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Case Report Open Access

B‑cell lymphoma‑associated hemophagocytic lymphohistiocytosis: A case report

  • Authors:
    • Ademola S. Ojo
    • Joseph Asemota
    • Somtochukwu Ojukwu
    • Ahmad Rajeh
    • Amina Bot
    • Caitlyn J. Smith
    • Katsiaryna Laziuk
    • Mohammed Saleh
  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine, Howard University Hospital, Washington, DC 20060, USA, Department of Medicine, School of Medicine, University of Missouri, Columbia, MO 65212, USA, Department of Pathology and Anatomical Sciences, School of Medicine, University of Missouri, Columbia, MO 65212, USA
    Copyright: © Ojo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 246
    |
    Published online on: June 7, 2022
       https://doi.org/10.3892/ol.2022.13365
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Abstract

Hemophagocytic lymphohistiocytosis (HLH) is a life‑threatening condition characterized by an exaggerated but dysregulated immune response resulting in hyperinflammation, with a potential for progression to multiple organ dysfunction and failure. Infectious diseases, inflammatory disorders, malignancies and immunodeficiency syndromes are known triggers of HLH in adults. The present study reported the case of a middle‑aged man with HLH triggered by B‑cell lymphoma who was successfully treated with dexamethasone; etoposide, prednisone, vincristine, cyclophosphamide, hydroxy‑doxorubicin and rituximab chemotherapy; and multiple intrathecal methotrexate with a good outcome.
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Copy and paste a formatted citation
Spandidos Publications style
Ojo AS, Asemota J, Ojukwu S, Rajeh A, Bot A, Smith CJ, Laziuk K and Saleh M: B‑cell lymphoma‑associated hemophagocytic lymphohistiocytosis: A case report. Oncol Lett 24: 246, 2022.
APA
Ojo, A.S., Asemota, J., Ojukwu, S., Rajeh, A., Bot, A., Smith, C.J. ... Saleh, M. (2022). B‑cell lymphoma‑associated hemophagocytic lymphohistiocytosis: A case report. Oncology Letters, 24, 246. https://doi.org/10.3892/ol.2022.13365
MLA
Ojo, A. S., Asemota, J., Ojukwu, S., Rajeh, A., Bot, A., Smith, C. J., Laziuk, K., Saleh, M."B‑cell lymphoma‑associated hemophagocytic lymphohistiocytosis: A case report". Oncology Letters 24.2 (2022): 246.
Chicago
Ojo, A. S., Asemota, J., Ojukwu, S., Rajeh, A., Bot, A., Smith, C. J., Laziuk, K., Saleh, M."B‑cell lymphoma‑associated hemophagocytic lymphohistiocytosis: A case report". Oncology Letters 24, no. 2 (2022): 246. https://doi.org/10.3892/ol.2022.13365
Copy and paste a formatted citation
x
Spandidos Publications style
Ojo AS, Asemota J, Ojukwu S, Rajeh A, Bot A, Smith CJ, Laziuk K and Saleh M: B‑cell lymphoma‑associated hemophagocytic lymphohistiocytosis: A case report. Oncol Lett 24: 246, 2022.
APA
Ojo, A.S., Asemota, J., Ojukwu, S., Rajeh, A., Bot, A., Smith, C.J. ... Saleh, M. (2022). B‑cell lymphoma‑associated hemophagocytic lymphohistiocytosis: A case report. Oncology Letters, 24, 246. https://doi.org/10.3892/ol.2022.13365
MLA
Ojo, A. S., Asemota, J., Ojukwu, S., Rajeh, A., Bot, A., Smith, C. J., Laziuk, K., Saleh, M."B‑cell lymphoma‑associated hemophagocytic lymphohistiocytosis: A case report". Oncology Letters 24.2 (2022): 246.
Chicago
Ojo, A. S., Asemota, J., Ojukwu, S., Rajeh, A., Bot, A., Smith, C. J., Laziuk, K., Saleh, M."B‑cell lymphoma‑associated hemophagocytic lymphohistiocytosis: A case report". Oncology Letters 24, no. 2 (2022): 246. https://doi.org/10.3892/ol.2022.13365
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