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Article Open Access

Comparative analysis of transient receptor potential channel 5 opposite strand‑induced gene expression patterns and protein‑protein interactions in triple‑negative breast cancer

  • Authors:
    • Jinghui Peng
    • Shengbin Pei
    • Yangyang Cui
    • Yiqin Xia
    • Yue Huang
    • Xiaowei Wu
    • Mingjie Zheng
    • Miaomiao Weng
    • Xu Han
    • Hongtao Fu
    • Lili Yang
    • Wenbin Zhou
    • Ziyi Fu
    • Shui Wang
    • Hui Xie
  • View Affiliations / Copyright

    Affiliations: Department of Breast Surgery, The First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China, Breast Disease Laboratory, Women and Children Central Laboratory, The First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China
    Copyright: © Peng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 259
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    Published online on: June 14, 2022
       https://doi.org/10.3892/ol.2022.13379
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Abstract

In patients with triple‑negative breast cancer (TNBC), high tumour mutation burden and aberrant oncogene expression profiles are some of the causes of poor prognosis. Therefore, it is necessary to identify aberrantly expressed oncogenes, since they have the potential to serve as therapeutic targets. Transient receptor potential channel 5 opposite strand (TRPC5OS) has been previously shown to function as a novel tumour inducer. However, the underlying mechanism of TRPC5OS function in TNBC remain to be elucidated. Therefore, in the present study TRPC5OS expression was first measured in tissue samples of patients with TNBC and a panel of breast cancer cell lines (ZR‑75‑1, MDA‑MB‑453, SK‑BR‑3, JIMT‑1, BT474 and HCC1937) by using qRT‑PCR and Western blotting. Subsequently, the possible effects of TRPC5OS on MDA‑MB‑231 cells proliferation were determined using Cell Counting Kit‑8 and 5‑Ethynyl‑2'‑deoxyuridine assays after Lentiviral transfection of MDA‑MB‑231. In addition, potential interaction partners of TRPC5OS were explored using liquid chromatography‑mass spectrometry (LC‑MS)/MS. Gene expression patterns following TRPC5OS overexpression were also detected in MDA‑MB‑231 cells by using High‑throughput sequencing. Gene Ontology (GO) and Kyoto Encyclopaedia of Genes and Genomes (KEGG) analysis were then used to systematically verify the potential interactions among the TRPC5OS‑regulated genes. The potential relationship between TRPC5OS‑interacting proteins and gene expression patterns were studied using Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) analysis. TRPC5OS expression was found to be significantly higher in TNBC tumour tissues and breast cancer cell lines compared with luminal tumour tissues and ZR‑75‑1. In addition, the overexpression of TRPC5OS significantly increased cell proliferation. High‑throughput sequencing results revealed that 5,256 genes exhibited differential expression following TRPC5OS overexpression, including 3,269 upregulated genes and 1,987 downregulated genes. GO analysis results indicated that the functions of these differentially expressed genes were enriched in the categories of ‘cell division’ and ‘cell proliferation’ regulation. KEGG analysis showed that the TRPC5OS‑regulated genes were associated with processes of ‘homologous recombination’ and ‘TNF signalling pathways’. Subsequently, 17 TRPC5OS‑interacting proteins were found using LC‑MS/MS and STRING analysis. The most important protein among interacting proteins was ENO1 which was associated with glycolysis and regulated proliferation of cancer. In summary, data from the present study suggest that TRPC5OS overexpression can increase TNBC cell proliferation and ENO1 may be a potential target protein mediated by TRPC5OS. Therefore, TRPC5OS may serve as a novel therapeutic target for TNBC.
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1 

DeSantis CE, Ma J, Gaudet MM, Newman LA, Miller KD, Sauer AG, Jemal A and Siegel RL: Breast cancer statistics, 2019. CA Cancer J Clin. 69:438–451. 2019. View Article : Google Scholar : PubMed/NCBI

