Open Access

Analysis of the expression, function and signaling of glycogen phosphorylase isoforms in hepatocellular carcinoma

  • Authors:
    • Lingyu Jiang
    • Shuyan Liu
    • Tingzhi Deng
    • Yang Yang
    • Yin Zhang
  • View Affiliations

  • Published online on: June 7, 2022     https://doi.org/10.3892/ol.2022.13364
  • Article Number: 244
  • Copyright: © Jiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Glycogen phosphorylase (GP) is an essential enzyme for glycolysis via the glycogen degradation pathway. It consists of three isoforms: PYGB (brain form), PYGL (liver form) and PYGM (muscle form). Although the abnormal expression of GP is associated with a variety of tumors, its relationship with hepatocellular carcinoma (HCC) and whether it can be used as a prognostic marker of HCC remains unclear. In the present study, the expression levels of PYGB, PYGL and PYGM were analyzed. It was found that the expression levels of PYGB in tumor tissues were higher than those in normal tissues, particularly in HCC. The high expression of PYGB (hazard ratios=1.801; 95% confidence interval: 1.266‑2.562) could predict the poor prognosis of HCC patients but not PYGL and PYGM. Inhibition of PYGB with GP inhibitor CP91149 significantly suppressed the HCC cell proliferation in the HCC cell model. In addition, combination treatment with sorafenib, a standard treatment for HCC, showed a great inhibition on tumor growth and angiogenesis. These findings suggested that PYGB may be used as a therapeutic and prognostic indicator for HCC.
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August-2022
Volume 24 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Jiang L, Liu S, Deng T, Yang Y and Zhang Y: Analysis of the expression, function and signaling of glycogen phosphorylase isoforms in hepatocellular carcinoma. Oncol Lett 24: 244, 2022
APA
Jiang, L., Liu, S., Deng, T., Yang, Y., & Zhang, Y. (2022). Analysis of the expression, function and signaling of glycogen phosphorylase isoforms in hepatocellular carcinoma. Oncology Letters, 24, 244. https://doi.org/10.3892/ol.2022.13364
MLA
Jiang, L., Liu, S., Deng, T., Yang, Y., Zhang, Y."Analysis of the expression, function and signaling of glycogen phosphorylase isoforms in hepatocellular carcinoma". Oncology Letters 24.2 (2022): 244.
Chicago
Jiang, L., Liu, S., Deng, T., Yang, Y., Zhang, Y."Analysis of the expression, function and signaling of glycogen phosphorylase isoforms in hepatocellular carcinoma". Oncology Letters 24, no. 2 (2022): 244. https://doi.org/10.3892/ol.2022.13364