Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
July-2022 Volume 24 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2022 Volume 24 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

A study on DNA methylation modifying natural compounds identified EGCG for induction of IFI16 gene expression related to the innate immune response in cancer cells

  • Authors:
    • Mohammad Imran Khan
    • Suza Mohammad Nur
    • Wesam H. Abdulaal
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia
    Copyright: © Khan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 218
    |
    Published online on: May 19, 2022
       https://doi.org/10.3892/ol.2022.13339
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Innate immune sensor IFN‑induced protein 16 (IFI16) exhibits anti‑inflammatory effects via IFNβ and IFN‑stimulated gene (ISG)15 induction in cancer cells. Epigallocatechin gallate (EGCG) is a potent natural DNA methyltransferase inhibitor (DNMTi). Previous studies revealed that conventional DNMTis, such as 5‑azacytidine (5‑aza‑dc), induce IFI16 expression and EGCG decreases DNMT mRNA expression and global methylation (5mC) level via promoter demethylation of tumor suppressor genes in cancer cell lines. To the best of our knowledge, however, EGCG‑mediated IFI16 promoter methylation status has been overlooked. Here, initial screening was performed to determine IFI16 expression and its correlation with DNMTs in cancer cell lines from various databases. Following treatment of breast cancer cell lines with 5‑aza‑dc, vitamin C and EGCG, expression levels of IFI16 and its downstream transcription targets IFNβ1 and ISG15 were assessed using RT-qPCR, and the 5mC level was assessed using ELISA. In silico molecular docking simulation was performed for all DNMTs to predict the mode of ligands binding with proteins. Finally, promoter methylation level in IFI16 gene was assessed following EGCG treatment. EGCG treatment induced IFI16 expression, interacted with certain amino acids residues in DNMT proteins and decreased 5mC level and promoter methylation of IFI16. The present results may provide a basis for targeting IFI16 expression as a therapeutic option in breast cancer cell lines.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

View References

1 

Choubey D and Panchanathan R: IFI16, an amplifier of DNA-damage response: Role in cellular senescence and aging-associated inflammatory diseases. Ageing Res Rev. 28:27–36. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Ouchi M and Ouchi T: Role of IFI16 in DNA damage and checkpoint. Front Biosci. 13:236–239. 2008. View Article : Google Scholar

3 

Duan X, Ponomareva L, Veeranki S, Panchanathan R, Dickerson E and Choubey D: Differential roles for the interferon-inducible IFI16 and AIM2 innate immune sensors for cytosolic DNA in cellular senescence of human fibroblasts. Mol Cancer Res. 9:589–602. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Stratmann SA, Morrone SR, van Oijen AM and Sohn J: The innate immune sensor IFI16 recognizes foreign DNA in the nucleus by scanning along the duplex. ELife. 4:e117212015. View Article : Google Scholar : PubMed/NCBI

5 

Unterholzner L, Keating SE, Baran M, Horan KA, Jensen SB, Sharma S, Sirois CM, Jin T, Latz E, Xiao TS, et al: IFI16 is an innate immune sensor for intracellular DNA. Nat Immunol. 11:997–1004. 2010. View Article : Google Scholar

6 

Orzalli MH, DeLuca NA and Knipe DM: Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein. Proc Natl Acad Sci USA. 109:E3008–E3017. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Choubey D, Deka R and Ho SM: Interferon-inducible IFI16 protein in human cancers and autoimmune diseases. Front Biosci. 13:598–608. 2008. View Article : Google Scholar

8 

Johnstone RW and Trapani JA: Transcription and growth regulatory functions of the HIN-200 family of proteins. Mol Cell Biol. 19:5833–5838. 1999. View Article : Google Scholar