2 

Bauer KR, Brown M, Cress RD, Parise CA and Caggiano V: Descriptive analysis of estrogen receptor (ER)-negative, progesterone receptor (PR)-negative, and HER2-negative invasive breast cancer, the so-called triple-negative phenotype: A population-based study from the California cancer registry. Cancer. 109:1721–1728. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Kaplan HG, Malmgren JA and Atwood M: T1N0 triple negative breast cancer: Risk of recurrence and adjuvant chemotherapy. Breast J. 15:454–460. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Mersin H, Yildirim E, Berberoglu U and Gülben K: The prognostic importance of triple negative breast carcinoma. Breast. 17:341–346. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Tan AR and Swain SM: Therapeutic strategies for triple-negative breast cancer. Cancer J. 14:343–351. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Dent R, Trudeau M, Pritchard KI, Hanna WM, Kahn HK, Sawka CA, Lickley LA, Rawlinson E, Sun P and Narod SA: Triple-negative breast cancer: Clinical features and patterns of recurrence. Clin Cancer Res. 13:4429–4434. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Cheang MC, Voduc D, Bajdik C, Leung S, McKinney S, Chia SK, Perou CM and Nielsen TO: Basal-like breast cancer defined by five biomarkers has superior prognostic value than triple-negative phenotype. Clin Cancer Res. 14:1368–1376. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Foulkes WD, Smith IE and Reis-Filho JS: Triple-negative breast cancer. N Engl J Med. 363:1938–1948. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Venkatachalam K and Montell C: TRP channels. Annu Rev Biochem. 76:387–417. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Ma X, Chen Z, Hua D, He D, Wang L, Zhang P, Wang J, Cai Y, Gao C, Zhang X, et al: Essential role for TrpC5-containing extracellular vesicles in breast cancer with chemotherapeutic resistance. Proc Natl Acad Sci USA. 111:6389–6394. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Zhang P, Liu X, Li H, Chen Z, Yao X, Jin J and Ma X: TRPC5-induced autophagy promotes drug resistance in breast carcinoma via CaMKKβ/AMPKα/mTOR pathway. Sci Rep. 7:31582017. View Article : Google Scholar : PubMed/NCBI

12 

Dong Y, Pan Q, Jiang L, Chen Z, Zhang F, Liu Y, Xing H, Shi M, Li J, Li XY, et al: Tumor endothelial expression of P-glycoprotein upon microvesicular transfer of TrpC5 derived from adriamycin-resistant breast cancer cells. Biochem Biophys Res Commun. 446:85–90. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Ma X, Cai Y, He D, Zou C, Zhang P, Lo CY, Xu Z, Chan FL, Yu S, Chen Y, et al: Transient receptor potential channel TRPC5 is essential for P-glycoprotein induction in drug-resistant cancer cells. Proc Natl Acad Sci USA. 109:16282–16287. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Fagerberg L, Hallström BM, Oksvold P, Kampf C, Djureinovic D, Odeberg J, Habuka M, Tahmasebpoor S, Danielsson A, Edlund K, et al: Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics. Mol Cell Proteomics. 13:397–406. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Wichman L, Somasundaram S, Breindel C, Valerio DM, McCarrey JR, Hodges CA and Khalil AM: Dynamic expression of long noncoding RNAs reveals their potential roles in spermatogenesis and fertility. Biol Reprod. 97:313–323. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Lu CW, Zhou DD, Xie T, Hao JL, Pant OP, Lu CB and Liu XF: HOXA11 antisense long noncoding RNA (HOXA11-AS): A promising lncRNA in human cancers. Cancer Med. 7:3792–3799. 2018. View Article : Google Scholar : PubMed/NCBI

17 

Jiang M, Qiu N, Xia H, Liang H, Li H and Ao X: Long noncoding RNA FOXD2AS1/miR1505p/PFN2 axis regulates breast cancer malignancy and tumorigenesis. Int J Oncol. 54:1043–1052. 2019.PubMed/NCBI

18 

Breast Cancer Association Consortium, . Mavaddat N, Dorling L, Carvalho S, Allen J, González-Neira N, Keeman R, Bolla MK, Dennis J, Wang Q, et al: Pathology of tumors associated with pathogenic germline variants in 9 breast cancer susceptibility genes. JAMA Oncol. 8:e2167442022. View Article : Google Scholar : PubMed/NCBI

