution. Oncol Lett 24: 207, 2022.
APA
Suzuki, S., Bandoh, N., Goto, T., Kubota, A., Uemura, A., Kono, M. ... Harabuchi, Y. (2022). A retrospective study of parotid gland tumors at a single institution. Oncology Letters, 24, 207. https://doi.org/10.3892/ol.2022.13328
MLA
Suzuki, S., Bandoh, N., Goto, T., Kubota, A., Uemura, A., Kono, M., Sato, R., Takeda, R., Sakaue, S., Yamaguchi‑Isochi, T., Nishihara, H., Takei, H., Harabuchi, Y."A retrospective study of parotid gland tumors at a single institution". Oncology Letters 24.1 (2022): 207.
Chicago
Suzuki, S., Bandoh, N., Goto, T., Kubota, A., Uemura, A., Kono, M., Sato, R., Takeda, R., Sakaue, S., Yamaguchi‑Isochi, T., Nishihara, H., Takei, H., Harabuchi, Y."A retrospective study of parotid gland tumors at a single institution". Oncology Letters 24, no. 1 (2022): 207. https://doi.org/10.3892/ol.2022.13328
Copy and paste a formatted citation
x
Spandidos Publications style
Suzuki S, Bandoh N, Goto T, Kubota A, Uemura A, Kono M, Sato R, Takeda R, Sakaue S, Yamaguchi‑Isochi T, Yamaguchi‑Isochi T, et al: A retrospective study of parotid gland tumors at a single institution. Oncol Lett 24: 207, 2022.
APA
Suzuki, S., Bandoh, N., Goto, T., Kubota, A., Uemura, A., Kono, M. ... Harabuchi, Y. (2022). A retrospective study of parotid gland tumors at a single institution. Oncology Letters, 24, 207. https://doi.org/10.3892/ol.2022.13328
MLA
Suzuki, S., Bandoh, N., Goto, T., Kubota, A., Uemura, A., Kono, M., Sato, R., Takeda, R., Sakaue, S., Yamaguchi‑Isochi, T., Nishihara, H., Takei, H., Harabuchi, Y."A retrospective study of parotid gland tumors at a single institution". Oncology Letters 24.1 (2022): 207.
Chicago
Suzuki, S., Bandoh, N., Goto, T., Kubota, A., Uemura, A., Kono, M., Sato, R., Takeda, R., Sakaue, S., Yamaguchi‑Isochi, T., Nishihara, H., Takei, H., Harabuchi, Y."A retrospective study of parotid gland tumors at a single institution". Oncology Letters 24, no. 1 (2022): 207. https://doi.org/10.3892/ol.2022.13328
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team