9 

Ludlow LE, Johnstone RW and Clarke CJ: The HIN-200 family: More than interferon-inducible genes? Exp Cell Res. 308:1–17. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Choubey D, Duan X, Dickerson E, Ponomareva L, Panchanathan R, Shen H and Srivastava R: Interferon-inducible p200-family proteins as novel sensors of cytoplasmic DNA: Role in inflammation and autoimmunity. J Interferon Cytokine Res. 30:371–380. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Veeranki S and Choubey D: Interferon-inducible p200-family protein IFI16, an innate immune sensor for cytosolic and nuclear double-stranded DNA: Regulation of subcellular localization. Mol Immunol. 49:567–571. 2012. View Article : Google Scholar

12 

Decout A, Katz JD, Venkatraman S and Ablasser A: The cGAS-STING pathway as a therapeutic target in inflammatory diseases. Nat Rev Immunol. 21:548–569. 2021. View Article : Google Scholar

13 

Bhat N and Fitzgerald KA: Recognition of cytosolic DNA by cGAS and other STING-dependent sensors. Eur J Immunol. 44:634–640. 2014. View Article : Google Scholar

14 

Thompson MR, Sharma S, Atianand M, Jensen SB, Carpenter S, Knipe DM, Fitzgerald KA and Kurt-Jones EA: Interferon γ-inducible Protein (IFI) 16 transcriptionally regulates Type I interferons and other interferon-stimulated genes and controls the interferon response to both DNA and RNA viruses. J Biol Chem. 289:235682014. View Article : Google Scholar : PubMed/NCBI

15 

Kopitar-Jerala N: The role of interferons in inflammation and inflammasome activation. Front Immunol. 8:8732017. View Article : Google Scholar

16 

Itsui Y, Sakamoto N, Kurosaki M, Kanazawa N, Tanabe Y, Koyama T, Takeda Y, Nakagawa M, Kakinuma S and Sekine Y: Expressional screening of interferon-stimulated genes for antiviral activity against hepatitis C virus replication. J Viral Hepat. 13:690–700. 2006. View Article : Google Scholar

17 

Jiang D, Guo H, Xu C, Chang J, Gu B, Wang L, Block TM and Guo JT: Identification of three interferon-inducible cellular enzymes that inhibit the replication of hepatitis C virus. J Virol. 82:1665–1678. 2008. View Article : Google Scholar

18 

Schoggins JW and Rice CM: Interferon-stimulated genes and their antiviral effector functions. Curr Opin Virol. 1:5192011. View Article : Google Scholar

19 

Xin H, Curry J, Johnstone RW, Nickoloff BJ and Choubey D: Role of IFI 16, a member of the interferon-inducible p200-protein family, in prostate epithelial cellular senescence. Oncogene. 22:4831–4840. 2003. View Article : Google Scholar : PubMed/NCBI

20 

Duan X, Ponomareva L, Veeranki S and Choubey D: IFI16 induction by glucose restriction in human fibroblasts contributes to autophagy through activation of the ATM/AMPK/p53 pathway. PLoS One. 6:e1953220122 View Article : Google Scholar : PubMed/NCBI

21 

Lin W, Zhao Z, Ni Z, Zhao Y, Du W and Chen S: IFI16 restoration in hepatocellular carcinoma induces tumour inhibition via activation of p53 signals and inflammasome. Cell Prolif. 50:e123922017. View Article : Google Scholar

22 

Kondo Y, Nagai K, Nakahata S, Saito Y, Ichikawa T, Suekane A, Taki T, Iwakawa R, Enari M, Taniwaki M, et al: Overexpression of the DNA sensor proteins, absent in melanoma 2 and interferon-inducible 16, contributes to tumorigenesis of oral squamous cell carcinoma with p53 inactivation. Cancer Sci. 103:782–790. 2012. View Article : Google Scholar

23 

Yu B, Zheng X, Sun Z, Cao P, Zhang J and Wang W: IFI16 can be used as a biomarker for diagnosis of renal cell carcinoma and prediction of patient survival. Front Genet. 12:5999522012. View Article : Google Scholar