19 

Schmittgen TD and Livak KJ: Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc. 3:1101–1108. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Hitosugi T, Zhou L, Elf S, Fan J, Kang HB, Seo JH, Shan C, Dai Q, Zhang L, Xie J, et al: Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. Cancer Cell. 22:585–600. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Arito M, Nagai K, Ooka S, Sato T, Takakuwa Y, Kurokawa MS, Sase T, Okamoto K, Suematsu N, Kato T, et al: Altered acetylation of proteins in patients with rheumatoid arthritis revealed by acetyl-proteomics. Clin Exp Rheumatol. 33:877–886. 2015.PubMed/NCBI

22 

Yuan L, Mishra R, Patel H, Abdulsalam S, Greis KD, Kadekaro AL, Merino EJ and Garrett JT: Utilization of reactive oxygen species targeted therapy to prolong the efficacy of BRAF inhibitors in melanoma. J Cancer. 9:4665–4676. 2018. View Article : Google Scholar : PubMed/NCBI

23 

Prasad S, Gupta SC and Tyagi AK: Reactive oxygen species (ROS) and cancer: Role of antioxidative nutraceuticals. Cancer Lett. 387:95–105. 2017. View Article : Google Scholar : PubMed/NCBI

24 

McDonald ES, Clark AS, Tchou J, Zhang P and Freedman GM: Clinical diagnosis and management of breast cancer. J Nucl Med. 57 (Suppl 1):9S–16S. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Yin L, Duan JJ, Bian XW and Yu SC: Triple-negative breast cancer molecular subtyping and treatment progress. Breast Cancer Res. 22:612020. View Article : Google Scholar : PubMed/NCBI

26 

Abdelmalek CM, Hu Z, Kronenberger T, Küblbeck J, Kinnen FJM, Hesse SS, Malik A, Kudolo M, Niess R, Gehringer M, et al: Gefitinib-tamoxifen hybrid ligands as potent agents against triple-negative breast cancer. J Med Chem. 65:4616–4632. 2022. View Article : Google Scholar : PubMed/NCBI

27 

Paskins Z, Bromley K, Lewis M, Hughes G, Hughes E, Hennings S, Cherrington A, Hall A, Holden MA, Stevenson K, et al: Clinical effectiveness of one ultrasound guided intra-articular corticosteroid and local anaesthetic injection in addition to advice and education for hip osteoarthritis (HIT trial): Single blind, parallel group, three arm, randomised controlled trial. BMJ. 377:e0684462022. View Article : Google Scholar : PubMed/NCBI

28 

Chen P, Ning X, Li W, Pan Y, Wang L, Li H, Fan X, Zhang J, Luo T, Wu Y, et al: Fabrication of Tbeta4-exosome-releasing artificial stem cells for myocardial infarction therapy by improving coronary collateralization. Bioact Mater. 14:416–429. 2022. View Article : Google Scholar : PubMed/NCBI

29 

Schneider BP, Winer EP, Foulkes WD, Garber J, Perou CM, Richardson A, Sledge GW and Carey LA: Triple-negative breast cancer: Risk factors to potential targets. Clin Cancer Res. 14:8010–8018. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Yang P, Li J, Peng C, Tan Y, Chen R, Peng W, Gu Q, Zhou J, Wang L, Tang J, et al: TCONS_00012883 promotes proliferation and metastasis via DDX3/YY1/MMP1/PI3K-AKT axis in colorectal cancer. Clin Transl Med. 10:e2112020. View Article : Google Scholar : PubMed/NCBI

31 

Yu J, Wang F, Zhang J, Li J, Chen X and Han G: LINC00667/miR-449b-5p/YY1 axis promotes cell proliferation and migration in colorectal cancer. Cancer Cell Int. 20:3222020. View Article : Google Scholar : PubMed/NCBI

32 

Mohamed TMA, Ang YS, Radzinsky E, Zhou P, Huang Y, Elfenbein A, Foley A, Magnitsky S and Srivastava D: Regulation of cell cycle to stimulate adult cardiomyocyte proliferation and cardiac regeneration. Cell. 173:104–116.e12. 2018. View Article : Google Scholar : PubMed/NCBI

33 

Pike MC, Spicer DV, Dahmoush L and Press MF: Estrogens, progestogens, normal breast cell proliferation, and breast cancer risk. Epidemiol Rev. 15:17–35. 1993. View Article : Google Scholar : PubMed/NCBI

34 

Matson JP and Cook JG: Cell cycle proliferation decisions: The impact of single cell analyses. FEBS J. 284:362–375. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Shostak A: Circadian clock, cell division, and cancer: From molecules to organism. Int J Mol Sci. 18:8732017. View Article : Google Scholar : PubMed/NCBI

