Open Access

Interferon‑α and its effects on cancer cell apoptosis (Review)

  • Authors:
    • Weiye Shi
    • Xu Yao
    • Yu Fu
    • Yingze Wang
  • View Affiliations

  • Published online on: May 30, 2022     https://doi.org/10.3892/ol.2022.13355
  • Article Number: 235
  • Copyright: © Shi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Interferon (IFN)‑α is a cytokine that exhibits a wide range of biological activities and is used in various cancer treatments. It regulates numerous genes that serve roles in antiviral, antiproliferative and proapoptotic activities. For decades, one of the main aspects of clinical oncology has been the development of anticancer therapeutics that promote the effective elimination of cancer cells via apoptosis. However, the updated available information concerning IFN‑α‑induced cancer cell apoptosis needs to be assembled, so as to provide an improved theoretical reference for the basic scientific research and clinical treatment of malignant tumors. Therefore, the present review focuses on the potential effects of IFN‑α in inducing cancer cell apoptosis. The biological characteristics of IFN‑α, the apoptotic signaling pathways and molecular mechanisms of apoptosis caused by IFN‑α are discussed in different types of cancer cells. The present review provided a comprehensive understanding of the effects of IFN‑α on cancer cell apoptosis, which will aid in developing more efficient strategies to effectively control the progression of certain cancers.

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July-2022
Volume 24 Issue 1

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Copy and paste a formatted citation
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Spandidos Publications style
Shi W, Yao X, Fu Y and Wang Y: Interferon‑α and its effects on cancer cell apoptosis (Review). Oncol Lett 24: 235, 2022
APA
Shi, W., Yao, X., Fu, Y., & Wang, Y. (2022). Interferon‑α and its effects on cancer cell apoptosis (Review). Oncology Letters, 24, 235. https://doi.org/10.3892/ol.2022.13355
MLA
Shi, W., Yao, X., Fu, Y., Wang, Y."Interferon‑α and its effects on cancer cell apoptosis (Review)". Oncology Letters 24.1 (2022): 235.
Chicago
Shi, W., Yao, X., Fu, Y., Wang, Y."Interferon‑α and its effects on cancer cell apoptosis (Review)". Oncology Letters 24, no. 1 (2022): 235. https://doi.org/10.3892/ol.2022.13355