24 

Chen JX, Cheng CS, Gao HF, Chen ZJ, Lv LL, Xu JY, Shen XH, Xie J and Zheng L: Overexpression of interferon-inducible Protein 16 promotes progression of human pancreatic adenocarcinoma through interleukin-1β-induced tumor-associated macrophage infiltration in the tumor microenvironment. Front Cell Dev Biol. 9:6407862021. View Article : Google Scholar

25 

Intra J and Kuo SM: Physiological levels of tea catechins increase cellular lipid antioxidant activity of vitamin C and vitamin E in human intestinal Caco-2 cells. Chem Biol Interact. 169:91–99. 2007. View Article : Google Scholar

26 

Cione E, La Torre C, Cannataro R, Caroleo MC, Plastina P and Gallelli L: Quercetin, epigallocatechin gallate, curcumin, and resveratrol: From dietary sources to human MicroRNA modulation. Molecules. 25:632019. View Article : Google Scholar

27 

Fang MZ, Wang Y, Ai N, Hou Z, Sun Y, Lu H, Welsh W and Yang CS: Tea polyphenol (−)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines. Cancer Res. 63:7563–7570. 2003.PubMed/NCBI

28 

Beetch M, Harandi-Zadeh S, Shen K, Lubecka K, Kitts DD, O'Hagan HM and Stefanska B: Dietary antioxidants remodel DNA methylation patterns in chronic disease. Br J Pharmacol. 177:1382–1408. 2020. View Article : Google Scholar

29 

Kuo CL, Chen TS, Liou SY and Hsieh CC: Immunomodulatory effects of EGCG fraction of green tea extract in innate and adaptive immunity via T regulatory cells in murine model. Immunopharmacol Immunotoxicol. 36:364–370. 2014. View Article : Google Scholar

30 

Nance Cl, Mata M, McMullen A, McMullen A and Shearer WT: Regulation of innate immune recognition of viral infection by epigallocatechin gallate. J Allergy Clin Immunol. 133:AB2462014. View Article : Google Scholar

31 

Liu M, Ohtani H, Zhou W, Ørskov AD, Charlet J, Zhang YW, Shen H, Baylin SB, Liang G, Grønbæk K and Jones PA: Vitamin C increases viral mimicry induced by 5-aza-2′-deoxycytidine. Proc Natl Acad Sci USA. 113:10238–10244. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Li T, Diner BA, Chen J and Cristea IM: Acetylation modulates cellular distribution and DNA sensing ability of interferon-inducible protein IFI16. Proc Natl Acad Sci. 109:10558–10563. 2012. View Article : Google Scholar

33 

Alimirah F, Chen J, Davis FJ and Choubey D: IFI16 in human prostate cancer. Mol Cancer Res. 5:251–259. 2007. View Article : Google Scholar : PubMed/NCBI

34 

Takeshima H, Yoda Y, Wakabayashi M, Hattori N, Yamashita S and Ushijima T: Low-dose DNA demethylating therapy induces reprogramming of diverse cancer-related pathways at the single-cell level. Clin Epigenetics. 12:1422020. View Article : Google Scholar : PubMed/NCBI

35 

Morris J, Moseley VR, Cabang AB, Coleman K, Wei W, Garrett-Mayer E and Wargovich MJ: Reduction in promotor methylation utilizing EGCG (epigallocatechin-3-gallate) restores RXRα expression in human colon cancer cells. Oncotarget. 7:35313–35326. 2016. View Article : Google Scholar

36 

Huang CY, Han Z, Li X, Xie HH and Zhu SS: Mechanism of EGCG promoting apoptosis of MCF-7 cell line in human breast cancer. Oncol Lett. 14:3623–3627. 2017. View Article : Google Scholar