36 

Massague J: G1 cell-cycle control and cancer. Nature. 432:298–306. 2004. View Article : Google Scholar : PubMed/NCBI

37 

Bartek J and Lukas J: Pathways governing G1/S transition and their response to DNA damage. FEBS Lett. 490:117–122. 2001. View Article : Google Scholar : PubMed/NCBI

38 

Lupski JR: Genomic disorders: Structural features of the genome can lead to DNA rearrangements and human disease traits. Trends Genet. 14:417–422. 1998. View Article : Google Scholar : PubMed/NCBI

39 

Mizuno K, Miyabe I, Schalbetter SA, Carr AM and Murray JM: Recombination-restarted replication makes inverted chromosome fusions at inverted repeats. Nature. 493:246–249. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Nowosad A and Besson A: Lysosomes at the crossroads of cell metabolism, cell cycle, and stemness. Int J Mol Sci. 23:22902022. View Article : Google Scholar : PubMed/NCBI

41 

Umeda S, Kanda M, Shimizu D, Nakamura S, Sawaki K, Inokawa Y, Hattori N, Hayashi M, Tanaka C, Nakayama G and Kodera Y: Lysosomal-associated membrane protein family member 5 promotes the metastatic potential of gastric cancer cells. Gastric Cancer. 25:558–572. 2022. View Article : Google Scholar : PubMed/NCBI

42 

Finicle BT, Jayashankar V and Edinger AL: Nutrient scavenging in cancer. Nat Rev Cancer. 18:619–633. 2018. View Article : Google Scholar : PubMed/NCBI

43 

Kang HJ, Jung SK, Kim SJ and Chung SJ: Structure of human alpha-enolase (hENO1), a multifunctional glycolytic enzyme. Acta Crystallogr D Biol Crystallogr. 64:651–657. 2008. View Article : Google Scholar : PubMed/NCBI

44 

Cappello P, Principe M, Bulfamante S and Novelli F: Alpha-enolase (ENO1), a potential target in novel immunotherapies. Front Biosci (Landmark Ed). 22:944–959. 2017. View Article : Google Scholar : PubMed/NCBI

45 

Principe M, Borgoni S, Cascione M, Chattaragada MS, Ferri-Borgogno S, Capello M, Bulfamante S, Chapelle J, Modugno FD, Defilippi P, et al: Alpha-enolase (ENO1) controls alpha v/beta 3 integrin expression and regulates pancreatic cancer adhesion, invasion, and metastasis. J Hematol Oncol. 10:162017. View Article : Google Scholar : PubMed/NCBI

46 

Ji M, Wang Z, Chen J, Gu L, Chen M, Ding Y and Liu T: Up-regulated ENO1 promotes the bladder cancer cell growth and proliferation via regulating beta-catenin. Biosci Rep. 39:BSR201905032019. View Article : Google Scholar : PubMed/NCBI

47 

Zhang J, Li H, Miao L and Ding J: Silencing of ENO1 inhibits the proliferation, migration and invasion of human breast cancer cells. J BUON. 25:696–701. 2020.PubMed/NCBI

48 

Song Y, Luo Q, Long H, Hu Z, Que T, Zhang X, Li Z, Wang G, Yi L, Liu Z, et al: Alpha-enolase as a potential cancer prognostic marker promotes cell growth, migration, and invasion in glioma. Mol Cancer. 13:652014. View Article : Google Scholar : PubMed/NCBI

49 

Min Y, Kim MJ, Lee S, Chun E and Lee KY: Inhibition of TRAF6 ubiquitin-ligase activity by PRDX1 leads to inhibition of NFKB activation and autophagy activation. Autophagy. 14:1347–1358. 2018. View Article : Google Scholar : PubMed/NCBI

50 

Coumans JV, Gau D, Poljak A, Wasinger V, Roy P and Moens PD: Profilin-1 overexpression in MDA-MB-231 breast cancer cells is associated with alterations in proteomics biomarkers of cell proliferation, survival, and motility as revealed by global proteomics analyses. OMICS. 18:778–791. 2014. View Article : Google Scholar : PubMed/NCBI

