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A pathological complete response after nivolumab plus ipilimumab therapy for DNA mismatch repair‑deficient/microsatellite instability‑high metastatic colon cancer: A case report

  • Authors:
    • Shota Igaue
    • Takayuki Okuno
    • Hajime Ishibashi
    • Masaru Nemoto
    • Masaya Hiyoshi
    • Hiroshi Kawasaki
    • Hitoaki Saitoh
    • Makoto Saitoh
    • Kiwamu Akagi
    • Junji Yamamoto
  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal Surgery, Ibaraki Cancer Center, Ibaraki Prefectural Central Hospital, Kasama, Ibaraki 309‑1793, Japan, Department of Gastroenterology, Ibaraki Cancer Center, Ibaraki Prefectural Central Hospital, Kasama, Ibaraki 309‑1793, Japan, Department of Pathology, Ibaraki Cancer Center, Ibaraki Prefectural Central Hospital, Kasama, Ibaraki 309‑1793, Japan, Center for Clinical Genetics and Genomics, Ibaraki Cancer Center, Ibaraki Prefectural Central Hospital, Kasama, Ibaraki 309‑1793, Japan, Division of Molecular Diagnosis and Cancer Prevention, Saitama Cancer Center, Kitaadachi‑gun, Saitama 362‑0806, Japan
    Copyright: © Igaue et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].
  • Article Number: 211
    |
    Published online on: May 17, 2022
       https://doi.org/10.3892/ol.2022.13332
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Abstract

The standard treatment for colorectal cancer has always been surgery and chemotherapy, which may be used in combination to treat patients. Immune checkpoint inhibitors have been a significant advancement in the standard treatment of metastatic, unresectable colorectal cancer with deficient mismatch repair. However, little information is available about their use in neoadjuvant and conversion settings with only a few case reports and only one phase 2 trial. The present study reports the case of a large, locally advanced right‑sided metastatic deficient mismatch repair/microsatellite instability‑high colon cancer, which showed a pathological complete response after combination treatment with nivolumab and ipilimumab. To the best of our knowledge, resected metastatic colon cancer with a pathological complete response after treatment using dual immune checkpoint inhibitors has not been previously reported. Overall, this case report suggests the use of immune checkpoint inhibitors before colorectal surgery.
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Copy and paste a formatted citation
Spandidos Publications style
Igaue S, Okuno T, Ishibashi H, Nemoto M, Hiyoshi M, Kawasaki H, Saitoh H, Saitoh M, Akagi K, Yamamoto J, Yamamoto J, et al: A pathological complete response after nivolumab plus ipilimumab therapy for DNA mismatch repair‑deficient/microsatellite instability‑high metastatic colon cancer: A case report. Oncol Lett 24: 211, 2022.
APA
Igaue, S., Okuno, T., Ishibashi, H., Nemoto, M., Hiyoshi, M., Kawasaki, H. ... Yamamoto, J. (2022). A pathological complete response after nivolumab plus ipilimumab therapy for DNA mismatch repair‑deficient/microsatellite instability‑high metastatic colon cancer: A case report. Oncology Letters, 24, 211. https://doi.org/10.3892/ol.2022.13332
MLA
Igaue, S., Okuno, T., Ishibashi, H., Nemoto, M., Hiyoshi, M., Kawasaki, H., Saitoh, H., Saitoh, M., Akagi, K., Yamamoto, J."A pathological complete response after nivolumab plus ipilimumab therapy for DNA mismatch repair‑deficient/microsatellite instability‑high metastatic colon cancer: A case report". Oncology Letters 24.1 (2022): 211.
Chicago
Igaue, S., Okuno, T., Ishibashi, H., Nemoto, M., Hiyoshi, M., Kawasaki, H., Saitoh, H., Saitoh, M., Akagi, K., Yamamoto, J."A pathological complete response after nivolumab plus ipilimumab therapy for DNA mismatch repair‑deficient/microsatellite instability‑high metastatic colon cancer: A case report". Oncology Letters 24, no. 1 (2022): 211. https://doi.org/10.3892/ol.2022.13332
Copy and paste a formatted citation
x
Spandidos Publications style
Igaue S, Okuno T, Ishibashi H, Nemoto M, Hiyoshi M, Kawasaki H, Saitoh H, Saitoh M, Akagi K, Yamamoto J, Yamamoto J, et al: A pathological complete response after nivolumab plus ipilimumab therapy for DNA mismatch repair‑deficient/microsatellite instability‑high metastatic colon cancer: A case report. Oncol Lett 24: 211, 2022.
APA
Igaue, S., Okuno, T., Ishibashi, H., Nemoto, M., Hiyoshi, M., Kawasaki, H. ... Yamamoto, J. (2022). A pathological complete response after nivolumab plus ipilimumab therapy for DNA mismatch repair‑deficient/microsatellite instability‑high metastatic colon cancer: A case report. Oncology Letters, 24, 211. https://doi.org/10.3892/ol.2022.13332
MLA
Igaue, S., Okuno, T., Ishibashi, H., Nemoto, M., Hiyoshi, M., Kawasaki, H., Saitoh, H., Saitoh, M., Akagi, K., Yamamoto, J."A pathological complete response after nivolumab plus ipilimumab therapy for DNA mismatch repair‑deficient/microsatellite instability‑high metastatic colon cancer: A case report". Oncology Letters 24.1 (2022): 211.
Chicago
Igaue, S., Okuno, T., Ishibashi, H., Nemoto, M., Hiyoshi, M., Kawasaki, H., Saitoh, H., Saitoh, M., Akagi, K., Yamamoto, J."A pathological complete response after nivolumab plus ipilimumab therapy for DNA mismatch repair‑deficient/microsatellite instability‑high metastatic colon cancer: A case report". Oncology Letters 24, no. 1 (2022): 211. https://doi.org/10.3892/ol.2022.13332
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