37 

Moradzadeh M, Hosseini A, Erfanian S and Rezaei H: Epigallocatechin-3-gallate promotes apoptosis in human breast cancer T47D cells through down-regulation of PI3K/AKT and Telomerase. Pharmacol Rep. 69:924–928. 2017. View Article : Google Scholar : PubMed/NCBI

38 

Roulois D, Loo Yau H, Singhania R, Wang Y, Danesh A, Shen SY, Han H, Liang G, Jones PA, Pugh TJ, et al: DNA-demethylating agents target colorectal cancer cells by inducing viral mimicry by endogenous transcripts. Cell. 162:961–973. 2015. View Article : Google Scholar

39 

Rialdi A, Campisi L, Zhao N, Lagda AC, Pietzsch C, Ho JSY, Martinez-Gil L, Fenouil R, Chen X, Edwards M, et al: Topoisomerase 1 inhibition suppresses inflammatory genes and protects from death by inflammation. Science. 352:aad79932016. View Article : Google Scholar : PubMed/NCBI

40 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

41 

Islam MR, Awal MA, Khames A, Abourehab MAS, Samad A, Hassan WMI, Alam R, Osman OI, Nur SM, Molla MHR, et al: Computational identification of druggable bioactive compounds from catharanthus roseus and avicennia marina against colorectal cancer by targeting thymidylate synthase. Mol. 27:20892022. View Article : Google Scholar

42 

Ikwu FA, Shallangwa GA, Mamza PA and Uzairu A: In silico studies of piperazine derivatives as potent anti-proliferative agents against PC-3 prostate cancer cell lines. Heliyon. 6:e032732020. View Article : Google Scholar : PubMed/NCBI

43 

Zevini A, Olagnier D and Hiscott J: Crosstalk between cytoplasmic RIG-I and STING sensing pathways. Trends Immunol. 38:194–205. 2017. View Article : Google Scholar

44 

Nur SM, Rath S, Ahmad V, Ahmad A, Ateeq B and Khan MI: Nutritive vitamins as epidrugs. Crit Rev Food Sci Nutr. 61:1–13. 2021. View Article : Google Scholar : PubMed/NCBI

45 

de Ruyck J, Brysbaert G, Blossey R and Lensink MF: Molecular docking as a popular tool in drug design, an in silico travel. Adv Appl Bioinform Chem. 9:1–11. 2016.PubMed/NCBI

46 

Won JL, Shim JY and Zhu BT: Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids. Mol Pharmacol. 68:1018–1030. 2005. View Article : Google Scholar

47 

Okude H, Ori D and Kawai T: Signaling through nucleic acid sensors and their roles in inflammatory diseases. Front Immunol. 11:6258332021. View Article : Google Scholar

48 

Chiappinelli KB, Strissel PL, Desrichard A, Li H, Henke C, Akman B, Hein A, Rote NS, Cope LM, Snyder A, et al: Erratum: Inhibiting DNA methylation causes an interferon response in cancer via dsRNA including endogenous retroviruses. Cell. 152:974–986. 2015. View Article : Google Scholar

49 

Sheng J, Shi W, Guo H, Long W, Wang Y, Qi J, Liu J and Xu Y: The inhibitory effect of (−)-Epigallocatechin-3-Gallate on breast cancer progression via reducing SCUBE2 methylation and DNMT activity. Molecules. 24:28992019. View Article : Google Scholar

50 

Nandakumar V, Vaid M and Katiyar SK: (−)-Epigallocatechin-3-gallate reactivates silenced tumor suppressor genes, Cip1/p21 and p 16 INK4a, by reducing DNA methylation and increasing histones acetylation in human skin cancer cells. Carcinogenesis. 32:537–544. 2011. View Article : Google Scholar : PubMed/NCBI

51 

Blaschke K, Ebata KT, Karimi MM, Zepeda-Martínez JA, Goyal P, Mahapatra S, Tam A, Laird DJ, Hirst M, Rao A, et al: Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells. Nature. 500:222–226. 2013. View Article : Google Scholar : PubMed/NCBI

