Interferon‑α and its effects on cancer cell apoptosis (Review)
- Weiye Shi
- Xu Yao
- Yu Fu
- Yingze Wang
Affiliations: College of Food Science and Biology, Hebei University of Science and Technology, Shijiazhuang, Hebei 050018, P.R. China, College of Food Science and Biology, Hebei University of Science and Technology, Shijiazhuang, Hebei 050018, P.R. China
- Published online on: May 30, 2022 https://doi.org/10.3892/ol.2022.13355
Copyright: © Shi
et al. This is an open access article distributed under the
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Commons Attribution License.
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Interferon (IFN)‑α is a cytokine that exhibits a wide range of biological activities and is used in various cancer treatments. It regulates numerous genes that serve roles in antiviral, antiproliferative and proapoptotic activities. For decades, one of the main aspects of clinical oncology has been the development of anticancer therapeutics that promote the effective elimination of cancer cells via apoptosis. However, the updated available information concerning IFN‑α‑induced cancer cell apoptosis needs to be assembled, so as to provide an improved theoretical reference for the basic scientific research and clinical treatment of malignant tumors. Therefore, the present review focuses on the potential effects of IFN‑α in inducing cancer cell apoptosis. The biological characteristics of IFN‑α, the apoptotic signaling pathways and molecular mechanisms of apoptosis caused by IFN‑α are discussed in different types of cancer cells. The present review provided a comprehensive understanding of the effects of IFN‑α on cancer cell apoptosis, which will aid in developing more efficient strategies to effectively control the progression of certain cancers.