51 

Biterge-Sut B: Alterations in eukaryotic elongation factor complex proteins (EEF1s) in cancer and their implications in epigenetic regulation. Life Sci. 238:1169772019. View Article : Google Scholar : PubMed/NCBI

52 

Palacios G, Shaw TI, Li Y, Singh RK, Valentine M, Sandlund JT, Lim MS, Mullighan CG and Leventaki V: Novel ALK fusion in anaplastic large cell lymphoma involving EEF1G, a subunit of the eukaryotic elongation factor-1 complex. Leukemia. 31:743–747. 2017. View Article : Google Scholar : PubMed/NCBI

53 

Bengsch F, Tu Z, Tang HY, Zhu H, Speicher DW and Zhang R: Comprehensive analysis of the ubiquitinome during oncogene–induced senescence in human fibroblasts. Cell Cycle. 14:1540–1547. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Peng J, Pei S, Cui Y, Xia Y, Huang Y, Wu X, Zheng M, Weng M, Han X, Fu H, Fu H, et al: Comparative analysis of transient receptor potential channel 5 opposite strand‑induced gene expression patterns and protein‑protein interactions in triple‑negative breast cancer. Oncol Lett 24: 259, 2022.
APA
Peng, J., Pei, S., Cui, Y., Xia, Y., Huang, Y., Wu, X. ... Xie, H. (2022). Comparative analysis of transient receptor potential channel 5 opposite strand‑induced gene expression patterns and protein‑protein interactions in triple‑negative breast cancer. Oncology Letters, 24, 259. https://doi.org/10.3892/ol.2022.13379
MLA
Peng, J., Pei, S., Cui, Y., Xia, Y., Huang, Y., Wu, X., Zheng, M., Weng, M., Han, X., Fu, H., Yang, L., Zhou, W., Fu, Z., Wang, S., Xie, H."Comparative analysis of transient receptor potential channel 5 opposite strand‑induced gene expression patterns and protein‑protein interactions in triple‑negative breast cancer". Oncology Letters 24.2 (2022): 259.
Chicago
Peng, J., Pei, S., Cui, Y., Xia, Y., Huang, Y., Wu, X., Zheng, M., Weng, M., Han, X., Fu, H., Yang, L., Zhou, W., Fu, Z., Wang, S., Xie, H."Comparative analysis of transient receptor potential channel 5 opposite strand‑induced gene expression patterns and protein‑protein interactions in triple‑negative breast cancer". Oncology Letters 24, no. 2 (2022): 259. https://doi.org/10.3892/ol.2022.13379
Copy and paste a formatted citation
x
Spandidos Publications style
Peng J, Pei S, Cui Y, Xia Y, Huang Y, Wu X, Zheng M, Weng M, Han X, Fu H, Fu H, et al: Comparative analysis of transient receptor potential channel 5 opposite strand‑induced gene expression patterns and protein‑protein interactions in triple‑negative breast cancer. Oncol Lett 24: 259, 2022.
APA
Peng, J., Pei, S., Cui, Y., Xia, Y., Huang, Y., Wu, X. ... Xie, H. (2022). Comparative analysis of transient receptor potential channel 5 opposite strand‑induced gene expression patterns and protein‑protein interactions in triple‑negative breast cancer. Oncology Letters, 24, 259. https://doi.org/10.3892/ol.2022.13379
MLA
Peng, J., Pei, S., Cui, Y., Xia, Y., Huang, Y., Wu, X., Zheng, M., Weng, M., Han, X., Fu, H., Yang, L., Zhou, W., Fu, Z., Wang, S., Xie, H."Comparative analysis of transient receptor potential channel 5 opposite strand‑induced gene expression patterns and protein‑protein interactions in triple‑negative breast cancer". Oncology Letters 24.2 (2022): 259.
Chicago
Peng, J., Pei, S., Cui, Y., Xia, Y., Huang, Y., Wu, X., Zheng, M., Weng, M., Han, X., Fu, H., Yang, L., Zhou, W., Fu, Z., Wang, S., Xie, H."Comparative analysis of transient receptor potential channel 5 opposite strand‑induced gene expression patterns and protein‑protein interactions in triple‑negative breast cancer". Oncology Letters 24, no. 2 (2022): 259. https://doi.org/10.3892/ol.2022.13379
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