52 

Rajavelu A, Lungu C, Emperle M, Dukatz M, Bröhm A, Broche J, Hanelt I, Parsa E, Schiffers S, Karnik R, et al: Chromatin-dependent allosteric regulation of DNMT3A activity by MeCP2. Nucleic Acids Res. 46:9044–9056. 2018. View Article : Google Scholar : PubMed/NCBI

53 

Bostick M, Jong KK, Estève PO, Clark A, Pradhan S and Jacobsen SE: UHRF1 plays a role in maintaining DNA methylation in mammalian cells. Science. 317:1760–1764. 2007. View Article : Google Scholar : PubMed/NCBI

54 

Khan MA, Hussain A, Sundaram MK, Alalami U, Gunasekera D, Ramesh L, Hamza A and Quraishi U: (−)-Epigallocatechin-3-gallate reverses the expression of various tumor-suppressor genes by inhibiting DNA methyltransferases and histone deacetylases in human cervical cancer cells. Oncol Rep. 33:1976–1984. 2015. View Article : Google Scholar : PubMed/NCBI

55 

Yiannakopoulou EC: Targeting DNA methylation with green tea catechins. Pharmacology. 95:111–116. 2015. View Article : Google Scholar : PubMed/NCBI

56 

Alivand MR, Najafi S, Esmaeili S, Rahmanpour D, Zhaleh H and Rahmati Y: Integrative analysis of DNA methylation and gene expression profiles to identify biomarkers of glioblastoma. Cancer Genet. 258–259. 135–150. 2021.

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Khan MI, Nur SM and Abdulaal WH: A study on DNA methylation modifying natural compounds identified EGCG for induction of IFI16 gene expression related to the innate immune response in cancer cells. Oncol Lett 24: 218, 2022.
APA
Khan, M.I., Nur, S.M., & Abdulaal, W.H. (2022). A study on DNA methylation modifying natural compounds identified EGCG for induction of IFI16 gene expression related to the innate immune response in cancer cells. Oncology Letters, 24, 218. https://doi.org/10.3892/ol.2022.13339
MLA
Khan, M. I., Nur, S. M., Abdulaal, W. H."A study on DNA methylation modifying natural compounds identified EGCG for induction of IFI16 gene expression related to the innate immune response in cancer cells". Oncology Letters 24.1 (2022): 218.
Chicago
Khan, M. I., Nur, S. M., Abdulaal, W. H."A study on DNA methylation modifying natural compounds identified EGCG for induction of IFI16 gene expression related to the innate immune response in cancer cells". Oncology Letters 24, no. 1 (2022): 218. https://doi.org/10.3892/ol.2022.13339
Copy and paste a formatted citation
x
Spandidos Publications style
Khan MI, Nur SM and Abdulaal WH: A study on DNA methylation modifying natural compounds identified EGCG for induction of IFI16 gene expression related to the innate immune response in cancer cells. Oncol Lett 24: 218, 2022.
APA
Khan, M.I., Nur, S.M., & Abdulaal, W.H. (2022). A study on DNA methylation modifying natural compounds identified EGCG for induction of IFI16 gene expression related to the innate immune response in cancer cells. Oncology Letters, 24, 218. https://doi.org/10.3892/ol.2022.13339
MLA
Khan, M. I., Nur, S. M., Abdulaal, W. H."A study on DNA methylation modifying natural compounds identified EGCG for induction of IFI16 gene expression related to the innate immune response in cancer cells". Oncology Letters 24.1 (2022): 218.
Chicago
Khan, M. I., Nur, S. M., Abdulaal, W. H."A study on DNA methylation modifying natural compounds identified EGCG for induction of IFI16 gene expression related to the innate immune response in cancer cells". Oncology Letters 24, no. 1 (2022): 218. https://doi.org/10.3892/ol.2022.13339
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team